En los resultados obtenidos en el presente estudio, se muestra el efecto que tiene el polimorfismo A293V del gen SCD1 sobre la composición de los ácidos grasos de la leche, de modo que los animales con genotipo AA y AV presentan un mayor contenido de ácido miristoleico (C14:1 cis-9) y una aparente mayor conversión del ácido saturado C14:0 a su forma monoinsaturada, sin embargo no se pudo identificar una influencia significativa del genotipo sobre la insaturación de los ácidos grasos C16:0, C18:0 y C18:1 tras-11. Es necesario realizar más investigaciones en las cuales se estudie la relación del polimorfismo con el contenido de ácidos grasos en diferentes estadíos de la lactancia, adicionalmente sería interesante mirar si en animales con diferentes genotipos bajo dietas suplementadas con ácidos grasos se puede apreciar cambios significativos en los contenidos de ácidos graso insaturados.
3.7 Referencias
Baeza MC, Corva PM, Soria LA, Pavan E, Rincon G, Medrano JF (2013) Genetic variants in a lipid regulatory pathway as potential tools for improving the nutritional quality of grass-fed beef. Animal Genetics 44, 121–129. doi:10.1111/j.1365-2052.2012.02386.x. Barton L, Kott T, Bures D, Rehák D, Zahrádková R, Kottová B (2010) The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls. Meat science 85, 15–20.
doi:10.1016/j.meatsci.2009.11.016.
Carvajal AM, Huircan P, Dezamour JM, Subiabre I, Kerr B, Morales R, Ungerfeld EM (2016a) Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation. Genetics and Molecular Research
15,. doi:10.4238/gmr.15027057.
Carvajal AM, Huircan P, Dezamour JM, Subiabre I, Kerr B, Morales R, Ungerfeld EM (2016b) Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation. Genetics and Molecular Research
15,. doi:10.4238/gmr.15027057.
Chung KY, Lunt DK, Kawachi H, Yano H, Smith SB (2007) Lipogenesis and stearoyl-CoA desaturase gene expression and enzyme activity in adipose tissue of short- and long- fed Angus and Wagyu steers fed corn- or hay-based diets. Journal of animal science
85, 380–7. doi:10.2527/jas.2006-087.
Conte G, Mele M, Chessa S, Castiglioni B, Serra a, Pagnacco G, Secchiari P (2010) Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. Journal of dairy science 93, 753–63. doi:10.3168/jds.2009-2581. Faustini M (2016) A Survey on Mono-, Polyunsaturated Fatty Acids, Desaturase Indices and Atherogenic Index in the Milk Fat of Local Breeds (Cabannina, Varzese and Valdostana) Reared in Northern Italy. Journal of Dairy, Veterinary & Animal Research
Feng S, Salter AM, Parr T, Garnsworthy PC (2007) Extraction and quantitative analysis of stearoyl-coenzyme A desaturase mRNA from dairy cow milk somatic cells. Journal of Dairy Science 90, 4128–4136. doi:10.3168/jds.2006-830.
Glasser F, Schmidely P, Sauvant D, Doreau M (2008) Digestion of fatty acids in ruminants: A meta-analysis of flows and variation factors: 2. C18 fatty acids. Animal 2, 691–704. doi:10.1017/S1751731108002036.
Hanus O, Samkova E, Křížova L, Hasoňova L, Kala R (2018) Role of fatty acids in milk fat and the influence of selected factors on their variability—a review. Molecules 23, 1– 32. doi:10.3390/molecules23071636.
Houaga I, Muigai AWT, Ng’ang’a FM, Ibeagha-Awemu EM, Kyallo M, Youssao IAK, Stomeo F (2018) Milk fatty acid variability and association with polymorphisms in SCD1 and DGAT1 genes in White Fulani and Borgou cattle breeds. Molecular Biology Reports
45, 1849–1862. doi:10.1007/s11033-018-4331-4.
Jensen RG (2002) The composition of bovine milk lipids: January 1995 to December 2000. J. Dairy Sci. 85, 295–350. doi:10.3168/jds.S0022-0302(02)74079-4.
Kelsey JA, Corl BA, Collier RJ, Bauman DE (2003a) The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. Journal of Dairy Science 86, 2588–2597. doi:10.3168/jds.S0022-0302(03)73854-5.
Kelsey J a, Corl B a, Collier RJ, Bauman DE (2003b) The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. Journal of dairy science 86, 2588–2597. doi:10.3168/jds.S0022-0302(03)73854-5.
Kgwatalala PM, Ibeagha-Awemu EM, Mustafa AF, Zhao X (2009a) Influence of stearoyl- coenzyme A desaturase 1 genotype and stage of lactation on fatty acid composition of Canadian Jersey cows. Journal of dairy science 92, 1220–1228. doi:10.3168/jds.2008-1471.
Kgwatalala PM, Ibeagha-Awemu EM, Mustafa AF, Zhao X (2009b) Stearoyl-CoA desaturase 1 genotype and stage of lactation influences milk fatty acid composition of Canadian Holstein cows. Animal Genetics 40, 609–615. doi:10.1111/j.1365- 2052.2009.01887.x.
Mazidi M, Mikhailidis DP, Sattar N, Toth PP, Judd S, Blaha MJ, Hernandez A V., Penson PE, Banach M (2020) Association of types of dietary fats and all-cause and cause- specific mortality: A prospective cohort study and meta-analysis of prospective studies with 1,148,117 participants. Clinical Nutrition 1–10. doi:10.1016/j.clnu.2020.03.028. Mele M, Conte G, Castiglioni B, Chessa S, Macciotta NPP, Serra A, Buccioni A, Pagnacco
G, Secchiari P (2007) Stearoyl-Coenzyme A Desaturase Gene Polymorphism and Milk Fatty Acid Composition in Italian Holsteins. Journal of Dairy Science 90, 4458–4465. doi:10.3168/jds.2006-617.
Mele M, Dal Zotto R, Cassandro M, Conte G, Serra A, Buccioni A, Bittante G, Secchiari P (2009) Genetic parameters for conjugated linoleic acid, selected milk fatty acids, and milk fatty acid unsaturation of Italian Holstein-Friesian cows. Journal of dairy science
92, 392–400. doi:10.3168/jds.2008-1445.
Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Research 16, 1215. doi:10.1093/nar/16.3.1215.
Miyazaki M, Ntambi JM (2003) Role of stearoyl-coenzyme A desaturase in lipid metabolism.
68, 113–121.
Mosley EE, McGuire MA (2007) Methodology for the in vivo measurement of the Δ9- desaturation of myristic, palmitic, and stearic acids in lactating dairy cattle. Lipids 42, 939–945. doi:10.1007/s11745-007-3085-x.
Neofytou MC, Miltiadou D, Sfakianaki E, Constantinou C, Symeou S, Sparaggis D, Hager- Theodorides AL, Tzamaloukas O (2020) The use of ensiled olive cake in the diets of Friesian cows increases beneficial fatty acids in milk and Halloumi cheese and alters the expression of SREBF1 in adipose tissue. Journal of Dairy Science. doi:10.3168/jds.2020-18235.
Parodi PW (1997) Cows ’ Milk Fat Components as Potential Anticarcinogenic Agents. journal of nutrition 127, 1055–1060.
Pereira SL, Leonard AE, Mukerji P (2003) Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes. Prostaglandins Leukotrienes and
Essential Fatty Acids 68, 97–106. doi:10.1016/S0952-3278(02)00259-4.
Rico JE, Moreno B, Pabón ML, Carulla J (2007) Composición de la grasa láctea en la sabana de Bogotá con énfasis en ácido ruménico - CLA cis -9 , trans -11. Revista Colombiana de Ciencias Pecuarias 20, 30–39.
Rooke JA, Flockhart JF, Sparks NH (2010) The potential for increasing the concentrations of micro-nutrients relevant to human nutrition in meat, milk and eggs. Journal of Agricultural Science 148, 603–614. doi:10.1017/S002185961000047X.
Ruspoli Foterguerri EB (2015) Síntesis endógena de ácidos grasos en la glándula mamaria y síndrome de baja grasa en la leche en ovejas. Universidad de León. https://digital.csic.es/bitstream/10261/129073/1/Elena Bichi 2015.pdf.
Schennink a, Heck JML, Bovenhuis H, Visker MHPW, van Valenberg HJF, van Arendonk J a M (2008) Milk fatty acid unsaturation: genetic parameters and effects of stearoyl- CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). Journal of dairy science 91, 2135–43. doi:10.3168/jds.2007-0825.
Shanklin J, Whittle E, Fox BG (1994) Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase. Biochemistry 33, 12787–12794. doi:10.1021/bi00209a009.
Soedamah-Muthu SS, Guo J (2020) “Dairy consumption and cardiometabolic diseases: Evidence from prospective studies.” (Elsevier Inc.) doi:10.1016/b978-0-12-815603- 2.00001-2.
De Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J, Anand SS (2015) Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: Systematic review and meta-analysis of observational studies. BMJ 351,. doi:10.1136/bmj.h3978.
Stefanov I, Vlaeminck B, Fievez V (2010) A novel procedure for routine milk fat extraction based on dichloromethane. Journal of Food Composition and Analysis 23, 852–855. doi:10.1016/j.jfca.2010.03.016.
Ulbricht TLV, Southgate D a. T (1991) Coronary heart disease: seven dietary factors. The Lancet 338, 985–992. doi:10.1016/0140-6736(91)91846-M.
Ungerfeld EM, Urrutia NL, Vásconez-Montúfar C, Morales R (2019) Factors associated with the content of mammary-synthesized fatty acids in milk fat: A meta-analysis. Journal of Dairy Science 102, 4105–4117. doi:10.3168/jds.2018-15157.
Vasilopoulou D, Markey O, Kliem KE, Fagan CC, Grandison AS, Humphries DJ, Todd S, Jackson KG, Givens DI, Lovegrove JA (2020) Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: The randomized, controlled REplacement of. American Journal of Clinical Nutrition 111, 739–748. doi:10.1093/ajcn/nqz344.