Model Criticism

En este capítulo se describió la síntesis de películas de Ch entrecruzadas con dos agentes distintos. Estos dos agentes entrecruzantes difieren entre sí en las interacciones que mantienen con la matriz del polisacárido. Gen entrecruza formando uniones químicas covalentes mientras que la PVP forma interacciones del tipo puente hidrógeno con Ch. Las películas preparadas fueron evaluadas como potenciales dispositivos de liberación de fármacos utilizando una droga modelo, determinando además los efectos y contribuciones brindadas por el entrecruzamiento físico y químico sobre propiedades tales como el hinchamiento en agua, propiedades mecánicas y térmicas. De acuerdo con los resultados obtenidos, las mejores propiedades se obtuvieron con las películas Ch-Gen 0,10% y Ch-Gen 0,10%- PVP debido a que la liberación del fármaco fue mayor al 80% en un plazo de 7 h, lo que representa un período de dosificación óptimo. Además, estas películas mostraron una mejora en sus propiedades térmicas y mecánicas en relación al material de partida (Ch). De acuerdo a las propiedades generales que han sido optimizadas en esta parte del trabajo, sumadas a las propiedades inherentes del material base como lo son la bioadhesividad y la biocompatibilidad, hacen de las películas de Ch entrecruzadas con Gen y PVP buenos candidatos para potenciales aplicaciones en sistemas de liberación controlada de fármacos en sistemas bucales (Aldana et al., 2012).

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Capítulo V

Co-polímeros de injerto con