flow after birth
Prenatally, umbilical venous blood enters the porta hepa-tis; about 50 % is distributed to the left and right lobes of
30. Lipp JA , Rudolph AM . Sympathetic nerve development in the rat and guinea-pig heart. Biol Neonate 1972 ; 21 : 76 – 82 . 31. Friedman WF , Pool PE , Jacobowitz D et al. Sympathetic innervation of the developing rabbit heart. Biochemical and histochemical comparisons of fetal, neonatal, and adult myocardium. Circ Res 1968 ; 23 : 25 – 32 .
32. Lebowitz EA , Novick JS , Rudolph AM . Development of myocardial sympathetic innervation in the fetal lamb.
Pediatr Res 1972 ; 6 : 887 – 93 .
33. Birk E , Tyndall LC , Rudolph AM , Roberts JM . Effects of thyroid hormone on myocardial adrenergic beta-receptor responsiveness and function during late gestation. Pediatr Res 1992 ; 31 : 468 – 73 .
34. Jansen AH , Chernick V . Respiratory response to cyanide in fetal sheep after peripheral chemodenervation. J Appl Physiol 1974 ; 36 : 1 – 5 .
35. Dawes GS . Foetal and Neonatal Physiology. Chicago, IL : YearBook , 1968 .
36. Itskovitz J , Rudolph AM . Cardiorespiratory response to cyanide of chemoreceptors in fetal lambs. Am J Physiol 1987 ; 252: H916 – 22 .
37. Bartelds B , van Bel F , Teitel DF , Rudolph AM . Carotid, not aortic, chemoreceptors mediate the fetal cardiovascular response to acute hypoxemia in lambs. Pediatr Res 1993 ; 34 : 51 – 5 .
38. Cowley AW Jr, Liard JF , Guyton AC . Role of the baroreflex in daily control of arterial blood pressure and other vari-ables in dogs. Circ Res 1973 ; 32 : 564 – 76 .
39. Itskovitz J , LaGamma EF , Rudolph AM . Baroreflex control of the circulation in chronically instrumented fetal lambs.
Circ Res 1983 ; 52 : 589 – 96 .
40. Teitel DF , Iwamoto HS , Rudolph AM . Effects of birth-related events on central blood flow patterns. Pediatr Res 1987 ; 22 : 557 – 66 .
41. Teitel DF , Iwamoto HS , Rudolph AM . Changes in the pulmonary circulation during birth-related events. Pediatr Res 1990 ; 27 : 372 – 8 .
42. Leffler CW , Hessler JR , Green RS . The onset of breathing at birth stimulates pulmonary prostacyclin synthesis. Pediatr Res 1984 ; 18 : 938 – 42 .
43. Mital S , Konduri GG . Vascular potassium channels mediate oxygen-induced pulmonary vasodilation in fetal lambs.
Biol Neonate 2000 ; 77 : 58 – 68 .
44. Moore P , Velvis H , Fineman JR et al. EDRF inhibition attenuates the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. J Appl Physiol 1992 ; 73 : 2151 – 7 .
45. Sime F , Banchero N , Penaloza D et al. Pulmonary hyperten-sion in children born and living at high altitudes. Am J Cardiol 1963 ; 11 : 143 – 9 .
46. Heymann MA , Rudolph AM . Effects of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Circ Res 1976 ; 38 : 418 – 22 .
47. Levin DL , Hyman AI , Heymann MA , Rudolph AM . Fetal hypertension and the development of increased pulmonary vascular smooth muscle: a possible mechanism for persis-tent pulmonary hypertension of the newborn infant. J Pedi-atr 1978 ; 92 : 265 – 9 . in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 1967 ; 21 : 163 – 8 .
13. Rudolph AM , Heymann MA . Circulatory changes during growth in the fetal lamb. Circ Res 1970 ; 26 : 289 – 99 . 14. Sutton MG , Plappert T , Doubilet P . Relationship between
placental blood flow and combined ventricular output with gestational age in normal human fetus. Cardiovasc Res 1991 ; 25 : 603 – 8 .
15. Meijboom EJ , Horowitz S , Valdes-Cruz LM et al. A Doppler echocardiographic method for calculating volume flow across the tricuspid valve: correlative laboratory and clinical studies. Circulation 1985 ; 71 : 551 – 6 .
16. Kiserud T , Rasmussen S , Skulstad S . Blood flow and the degree of shunting through the ductus venosus in the human fetus. Am J Obstet Gynecol 2000 ; 182 : 147 – 53 . 17. Kohl T , Silverman NH . Evaluation of umbilical venous
blood flow by Doppler color flow mapping and conven-tional ultrasonographic methods. J Ultrasound Med 1996 ; 15 : 465 – 73 .
18. Rasanen J , Wood DC , Debbs RH et al. Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study. Circulation 1998 ; 97 : 257 – 62 .
19. Lewis AB , Heymann MA , Rudolph AM . Gestational changes in pulmonary vascular responses in fetal lambs in utero.
Circ Res 1976 ; 39 : 536 – 41 .
20. Rudolph AM , Heymann MA . Cardiac output in the fetal lamb: the effects of spontaneous and induced changes of heart rate on right and left ventricular output. Am J Obstet Gynecol 1976 ; 124 : 183 – 92 .
21. Romero T , Covell J , Friedman WF . A comparison of pres-sure – volume relations of the fetal, newborn and adult heart.
Am J Physiol 1972 ; 222 : 1285 – 90 .
22. Klopfenstein HS , Rudolph AM . Postnatal changes in the circulation and response to volume loading in the sheep.
Circ Res 1978 ; 42 : 839 – 45 . as determinants of RV stroke volume in the sheep fetus.
Am J Physiol 1983 ; 244: H656 – 63 .
26. Thornburg KL , Morton MJ . Filling and arterial pressures as determinants of left ventricular stroke volume in fetal lambs.
Am J Physiol 1986 ; 251: H961 – 8 .
27. Hawkins J , Van Hare GF , Schmidt KG , Rudolph AM . Effects of increasing afterload on left ventricular output in fetal lambs. Circ Res 1989 ; 65 : 127 – 34 .
arteriosus and umbilical artery to oxygen. Pediatr Res 1972 ; 6 : 693 – 700 .
49. McMurphy DM , Heymann MA , Rudolph AM , Melmon KL . Developmental changes in constriction of the ductus arteriosus: responses to oxygen and vasoactive substances in the isolated ductus arteriosus of the fetal lamb. Pediatr Res 1972 ; 6 : 231 – 8 .
50. Clyman RI , Mauray F , Heymann MA . Ductus arteriosus:
developmental response to oxygen and indomethacin.
Prostaglandins 1978 ; 15 : 993 – 8 .
51. Keller RL , Tacy TA , Fields S et al. Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns. Pediatr Res 2005 ; 58 : 1216 – 21 .
52. Kajino H , Goldbarg S , Roman C et al. Vasa vasorum hypo-perfusion is responsible for medial hypoxia and anatomic remodeling in the newborn lamb ductus arteriosus. Pediatr Res 2002 ; 51 : 228 – 35 .
53. van Bel F , Roman C , Iwamoto HS , Rudolph AM . Sym-pathoadrenal, metabolic, and regional blood flow responses to cold in fetal sheep. Pediatr Res 1993 ; 34 : 47 – 50 .
54. Rudolph AM , Roman C , Gournay VA . Perinatal myocardial DNA and protein changes in the lamb: effect of cortisol in the fetus. Pediatr Res 1999 ; 46 : 141 – 6 .
55. Breall JA , Rudolph AM , Heymann MA . Role of thyroid hormone in postnatal circulatory and metabolic adjust-ments. J Clin Invest 1984 ; 73 : 1418 – 24 .
56. Birk E , Tyndall MR , Erickson LC et al. Effects of thyroid hormone on myocardial adrenergic β -receptor responsive-ness and function during late gestation. Pediatr Res 1992 ; 31 : 468 – 73 .
57. Smolich JJ , Walker AM , Campbell GR , Adamson TM . Left and right ventricular morphometry in fetal, neonatal, and adult sheep. Am J Physiol 1989 ; 257: H1 – 9 .
58. Townsend SF , Rudolph CD , Rudolph AM . Changes in ovine hepatic circulation and oxygen consumption at birth.
Pediatr Res 1989 ; 25 : 300 – 4 .