Statistical analysis

All experiments were performed at least in triplicate and representative results are shown. All data are shown as the mean ± standard error. Student’s t-tests were used to evaluate statistical significances between different treatment groups.

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Chapter 4: Constructing the pan-cancer ceRNA network across multiple tumors

4.1 Introduction

Through my analysis of four distinct tumor-specific ceRNA networks, I identified more than 160,000 interactions that are common to all four tumor contexts, including of glioblastoma, the carcinoma of breast, prostate, and ovary. Genome-wide statistical analysis and targeted experimental assays confirmed these interactions in a dozen additional cellular contexts, both tumor and non-tumor related, thus further supporting their predicted pan-cancer nature.