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STATISTICAL INFERENCE IN THE SCIENCES AND SOCIAL SCIENCES

Natural scientists attempt, not always successfully, to control experimentally for all of the other pos- sible sorts of variation other than the relation being studied. By contrast, econometricians are seldom so fortunate. Occasionally, experimental economic studies are done, but such projects are expensive. One such study was the multimillion-dollar health insurance experiment conducted by the RAND Corporation in the late 1970s and early 1980s, funded by the federal government, and we discuss parts of that study in several later sections of the book. (There are excellent reviews by Manning and collaborators, 1987, and Newhouse and collaborators, 1993.) Even with the careful planning that went into the experimental design, this study could not avoid some major analytical issues.

Other fields have similar problems. A 1988 report from the Panel of the Institute of Mathematical Statistics referred to analytical problems in chemistry:

The data are frequently complex with a large number of dimensions, may sometimes have a time element, and can be further complicated because of missing values. In some instances, standard multivariate or time-series methods may suffice for analysis, but, more commonly, novel developments are required, for example, to handle the problem of multivariate calibration (Olkin and Sacks, 1988, p. II-1).

Econometricians must most often use natural experiments and must seek ways to account for the other variations. Because many policies, such as the provision of public health services or the regu- lation of the prescription drug industry, depend on accurate measurement of economic phenomena, it is essential that the measurements be accomplished carefully and scientifically.

ba5.05 bm2.23 babm 5.05  2.23  2.82 0 African American, ba 0 No 1 Yes 0 No Male, bm 1 Yes

FIGURE 3-4 Interpreting the Effects of Dummy Variables

In Table 3-1 (b), coefficient ba= -5.05,

and coefficient bm= +2.23. We see that

African American women (“northeast box”) smoke 5.05 fewer cigarettes than white women. White men smoke 2.23 more cigarettes than white women. Finally, African American men smoke 2.82= (-5.05 + 2.23) fewer cigarettes per day than white women.

CONCLUSIONS

This chapter has provided a “taste” of the statistical methods necessary to address questions that occur in health economics and to clarify the analyses where statistical material is presented later in the text. To understand the text, it is important to be able to formulate questions in terms of hy- potheses, read statistical test results to determine if the result is significant, understand statistical significance, and interpret reported regression results. The emphasis on problems to watch for in statistical analysis is not meant to generate undue skepticism over the statistical data to be report- ed. On the contrary, the discussion is meant to help distinguish the better studies where confidence can best be placed.

Summary

1. Economists usually must collect information from

people doing day-to-day activities and use statistical methods to control for the confounding differences among the people that they are analyzing. The more successful they are in controlling for such differ- ences, the more reliable the analysis will be.

2. Statistical methods suggest formulating econom-

ic assertions as hypotheses, and collecting data to determine whether the hypotheses are correct.

3. Hypotheses that test for equality among two or more

items are called simple hypotheses. Hypotheses that test whether two or more items are greater (or less) than each other are called composite hypotheses.

4. Several steps are necessary to test hypotheses

appropriately. The econometrician must: • state the hypothesis clearly,

• choose a sample that is suitable to the task of testing,

• calculate the appropriate measures of central ten- dency and dispersion, and

• draw the appropriate inferences.

5. Regression analysis allows the econometrician to

fit a straight line through a set of data points. In or- dinary least-squares regression, the sum of the squared deviations of the actual data points from the line is minimized.

6. R2measures the proportion of the total variation explained by the regression model. While it may be desirable to maximize R2, most econometricians are at least as interested in the values of the param- eters that are estimated.

7. Important skills in statistical analysis include:

• understanding statistical significance, • interpreting reported statistical results, and • detecting problems in reported statistical findings.

Discussion Questions

1. List at least three ways in which natural experiments differ from laboratory experiments.

2. What is the difference between a simple hypothesis and a composite hypothesis? Why might economists choose one over another?

3. In considering the difference in smoking between men and women, what is the null hypothesis? What is the alterna- tive hypothesis? Is the alternative hypothesis simple or composite?

4. Suppose that we wish to compare the health status of two groups of people. What variable might we use to measure the status? What variables might we wish to control in order to draw the appropriate inferences?

5. If someone reports that the mean weight for fourth-grade boys is 80 pounds and for fourth-grade girls is 78 pounds,

what must you know to test hypotheses using the difference of means?

6. If we are trying to relate output to labor inputs and capital inputs using regression analysis, would we expect the coef- ficients of the regressions to be positive or negative? Why? 7. What are dummy variables? How are they useful in identi-

fying differences among groups?

8. Suppose that you used regression methods to estimate the demand curve for physician visits and found a positive rela- tionship; that is, you found that the higher the price is, the more visits are demanded. What problem has likely arisen? Explain the problem in words. Why might it make statisti- cal inference difficult?

9. Rich people consume more health care services than poor people. Explain two ways one might test this hypothesis.

Exercises

(For students with access to spreadsheet computer pro- grams.) Consider the following data for a cross section of individuals in the population, in which

Q= Quantity (in 100s) of aspirin purchased in a year P= Average price of aspirin in that year

Y= Annual income A= Age of buyer

Now consider questions 1 to 4:

1. If we divide the population into two groups, up to age 35 and over age 35, which group purchases more aspirin? 2. Divide the population into three groups—up to age 30, over

30 and up to 45, and over 45. Do the purchases vary by age? 3. What is the relationship in a regression analysis between Q

and P? Between Q and Y? Between Q and A?

Observation Q P Y A 1 1 1.5 20 25 2 2 1.5 40 20 3 4 1 12 25 4 2 1 10 30 5 2 1 8 30 6 3 2 30 35 7 3.5 1.5 30 40 8 4 2 20 40 9 7 1 20 45 10 1 3 15 40 11 2 2 18 30 12 3 2 20 32 13 3.5 2 15 36 14 4 2 10 30 15 2 3 25 20 Observation Q P Y A 16 1 4 15 25 17 8 2 15 55 18 9 1 40 50 19 1 4 10 45 20 10 1.5 30 55 21 6 1.5 35 60 22 2 1 30 40 23 3 1 25 40 24 3 2 20 35 25 3 2 15 35 26 4 3 20 35 27 1 4 20 25 28 1 4 25 30 29 2 5 28 30 30 3 1 30 32

4. Calculate the multiple regression that relates Q with P, Y, and A. Which variables are statistically significant? What is the elasticity of Q with respect to P, to Y, and/or to A? 5. From Table 3-1, column b, suppose income is $20,000,

the excise tax on cigarettes is $1, and the person is a 40- year-old white, non-Hispanic male who completed high school (education level = 9). Calculate the elasticities of demand for aspirin with respect to excise tax, income, and age.

6. Consider demand curves for aspirin, estimated for two dif- ferent sets of consumers:

(a) Q= 20 - 5P + 0.2Y (b) Q= 30 - 5P + 0.2Y

If Y= $20 and P = $1, calculate the price and income elas- ticities for group (a) and group (b). Whose elasticities will be higher? Why?

7. Given the regression estimate of the demand equation of

where Y is income, what is the change in demand if price rises by $1, holding income constant? What is the per- centage change in demand if price rises by $1 from an initial price of Px= $200 given Y = 10,000? What is the

effect on demand of a $1 increase in income, holding price constant?

Qx = 1,000 - 3.3Px + 0.001Y

8. Consider the estimate demand equation of

with t values in parentheses, where Pzis the price of an-

other good Z, and Y is income. Is good Z a substitute or a complement? Can we say confidently whether good X is a normal good or an inferior good?

9. Look at Regression (b) in Table 3-1, and consider the fol- lowing questions:

(a) Does cigarette consumption increase as income rises? Are cigarettes a “necessity” or a “luxury”?

(b) For the variable “Educational Level” a high school grad- uate is coded with level 9, and a college graduate is coded with level 12. What is the predicted difference in cigarette consumption between the two levels of education? 10. Table 22-1 shows GDP/capita and total health care spending

per capita for 29 countries (the first two columns of numbers). (a) Calculate the means of both variables.

(b) Calculate a regression relating health care spending to GDP/capita.

(c) Using the method discussed in equation (3.10) calcu- late the income elasticity of health expenditures. (d) What does your answer to part c indicate about the

“share” of GDP/capita going to health? Why? 10.52 12.12 13.52

63Economic Efficiency

Cost-Benefit Analysis: BackgroundCost-Benefit Analysis: Basic PrinciplesValuing Human Life

Cost-Effectiveness Analysis

Cost-Utility Analysis, QALYs, and DALYsQALYs Revisited: Praise and CriticismConclusions

Appendix—Discounting

I

n health economics, policy concerns require that we frequently and systematically evaluate alternatives. Just as rational individuals want to make the best choices given resource constraints, governments, too, face choices constrained by resource availability. For example, legislators and other policymakers must decide whether to spend more on preventive care versus giving more support to acute care facilities, or perhaps to med- ical research. When government regulates, its own expenditures may be relatively small. The economic conse- quences of its regulation can be very large, however, and corresponding care must be taken in evaluating the alternative scenarios. Economists base such decisions on the concept of efficiency. In developing the microeco- nomic tools for this textbook, we explained the “welfare loss” caused by a monopoly restricting quantity of pro- duction by charging too high a price. The nature of this welfare loss is that it describes inefficiency—society has foregone opportunities for mutual gain. Efficiency, however, applies to a broader range of phenomena than just monopoly, and we will begin here by developing the concept more fully.

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