Translation to the Clinic 131

Anisotropic FOV and resolution for ZTE SNR enhancement: As mentioned briefly in

132

therefore be sacrificed along the long axis of the bone in favor of higher SNR, and the alias-free FOV can be reduced orthogonal to this axis to reduce scan time. This method has already been developed (143) and implemented on phantoms in our lab, and could easily be incorporated into an in vivo scan protocol.

Scaling of the combined 31P and 1H method to human subjects: The work outlined in

Chapter 5 was performed on clinical scanners, but used a small solenoidal RF coil. Scaling this method to a larger volume coil, sized to fit the human leg, would entail an SNR penalty. This loss of SNR must be quantified, particularly in 31P, and appropriate pulse sequence modifications should be implemented to regain this lost SNR.

Tracking of response of mineral density, matrix density, and DMB to anti- resorptive treatment in post-menopausal osteoporotic women: The ultimate test of this method for paired measurement of bone mineral and matrix densities is its ability to measure a response to treatment of post-menopausal osteoporotic female subjects with standard anti-resorptive therapy. Accuracy and reproducibility should first be assessed in healthy control subjects, and then this method should be applied to a group of post- menopausal osteoporotic women undergoing treatment with bisphosphonates, and a group of matched healthy control subjects, to track the recovery of bone mineral and matrix densities and DMB.

133

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