Each of the data sets is considered internally consistent as evidenced by the small MARD values. There were insufficient
21.7. Naproxen solubility data in alcohols
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
163G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
(2) Methanol; CH4O;[67-56-1]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2
a x1
b
0.9914 0.00857
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) Purity not given, HPLC grade, Merck Chemical Company, Germany, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2.5% (relative error).
Components: Original Measurements:
(2) Methanol; CH4O;[67-56-1]
Variables: Prepared by:
Temperature W. E. Acree, Jr.
Experimental Values
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Equilibrium jacketed glass vessel, thermostated circulating water bath, electromagnetic stirrer, analytical balance, laser monitoring system.
Experimental solubilities were determined by a synthetic method. Preweighed amounts of solute and solvent and were placed in an equilibrium vessel, which was connected to a circulating constant-temperature water bath. The solution was stirred and small amounts of solute were incrementally added until no further solid dissolved. The dissolution of the solid was determined using laser monitoring. The total amount of solute dissolved was recorded. Experimental measurement was repeated three times.
Source and Purity of Chemicals:
(1) Purity not given, Pharmaceutical Purity grade, Zhejian Chejiu Pharmaceutical Plant, China, dried in vacuo at 323 K for 24 h and stored in a desiccator before use.
(2) 99.8+%, Analytical Reagent grade, Tianjin Chemical Reagent Company, China, no purification information was given in the paper.
Estimated Error: J. Barra, J. Pharm. Pharamcol. 50, 975 (1998).
(2) Methanol; CH4O;[67-56-1]
Variables: Prepared by:
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
cExperimental value was reported in the paper as ln x1.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an ultraviolet/visible spectrophotometer.
Excess solute and solvent were placed in flasks and allowed to equilibrate with shaking for several days at constant temperature. After equilibrium was attained, aliquots of saturated solutions were removed, filtered through 0.2μm pore size membranes, and diluted with 96% ethanol (v/v). Concentrations were determined by spectrophotometric measurements at 233 nm. The reported solubility represents the average of at least three independent determinations.
The density of the saturated solution was determined in order to convert the measured molar solubilities in units of mol dm3to mole fractions.
Source and Purity of Chemicals:
(1) Purity not given, USPA, France, no purification details were provided.
(2) Purity not given, Spectroscopic or Analytical Reagent grade, chemical source not specified, no purification details were provided.
Estimated Error:
163G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) 99.6%, chemical source not specified, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2.5% (relative error).
Components: Original Measurements: F. Martínez, Vitae, Rev. Fac.
Quim. Farm. 15, 113 (2008).
(2) Ethanol; C2H6O;[64-17-5]
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Mechanical stirrer, constant-temperature bath, and an UV/visible spectrophotometer.
Excess solute and solvent were placed in glass bottles, mechanically stirred for 1 h, and then saturated in a constant-temperature bath for 72 h at 313.15 K. The samples were allowed to equilibrate in a constant temperature at 298.15 K for an additional 24 h to allow the precipitation of the excess dissolved drug. An aliquot of the saturated solution was then removed, filtered, and diluted quantitatively with alcohol for spectroscopic analysis. The reported value represents the average of at least three experimental determinations. The densities of the saturated solutions were measured in order to convert the measured concentrations in mol dm3to mole fraction solubilities.
Source and Purity of Chemicals:
(1) Purity not given, USP, no purification details were provided.
(2) Purity not given, Analytical Reagent grade, Merck Chemical Company, Germany, no purification details were provided.
Estimated Error:
Temperature W. E. Acree, Jr.
Experimental Values
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Equilibrium jacketed glass vessel, thermostated circulating water bath, electromagnetic stirrer, analytical balance, laser monitoring system.
Experimental solubilities were determined by a synthetic method. Preweighed amounts of solute and solvent and were placed in an equilibrium vessel, which was connected to a circulating constant-temperature water bath. The solution was stirred and small amounts of solute were incrementally added until no further solid dissolved. The dissolution of the solid was determined using laser monitoring. The total amount of solute dissolved was recorded. Experimental measurement was repeated three times.
Source and Purity of Chemicals:
(1) Purity not given, Pharmaceutical Purity grade, Zhejian Chejiu Pharmaceutical Plant, China, dried in vacuo at 323 K for 24 h and stored in a desiccator before use.
(2) 99.8+%, Analytical Reagent grade, Tianjin Chemical Reagent Company, China, no purification information was given in the paper.
Estimated Error:
164P. Bustamante, M. A. Peña, and J. Barra, J. Pharm. Pharamcol. 50, 975 (1998).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
cExperimental value was reported in the paper as ln x1.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an ultraviolet/visible spectrophotometer.
Excess solute and solvent were placed in flasks and allowed to equilibrate with shaking for several days at constant temperature. After equilibrium was attained, aliquots of saturated solutions were removed, filtered through 0.2μm pore size membranes, and diluted with 96% ethanol (v/v). Concentrations were determined by spectrophotometric measurements at 233 nm. The reported solubility represents the average of at least three independent determinations.
The density of the saturated solution was determined in order to convert the measured molar solubilities in units of mol dm3to mole fractions.
Source and Purity of Chemicals:
(1) Purity not given, USPA, France, no purification details were provided.
(2) Purity not given, Spectroscopic or Analytical Reagent grade, chemical source not specified, no purification details were provided.
Estimated Error:
163G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) Purity not given, HPLC grade, Aldrich Chemical Company, Germany, no purification details were provided.
Estimated Error:
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, anhydrous, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, anhydrous, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
Temperature:0.1 K.
x1:1.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
168F.-Y. Yan, L. Chen, D.-Q. Liu, L.-F. SiMa, M.-J. Chen, H. Shi, and J.-X. Zhu, J. Chem. Eng. Data 54, 1117 (2009).
(2) 2-Propanol; C3H8O;[67-63-0]
Variables: Prepared by:
Temperature W. E. Acree, Jr.
Experimental Values
T/K x2a
x1b
278.15 0.9948 0.005232
283.60 0.9934 0.006644
288.35 0.9920 0.008030
293.75 0.9902 0.009750
298.50 0.9882 0.011810
303.25 0.9857 0.014270
308.65 0.9823 0.017690
313.40 0.9788 0.021180
318.80 0.9741 0.025920
320.15 0.9728 0.027240
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Equilibrium jacketed glass vessel, thermostated circulating water bath, electromagnetic stirrer, analytical balance, laser monitoring system.
Experimental solubilities were determined by a synthetic method. Preweighed amounts of solute and solvent and were placed in an equilibrium vessel, which was connected to a circulating constant-temperature water bath. The solution was stirred and small amounts of solute were incrementally added until no further solid dissolved. The dissolution of the solid was determined using laser monitoring. The total amount of solute dissolved was recorded. Experimental measurement was repeated three times.
Source and Purity of Chemicals:
(1) Purity not given, Pharmaceutical Purity grade, Zhejian Chejiu Pharmaceutical Plant, China, dried in vacuo at 323 K for 24 h and stored in a desiccator before use.
(2) 99.8+%, Analytical Reagent grade, Tianjin Chemical Reagent Company, China, no purification information was given in the paper.
Estimated Error:
Temperature:0.05 K.
x1:0.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
164G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
(2) 1-Butanol; C4H10O;[71-36-3]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2a
x1b
0.9861 0.0139
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) Purity not given, Analytical Reagent grade, Merck Chemical Company, Germany, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 1-Butanol; C4H10O;[71-36-3]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2a
x1b
0.9858 0.01416
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99.8+%, HPLC grade, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, anhydrous, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 2-Methyl-1-propanol; C4H10O;
[78-83-1]
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, anhydrous, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
163G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) Purity not given, Analytical Reagent grade, Aldrich Chemical Company, Germany, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 1-Pentanol; C5H12O;[71-41-0]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2
a x1
b
0.9844 0.01561
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/
visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
Temperature:0.1 K.
x1:1.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
164P. Bustamante, M. A. Peña, and J. Barra, J. Pharm. Pharamcol. 50, 975 (1998).
(2) 1-Pentanol; C5H12O;[71-41-0]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2a x1b,c
0.9683 0.03174
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
cExperimental value was reported in the paper as ln x1.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an ultraviolet/visible spectrophotometer.
Excess solute and solvent were placed in flasks and allowed to equilibrate with shaking for several days at constant temperature. After equilibrium was attained, aliquots of saturated solutions were removed, filtered through 0.2μm pore size membranes, and diluted with 96% ethanol (v/v). Concentrations were determined by spectrophotometric measurements at 233 nm. The reported solubility represents the average of at least three independent determinations.
The density of the saturated solution was determined in order to convert the measured molar solubilities in units of mol dm3to mole fractions.
Source and Purity of Chemicals:
(1) Purity not given, USPA, France, no purification details were provided.
(2) Purity not given, Spectroscopic or Analytical Reagent grade, chemical source not specified, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 2-Pentanol; C5H12O;[6032-29-7]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2a
x1b
0.9850 0.01504
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99+%, Acros Organics, USA, stored over molecular sieves and distilled shortly before use.
Estimated Error:
Temperature:0.1 K.
x1:1.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 3-Methyl-1-butanol; C5H12O;
[123-51-3]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2
a x1
b
0.9880 0.01204
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/
visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to equilibrate for several days at constant temperature. Attainment of equilibrium was verified by several repetitive measurements and by approaching equilibrium from supersaturation. Aliquots of saturated solutions were transferred through a coarse filter into tared volumetric flasks, weighed, and diluted with methanol. Concentrations were determined by
spectrophotometric measurements at 320 nm.
Source and Purity of Chemicals:
(1) 99%, TCI America, Portland, Oregon, USA, was used as received.
(2) 99%, anhydrous, Aldrich Chemical Company, Milwaukee, Wisconsin, USA, stored over molecular sieves before use.
Estimated Error:
Temperature:0.1 K.
x1:1.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
163G. L. Perlovich, S. V. Kurkov, A. N. Kinchin, and A. Bauer-Brandl, Eur. J. Pharm. Biopharm.
57, 411 (2004).
(2) 1-Hexanol; C6H14O;[111-27-3]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2
a x1
b
0.9834 0.0166
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath and an UV/visible spectrophotometer.
Very few experimental details were provided. Excess solute and solvent were allowed to equilibrate at constant temperature. Solubility of the dissolved solute was determined by spectrophotometric measurements.
Source and Purity of Chemicals:
(1) Purity not given, Sigma Chemical Company, St. Louis, Missouri, USA, no purification details were provided.
(2) Purity not given, Analytical Reagent grade, Aldrich Chemical Company, Germany, no purification details were provided.
Estimated Error:
Temperature:0.1 K.
x1:2.5% (relative error).
Components: Original Measurements:
(1) (S)-6-Methoxy- α-methyl-2-naphthaleneacetic acid (Naproxen);
C14H14O3;[22204-53-1]
165C. R. Daniels, A. K. Charlton, R. W. Wold, E. Pustejovsky, A. N.
Furman, A. C. Bilbrey, J. N. Love, J. A. Garza, W. E. Acree, Jr., and M. H. Abraham, Phys. Chem. Liq.
42, 481 (2004).
(2) 1-Hexanol; C6H14O;[111-27-3]
Variables: Prepared by:
T/K ¼ 298.15 W. E. Acree, Jr.
Experimental Values
x2a
x1b
0.9834 0.01663
ax2: mole fraction of component 2 in the saturated solution.
bx1: mole fraction solubility of the solute.
Auxiliary Information Method/Apparatus/Procedure:
Constant-temperature bath, calorimetric thermometer, and an ultraviolet/ visible spectrophotometer.
Excess solute and solvent were placed in amber glass bottles and allowed to
Excess solute and solvent were placed in amber glass bottles and allowed to