P (1986) Two calcium currents in a smooth muscle cell line Am Physiol 250, H699-H703.

Friel, D. D. & Tsien, R. W. (1992). A caffeine- and ryanodine-sensitive store in bullfrog sympathetic neurones modulates effects of Ca^^ on /. Physiol

(Lond.) 450, 217-247.

Fry, C. H., Miller, D. J., Harding, D.P. & Harrison, S. M. (1989). The contribution of mitochondrial calcium ion exchange to relaxation of tension in cardiac muscle. M ol Cell Biochem. 89, 127-133.

Ganitkevich, V. Y. A. & Isenberg, G. (1992). Caffeine-induced release and reuptake of Ca^^ by Ca^^ stores in myocytes from urinary bladder. J. Physiol (Lond.) (In Press)

Garfield, R. B. & Somlyo, A. P. (1985). Structure of smooth muscle. In: Calcium and Contractility, Smooth Muscle, ed. Grover, A. K. & Daniel E. E. pp. 1- 36. Clifton: Humana Press.

Godfraind, T. & Kaba, A. (1972). The role of calcium in the action of drugs on vascular smooth muscle. Arch. Intern. Pharmacodyn. 196, 35

Goldman, W. F., Wier, W. G. & Blaustein: M. P. (1989). Effects of activation on distribution of Ca^^ in single arterial smooth muscle cells. Circ. Res. 64, 1019-1029.

Good, N. E., Winget, G. D., Connolly, T. N., Izawa, S. & Singh, R. M. (1966). Hydrogen ion buffers for biological research. Biochemistry 5, 467-477.

Grover, A. K., Kwan, C. Y. & Daniel, E. E. (1981). Na-Ca exchange in rat myometrium membrane vesicles highly enriched in plasma membranes. Am. J. Physiol 240, C175-C182.

Grover, A. K., Kwan, C. Y., Rangachari, P. K. & Daniel, E. E. (1983). Na-Ca exchange in smooth muscle plasma membrane-enriched fraction. Am. J. Physiol 244, C158-C165.

Grynkiewicz, G., Poenie, M. & Tsien, R. Y. (1985). A new generation of Ca^^ indicators with greatly improved fluorescence properties. J. Biol Chem. 260,

3440-3450.

Guan, Y. Y., Kwan, C. Y. & Daniel E. E. (1990). Evidence against the role of ai-adrenoceptor reserve in buffering the inhibitory effect of nifedipine on the contractility of canine vascular smooth muscle. Can, J. Physiol Pharmacol 6 8, 1346-1350.

Hai, C. M. & Murphy, R. A. (1989). Ca^% crossbridge phosphorylation, and contraction. Annu. Rev. Physiol 51, 285-298.

Hakii, H., Fujiki, H., Suganuma, M., Nakayasu, M., Tahira, T., Sugimura, T., Scheuer, P. J. & Christensen, S. B. (1986). Thapsigargin, a histamine secretagogue, is a non-12-o-tetradecanoylphorbol-13-acetate (TPA) type tumor promotor in two stage mouse skin carcinogenesis. J. Cancer. Res. Clin. Oncol 111, 177-181.

Harder, D. R., Kauser, K., Roman, R. J. & Lombard, J. H. (1989). Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium. J. Hypertens. 7, S11-S15.

Harrison, S. M. & Bers, D. M. (1987). The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca- chelators BAPTA and dibromo-BAPTA. Bichim. Biophys. Acta 925, 133-143. Hashimoto, T., Hirata, M., Itoh, T., Kanmura, Y. & Kuriyama, H. (1986). Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery. J. Physiol (Lond.) 370, 605-618. Hirst, G. D. S. & Edwards, F. R. (1989). Sympathetic neuroeffector transmission

in arteries and arterioles. Physiol Rev. 69, 546-604.

lino, M. (1987). Calcium dependent inosotol trisphosphate-induced calcium release in the guinea-pig taenia caeci. Biochem. Biophys. Res. Com. 142, 47- 52.

Ito, K , Takakura, S., Sato, K & Sutko, J. L. (1986). Ryanodine inhibits the release of calcium from intracellular stores in guinea-pig aortic smooth muscle. Circ. Res. 58, 730-734.

Itoh, T., Kajiwara, M., Kitamura, K. & Kuriyama, H. (1982). Role of the stored calcium on the mechanical response evoked in smooth muscle cells of porcine

coronary artery. J. Physiol (Lond.) 322, 107-125.

Itoh, T., Kuriyama, H. & Suzuki, H. (1981). Excitation-contraction coupling in smooth muscle cells of the guinea-pig mesenteric artery. J. Physiol (Lond.) 321, 513-525.

Jackson, T. R., Patterson, S. I., Thastrup, O. & Hanley, M. R. (1988). A novel tumour promoter, thapsigargin, transiently increases cytoplasm free without generation of inositol phosphates in N G l 15-40IL neuronal ceUs. Biochem. J. 253, 81-86.

Jim, K F., Reese, J. B. & Matthews, W. D. (1988). Role of calcium in phorbol- ester-induced contractions of the canine saphenous vein. J. Cardiovasc. Pharmacol II, 24-28.

Kanaide, H., Kobayashi, S., Nishimura, J., Hasegawa, M., Shogakiuchi, Y., Matsumoto, T. & Nakamura, M. (1988). Quin2 microfluorometry and effects of verapamil and diltiazem on calcium release from rat aorta smooth muscle cells in primary culture. Circ. Res. 63, 16-26.

Kanmura, Y., Missiaen, L., Raeymaekers, L. & Casteels, R. (1988). Ryanodine reduces the amount of calcium in intracellular stores of smooth-muscle cells of rabbit ear artery. Pflügers Arch. 413, 153-159.

Kann, K.E. & Stull, J.T. (1989). Regulation of smooth muscle contractile elements by second messengers. Annu. Rev. Physiol 51, 299-313.

Karaki, H., Ahn, H. Y. & Urakawa, N. (1987). Caffeine-induced contraction in vascular smooth muscle. Arch. Int. Pharmacodyn. 285, 60-71.

Kattenburg, M. D. & Daniel, E. E. (1984). Effects of an endogenous cyclic- ATP-dependent protein kinase catalytic subunit on Ca-uptake by plasma membrane vesicles from rat mesenteric artery. Blood Vessels 21, 257-266. Kerrick, W. G. L. & Hoar, P. E. (1981). Inhibition of smooth muscle tension by

cyclic AMP-dependent protein kinase Nature 292, 253-255.

Kobayashi, S., Somlyo, A. V. & Somlyo, A. P. (1988). Heparin inhibits the inositol 1,4,5-trisphosphate-dependent, but not the independent, calcium release induced by guanine nucleotide in vascular smooth artery. Biochem. Biophys. Res. Com. 153, 625-631.

Kowarski, D., Shuman, H., Somlyo, A. P. & Somlyo, A. V. (1985). Calcium release from central sarcoplasmic reticulum in rabbit main pulmonary artery smooth muscle. J. Physiol (Lond.) 366, 153-175.

Kwan, C. W., Takemura, H., Obie, J. F., Thastrup, O. & Putney, Jr, J. W. (1990). Effects of MeCh, thapsigargin, and La^^ on plasmalemmal and intracellular Ca^^ transport in lacrimal acinar cells. Am. J. Physiol 258, C1006- C1015.

Lai, F. A., Anderson, K., Roussseau, E., Liu, Q. Y. & Meissner, G. (1988). Evidence for Ca^^ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum. Biochem. Biophys. Res. Com. 151, 441-449. Lanini, L., Bachs, O. & Carafoli, E. (1992). The calcium pump of the liver

nuclear membrane is identical to that of endoplasmic reticulum. J. Biol Chem. 267, 11548-11552.

Lattanzio, Jr, F. A. (1990). The effects of pH and temperature on fluorescent calcium indicators as determined with chelex-100 and EDTA buffer systems. Biochem. Biophys. Res. Com. 171, 102-108.

Leijten, P. A. A. & van Breemen, C. (1984). The effects of the noradrenaline- sensitive calcium store in rabbit aorta. J. Physiol (Lond.) 357, 327-339. Leijten, P. A. A. & van Breemen, C. (1986). The relationship between

noradrenaline-induced contraction and ^^Ca efflux stimulation in rabbit mesenteric artery. Br. J. Pharmacol 89, 739-747.

Liu, C. & Hermann, T. E. (1978). Characterization of ionomycin as a calcium ionophore. J. Biol Chem. 253, 5892-5894.

Loirand, G., Pacaud, P., Baron, A. & Mironneau, C. (1991). Large conductance calcium-activated non-selective cation channel in smooth muscle cells isolated from rat portal vein. J. Physiol (Lond.) 437, 461-475.

Low, A. M., Gaspar, V., Kwan C. Y., Darby, P. J., Bourreau, J. P. & Daniel, E. E. (1991). Thapsigargin inhibits repletion of phenylephrine-sensitive intracellular Ca^^ pool in vascular smooth muscles. J. Pharmacol Exp. Ther. 258, 1105-1113.

internal Ca^* stores in canine mesenteric artery with different refilling mechanisms. Am. J. Physiol 262, H31-H37.

Luff, S. E., McLachlan, E. M. & Hirst, G. D. S. (1987). An ultrastructural analysis of the sympathetic neuromuscular junctions on arterioles of the submucosa of the guinea-pig ileum. J. Comp. Neurol 257, 578-594.

MacLennan, D. & Wong, P. T.S. (1971).Isolation of calcium sequestering protein from sarcoplasmic reticulum. Proc. Natl Acad. Scl USA 6 8, 1231-1235. Mahoney, M. G., Randall, C. J., Linderman, J. J., Gross, D. J. & Slakey, L. L.

(1992). Independent pathways regulate the cytoplasmic [Ca^^] initial transient and subsequent oscillations in individual cultured arterial smooth muscle cells responding to extracellular ATP. M ol Biol Cell 3, 493-505.

McCormack, J. G. & Denton, R. M. (1989). The role in the regulation of mitochondrial metabohsm and energy production in rat heart. M ol Cell. Biochem. 89, 121-125.

McGuffee, L. J., Little, S. A., Mercure, J. V., Skipper, B. J. & E. S. Wheeler- Clark. (1990). Effects of temperature and buffer composition on calcium sequestration by sarcoplasmic reticulum and plasma membrane of rabbit renal artery. Anat. record. 228, 288-296.

Meehan, A. G. & Kreulen, D. L. (1991). A capsaicin-sensitive inhibitory reflex from the colon to mesenteric arteries in guinea-pig. J. Physiol (Lond.) 448,

153-159.

Melzer, W., Schneider, M. F., Simon, B. J. & Szucs, G. (1986). Intramembrane charge movement and calcium release in frog skeletal muscle. J. Physiol (Lond.) 373, 481-511.

Mikkelsen, E. O., Thastrup, O. & Christensen, S. B. (1988). Effects of thapsigargin in isolated rat thoracic aorta. Pharmacol Toxicol 62, 7-11. Miller, D. J. & Smith, G. L. (1984). EGTA purity and the buffering of calcium

ions in physiological solutions. Am. J. Physiol 246, C160-C166.

Miller, V. M. (1991). Interactions between neural and endothelial mechanisms in control of vascular tone. NIPS 6, 60-63.