1 Introduction
1.5 Outcome
The increasing attention received by the area of DCC methodologies enabled their development, making them one powerful tool to access biologically or industrially relevant compounds. The α-arylation of carbonyls is an appealing synthetic method, given the possibility to further derivatise the carbonyl moiety, and is already
R Br O O + 521 5.0 mol% NaOtBu 2.5 equiv. R THF, 80°C, 6 h R O O R O Ar Ph NH4Cl EtOH /H2O N R R Ar then Ar–Br, 18 h N 546 67% N 547 66% N 548 69% N 549 68% MeN OMe F3C 518 544 545 Et O R' 419 521 [Pd(DtBPF)Cl2] Fe tBu2 P P tBu2 PdCl Cl N+ O O OMe MeO Cl- 552 Berberine N+ O O Cl- 551 Pseudocoptisine N+ OMe OMe OMe MeO Cl- 550 Palmatine O O N+ OMe OMe OMe MeO Cl- 552 Dehydrocordaline Me N+ O O Cl- 553 Unnatural analogue F
years, and its development would give the synthetic community an easy, modular access to important pharmacophores and molecular materials.
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