4. Se logró demostrar la importancia y eficiencia en el uso de ortoésteres 6a-d con respecto a los ácidos carboxílicos 8a-d en su reacción de ciclocondensación con las o-fenilendiaminas 5.
5. Dentro de los compuestos sometidos a los respectivos estudios de actividad antifúngica, se destacan los bencimidazoles 1ga, 1gc, 1ha, 1ja, 1jb, 1bc, 1bd y 1fb, los cuales principalmente mostraron alta actividad frente a la inhibición de cepas de hongos C. neoformans.
6. Con los resultados de actividad biológica se pudo resaltar que no siempre la presencia de halógenos (sobre todo átomos de flúor) en moléculas potencialmente activas, resulta en un aumento de actividad por parte de los sistemas estudiados.
7. La comparación entre los resultados de actividad antifúngica (IC50) permitió concluir que los N-
bencilbencimidazoles sustituidos con cadenas carbonadas más largas en la posición 2, disminuía la actividad. De otro lado, en los N-metilbencimidazoles un aumento de cadena carbonada en la posición 2 favorecía la inhibición, lo que conlleva a determinar que la importancia de la cadena depende del sustituyente de la otra posición.
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1.6.
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