Underlying toxicity data and statistical methods to construct SSDs

11. REFERENCIAS

1. GREBO. Grupo para el control de la resistencia bacteriana en Bogotá. Boletín informativo. 2015.

2. Conde C, Saavedra C LA. Descripción de tipos de carbapenemasas expresadas en Klebsiella sp. y Pseudomonas aeruginosa en hospitales de tercer nivel de la ciudad de Bogotá, estudio descriptivo. Universidad Nacional de Colombia; 3. Pacheco R, Osorio L, Correa AM, Villegas MV. Prevalencia de bacterias Gram

negativas portadoras del gen blaKPC en hospitales de Colombia. Biomédica [Internet]. 2014 Apr 1;34(Sup1 SE-Artículos originales):81–90. Available from: https://revistabiomedica.org/index.php/biomedica/article/view/1642

4. Villegas MV, Lolans K, Correa A, Kattan JN, Lopez JA, Quinn JP, et al. First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. Antimicrob Agents Chemother [Internet]. 2007/01/29. 2007 Apr;51(4):1553–5. Available from:

https://pubmed.ncbi.nlm.nih.gov/17261621

5. Vanegas JM, Cienfuegos A V, Ocampo AM, López L, del Corral H, Roncancio G, et al. Similar frequencies of Pseudomonas aeruginosa isolates producing KPC and VIM carbapenemases in diverse genetic clones at tertiary-care hospitals in Medellín, Colombia. J Clin Microbiol. 2014 Nov;52(11):3978–86. 6. World Health Organization - WHO. Antimicrobial resistance: global report on

surveillance. 2014. 257 p.

7. Prabaker K, Weinstein RA. Trends in antimicrobial resistance in intensive care units in the United States. Curr Opin Crit Care. 2011 Oct;17(5):472–9.

8. van Duijn PJ, Dautzenberg MJD, Oostdijk EAN. Recent trends in antibiotic resistance in European ICUs. Curr Opin Crit Care. 2011 Dec;17(6):658–65. 9. Rhomberg PR, Jones RN. Summary trends for the Meropenem Yearly

Susceptibility Test Information Collection Program: a 10-year experience in the United States (1999-2008). Diagn Microbiol Infect Dis. 2009 Dec;65(4):414–26. 10. Centers for Disease Control and Prevention. Vital signs: carbapenem-resistant

Enterobacteriaceae. MMWR Morb Mortal Wkly Rep. 2013 Mar;62(9):165–70. 11. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the

United States. [Internet]. 2013. Available from:

https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf

12. Borer A, Saidel-Odes L, Riesenberg K, Eskira S, Peled N, Nativ R, et al. Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol. 2009 Oct;30(10):972–6.

13. Villalobos AP, Díaz MH, Barrero LI, Rivera SM, Henríquez DE, Villegas MV et al. Tendencias de los fenotipos de resistencia bacteriana en los hospitales públicos y privados de alta complejidad de Colombia. Rev Panam Salud Pública. 2011;30 (6):627–33.

14. Maya JJ, Ruiz SJ, Blanco VM, Gotuzzo E, Guzman-Blanco M, Labarca J, et al. Current status of carbapenemases in Latin America. Expert Rev Anti Infect Ther. 2013 Jul;11(7):657–67.

15. Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a

carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 2001 Apr;45(4):1151–61.

16. Ruiz-Garbajosa P, Curiao T, Tato M, Gijón D, Pintado V, Valverde A, et al. Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain. J Antimicrob Chemother. 2013 Nov;68(11):2487–92.

17. Gales AC, Castanheira M, Jones RN, Sader HS. Antimicrobial resistance among Gram-negative bacilli isolated from Latin America: results from SENTRY

Antimicrobial Surveillance Program (Latin America, 2008-2010). Diagn Microbiol Infect Dis. 2012 Aug;73(4):354–60.

18. Mensa J, Gatell J G-SJ et al. Guía de terapéutica antimicrobiana [Internet]. Barcelona: Editorial Antares; 2010. Available from:

https://dialnet.unirioja.es/servlet/articulo?codigo=6336737

19. Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas y Bennett. Enfermedades infecciosas. Síndrome de inmunodeficiencia adquirida [Internet]. Elsevier Health Sciences Spain; 2015. Available from:

https://books.google.com.co/books?id=txJACwAAQBAJ

20. Bush K, Jacoby GA. Updated functional classification of beta-lactamases. Antimicrob Agents Chemother. 2010 Mar;54(3):969–76.

21. Villegas MV, Lolans K, Correa A, Suarez CJ, Lopez JA, Vallejo M, et al. First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother [Internet]. 2006 Aug;50(8):2880–2. Available from:

https://pubmed.ncbi.nlm.nih.gov/16870793

22. Mojica Medina MF. Widespread Dissemination of KPC-2 and 3-Producing Enterobacteriaceae (EB) in Colombia. In: 51 st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago-USA; 2011.

23. Gasink LB, Edelstein PH, Lautenbach E, Synnestvedt M, Fishman NO. Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Infect Control Hosp Epidemiol [Internet]. 2009

Dec;30(12):1180–5. Available from: https://pubmed.ncbi.nlm.nih.gov/19860564 24. Zavascki AP, Barth AL, Gonçalves ALS, Moro ALD, Fernandes JF, Martins AF,

et al. The influence of metallo-beta-lactamase production on mortality in nosocomial Pseudomonas aeruginosa infections. J Antimicrob Chemother. 2006 Aug;58(2):387–92.

25. Crespo MP, Woodford N, Sinclair A, Kaufmann ME, Turton J, Glover J, et al. Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia. J Clin Microbiol. 2004 Nov;42(11):5094–101.

26. Villegas MV, Lolans K, del Rosario Olivera M, Suarez CJ, Correa A, Queenan AM, et al. First detection of metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa isolates from Colombia. Antimicrob Agents Chemother. 2006 Jan;50(1):226–9.

27. Montealegre MC, Correa A, Briceño DF, Rosas NC, De La Cadena E, Ruiz SJ, et al. Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia. Antimicrob Agents Chemother [Internet]. 2011/01/31. 2011 May;55(5):2428–30. Available from:

https://pubmed.ncbi.nlm.nih.gov/21282438

28. Rojas LJ, Mojica MF, Blanco VM, Correa A, Montealegre MC, De La Cadena E, et al. Emergence of Klebsiella pneumoniae Coharboring KPC and VIM

Carbapenemases in Colombia. Antimicrob Agents Chemother [Internet]. 2012/12/10. 2013 Feb;57(2):1101–2. Available from:

https://pubmed.ncbi.nlm.nih.gov/23229478

29. Escobar Pérez JA, Olarte Escobar NM, Castro-Cardozo B, Valderrama Márquez IA, Garzón Aguilar MI, Martinez de la Barrera L, et al. Outbreak of NDM-1- producing Klebsiella pneumoniae in a neonatal unit in Colombia. Antimicrob Agents Chemother. 2013 Apr;57(4):1957–60.

30. Villegas MV, Kattan JN, Correa A, Lolans K, Guzman AM, Woodford N, et al. Dissemination of Acinetobacter baumannii clones with OXA-23 Carbapenemase in Colombian hospitals. Antimicrob Agents Chemother [Internet]. 2007/04/02. 2007 Jun;51(6):2001–4. Available from:

https://pubmed.ncbi.nlm.nih.gov/17403994

identification of OXA-72 carbapenemase from Acinetobacter pittii in Colombia. Antimicrob Agents Chemother [Internet]. 2012/04/16. 2012 Jul;56(7):3996–8. Available from: https://pubmed.ncbi.nlm.nih.gov/22508295

32. Vanegas JM, Higuita LF, Vargas CA, Cienfuegos AV, Rodríguez EA, Roncancio GE, et al. Acinetobacter baumannii resistente a carbapenémicos causante de osteomielitis e infecciones de la piel y los tejidos blandos en hospitales de Medellín, Colombia. Biomédica [Internet]. 2015 Dec 1;35(4 SE-Artículos originales):522–30. Available from:

https://revistabiomedica.org/index.php/biomedica/article/view/2572

33. Instituto Nacional de Salud. Resultados del Programa de Informe de Resultados de la Vigilancia por Laboratorio de Resistencia antimicrobiana en Infecciones Asociadas a la Atención en Salud (IAAS) 2017. 2017;

34. El Zowalaty ME, Al Thani AA, Webster TJ, El Zowalaty AE, Schweizer HP, Nasrallah GK, et al. Pseudomonas aeruginosa: arsenal of resistance

mechanisms, decades of changing resistance profiles, and future antimicrobial therapies. Future Microbiol. 2015;10(10):1683–706.

35. Xiao M, Wang Y, Yang Q-W, Fan X, Brown M, Kong F, et al. Antimicrobial susceptibility of Pseudomonas aeruginosa in China: a review of two multicentre surveillance programmes, and application of revised CLSI susceptibility

breakpoints. Int J Antimicrob Agents [Internet]. 2012;40(5):445–9. Available from: http://www.sciencedirect.com/science/article/pii/S0924857912002798 36. Potron A, Poirel L, Nordmann P. Emerging broad-spectrum resistance in

Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology. Int J Antimicrob Agents. 2015 Jun;45(6):568–85.

37. Walsh TR, Toleman MA, Poirel L, Nordmann P. Metallo-beta-lactamases: the quiet before the storm? Clin Microbiol Rev [Internet]. 2005 Apr;18(2):306–25. Available from: https://pubmed.ncbi.nlm.nih.gov/15831827

38. Marquez-Ortiz RA, Haggerty L, Olarte N, Duarte C, Garza-Ramos U, Silva- Sanchez J, et al. Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance. Genome Biol Evol. 2017 Jun;9(6):1725–41.

39. Sevillano E, Gallego L, García-Lobo JM. First detection of the OXA-40

carbapenemase in P. aeruginosa isolates, located on a plasmid also found in A. baumannii. Pathol Biol (Paris). 2009 Sep;57(6):493–5.

40. Abril D, Marquez-Ortiz RA, Castro-Cardozo B, Moncayo-Ortiz JI, Olarte Escobar NM, Corredor Rozo ZL, et al. Genome plasticity favours double chromosomal Tn4401b-blaKPC-2 transposon insertion in the Pseudomonas aeruginosa ST235 clone. BMC Microbiol [Internet]. 2019;19(1):45. Available from:

https://doi.org/10.1186/s12866-019-1418-6

41. Martinez E, Pérez JE, Buelvas F, Tovar C, Vanegas N, Stokes HW.

Establishment and multi drug resistance evolution of ST235 Pseudomonas aeruginosa strains in the intensive care unit of a Colombian hospital. Res Microbiol. 2014 Dec;165(10):852–6.

42. Pirnay J-P, De Vos D, Cochez C, Bilocq F, Vanderkelen A, Zizi M, et al. Pseudomonas aeruginosa displays an epidemic population structure. Environ Microbiol. 2002 Dec;4(12):898–911.

43. Pirnay J-P, Bilocq F, Pot B, Cornelis P, Zizi M, Van Eldere J, et al.

Pseudomonas aeruginosa population structure revisited. PLoS One. 2009 Nov;4(11):e7740.

44. Mulet X, Cabot G, Ocampo-Sosa AA, Domínguez MA, Zamorano L, Juan C, et al. Biological markers of Pseudomonas aeruginosa epidemic high-risk clones. Antimicrob Agents Chemother. 2013 Nov;57(11):5527–35.

45. Cholley P, Thouverez M, Hocquet D, van der Mee-Marquet N, Talon D, Bertrand X. Most multidrug-resistant Pseudomonas aeruginosa isolates from hospitals in eastern France belong to a few clonal types. J Clin Microbiol [Internet].

2011/05/18. 2011 Jul;49(7):2578–83. Available from: https://pubmed.ncbi.nlm.nih.gov/21593258

46. Peña C, Cabot G, Gómez-Zorrilla S, Zamorano L, Ocampo-Sosa A, Murillas J, et al. Influence of virulence genotype and resistance profile in the mortality of Pseudomonas aeruginosa bloodstream infections. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2015 Feb;60(4):539–48.

47. Miriagou V, Cornaglia G, Edelstein M, Galani I, Giske CG, Gniadkowski M, et al. Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2010 Feb;16(2):112–22.

48. Nordmann P, Poirel L, Dortet L. Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis [Internet]. 2012 Sep;18(9):1503–7. Available from: https://pubmed.ncbi.nlm.nih.gov/22932472

49. Cury AP, Andreazzi D, Maffucci M, Caiaffa-Junior HH, Rossi F. The modified Hodge test is a useful tool for ruling out Klebsiella pneumoniae carbapenemase. Clinics (Sao Paulo) [Internet]. 2012 Dec;67(12):1427–31. Available from:

https://pubmed.ncbi.nlm.nih.gov/23295597

50. Giakkoupi P, Vourli S, Polemis M, Kalapothaki V, Tzouvelekis LS, Vatopoulos AC. Supplementation of growth media with Zn2+ facilitates detection of VIM-2- producing Pseudomonas aeruginosa. Vol. 46, Journal of clinical microbiology. 2008. p. 1568–9.

51. Tsakris A, Kristo I, Poulou A, Themeli-Digalaki K, Ikonomidis A, Petropoulou D, et al. Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J Clin Microbiol. 2009 Feb;47(2):362–7.

52. Pasteran F, Mendez T, Guerriero L, Rapoport M, Corso A. Sensitive screening tests for suspected class A carbapenemase production in species of

Enterobacteriaceae. J Clin Microbiol [Internet]. 2009/04/22. 2009

Jun;47(6):1631–9. Available from: https://pubmed.ncbi.nlm.nih.gov/19386850 53. Giske CG, Gezelius L, Samuelsen Ø, Warner M, Sundsfjord A, Woodford N. A

sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks

supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin. Clin Microbiol Infect [Internet]. 2011;17(4):552–6. Available from:

http://www.sciencedirect.com/science/article/pii/S1198743X14632729

54. Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration. PLOS Med [Internet]. 2007 Oct 16;4(10):e297. Available from: https://doi.org/10.1371/journal.pmed.0040297 55. World Health Organization - WHO. Global priority list of antibiotic-resistant

bacteria to guide research, discovery, and development of new antibiotics. 2017; Available from: https://www.who.int/medicines/publications/global-priority-list- antibiotic-resistant-bacteria/en/

56. Kung VL, Ozer EA, Hauser AR. The accessory genome of Pseudomonas aeruginosa. Microbiol Mol Biol Rev [Internet]. 2010 Dec;74(4):621–41. Available from: https://pubmed.ncbi.nlm.nih.gov/21119020

57. Tato M, Coque TM, Baquero F, Cantón R. Dispersal of carbapenemase blaVIM- 1 gene associated with different Tn402 variants, mercury transposons, and conjugative plasmids in Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010 Jan;54(1):320–7.

58. Juhas M, van der Meer JR, Gaillard M, Harding RM, Hood DW, Crook DW. Genomic islands: tools of bacterial horizontal gene transfer and evolution. FEMS Microbiol Rev [Internet]. 2008/10/29. 2009 Mar;33(2):376–93. Available from: https://pubmed.ncbi.nlm.nih.gov/19178566

L, Méndez JL, González-Valencia G, et al. Genetic and phenotypic

characterization of a Pseudomonas aeruginosa population with high frequency of genomic islands. PLoS One [Internet]. 2012/05/25. 2012;7(5):e37459– e37459. Available from: https://pubmed.ncbi.nlm.nih.gov/22662157

60. Battle SE, Rello J, Hauser AR. Genomic islands of Pseudomonas aeruginosa. FEMS Microbiol Lett [Internet]. 2009 Jan 1;290(1):70–8. Available from: https://doi.org/10.1111/j.1574-6968.2008.01406.x

61. Bennett PM. Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria. Br J Pharmacol. 2008 Mar;153

Suppl(Suppl 1):S347-57.

62. Bonnin RA, Poirel L, Nordmann P, Eikmeyer FG, Wibberg D, Pühler A, et al. Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-β-lactamase gene blaVIM-2 from Pseudomonas aeruginosa. J Antimicrob Chemother. 2013 May;68(5):1060–5.

63. Li H, Toleman MA, Bennett PM, Jones RN, Walsh TR. Complete Sequence of p07-406, a 24,179-base-pair plasmid harboring the blaVIM-7 metallo-beta- lactamase gene in a Pseudomonas aeruginosa isolate from the United States. Antimicrob Agents Chemother. 2008 Sep;52(9):3099–105.

64. Rodríguez-Andrade E, Hernández-Ramírez KC, Díaz-Peréz SP, Díaz-Magaña A, Chávez-Moctezuma MP, Meza-Carmen V, et al. Genes from pUM505 plasmid contribute to Pseudomonas aeruginosa virulence. Antonie Van Leeuwenhoek. 2016 Mar;109(3):389–96.

65. Herschleb J, Ananiev G, Schwartz DC. Pulsed-field gel electrophoresis. Nat Protoc. 2007;2(3):677–84.

66. Abril Riaño DJ. Análisis de las plataformas genéticas de movilización de genes de resistencia en el clon de Pseudomonas aeruginosa ST235 causante de infecciones en Colombia [Internet]. Universidad Nacional de Colombia - Sede Bogotá; 2017 Apr. Available from: http://bdigital.unal.edu.co/57072/

67. Monteiro J, Widen RH, Pignatari ACC, Kubasek C, Silbert S. Rapid detection of carbapenemase genes by multiplex real-time PCR. J Antimicrob Chemother. 2012 Apr;67(4):906–9.

68. Curran B, Jonas D, Grundmann H, Pitt T, Dowson CG. Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa. J Clin Microbiol. 2004 Dec;42(12):5644–9. 69. Li H, Durbin R. Fast and accurate long-read alignment with Burrows-Wheeler

transform. Bioinformatics. 2010 Mar;26(5):589–95.

70. Milne I, Stephen G, Bayer M, Cock PJA, Pritchard L, Cardle L, et al. Using Tablet for visual exploration of second-generation sequencing data. Brief Bioinform. 2013 Mar;14(2):193–202.

71. Krumsiek J, Arnold R, Rattei T. Gepard: a rapid and sensitive tool for creating dotplots on genome scale. Bioinformatics. 2007 Apr;23(8):1026–8.

72. Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics. 2014 Jul;30(14):2068–9.

73. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012 Nov;67(11):2640–4.

74. McArthur AG, Waglechner N, Nizam F, Yan A, Azad MA, Baylay AJ, et al. The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348–57.

75. Gupta SK, Padmanabhan BR, Diene SM, Lopez-Rojas R, Kempf M, Landraud L, et al. ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes. Antimicrob Agents Chemother [Internet]. 2014;58(1):212–20. Available from:

http://europepmc.org/abstract/MED/24145532

faster version of the PHAST phage search tool. Nucleic Acids Res [Internet]. 2016/05/03. 2016 Jul 8;44(W1):W16–21. Available from:

https://pubmed.ncbi.nlm.nih.gov/27141966

77. Langille MGI, Brinkman FSL. IslandViewer: an integrated interface for

computational identification and visualization of genomic islands. Bioinformatics [Internet]. 2009/01/16. 2009 Mar 1;25(5):664–5. Available from:

https://pubmed.ncbi.nlm.nih.gov/19151094

78. Sullivan MJ, Petty NK, Beatson SA. Easyfig: a genome comparison visualizer. Bioinformatics [Internet]. 2011/01/28. 2011 Apr 1;27(7):1009–10. Available from: https://pubmed.ncbi.nlm.nih.gov/21278367

79. Cuzon G, Naas T, Nordmann P. Functional characterization of Tn4401, a Tn3- based transposon involved in blaKPC gene mobilization. Antimicrob Agents Chemother. 2011 Nov;55(11):5370–3.

80. Naas T, Cuzon G, Truong H-V, Nordmann P. Role of ISKpn7 and deletions in blaKPC gene expression. Antimicrob Agents Chemother. 2012 Sep;56(9):4753–9. 81. Cheruvanky A, Stoesser N, Sheppard AE, Crook DW, Hoffman PS, Weddle E, et

al. Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion. Antimicrob Agents Chemother. 2017 Jun;61(6).

82. Hernández-Gómez C, Blanco VM, Motoa G, Correa A, Maya JJ, de la Cadena E, et al. Evolución de la resistencia antimicrobiana de bacilos Gram negativos en unidades de cuidados intensivos en Colombia. Biomédica [Internet]. 2014 Apr 1;34(Sup1 SE-Artículos originales):91–100. Available from:

https://revistabiomedica.org/index.php/biomedica/article/view/1667

83. Pragasam AK, Yesurajan F, Doss C GP, George B, Devanga Ragupathi NK, Walia K, et al. Draft Genome Sequence of Extremely Drug-Resistant

Pseudomonas aeruginosa (ST357) Strain CMC_VB_PA_B22862 Isolated from a Community-Acquired Bloodstream Infection. Genome Announc. 2016 Oct;4(5). 84. Bonnin RA, Bogaerts P, Girlich D, Huang T-D, Dortet L, Glupczynski Y, et al.

Molecular Characterization of OXA-198 Carbapenemase-Producing

Pseudomonas aeruginosa Clinical Isolates. Antimicrob Agents Chemother. 2018 Jun;62(6).

85. Shankar C, Mathur P, Venkatesan M, Pragasam AK, Anandan S, Khurana S, et al. Rapidly disseminating blaOXA-232 carrying Klebsiella pneumoniae belonging to ST231 in India: multiple and varied mobile genetic elements. BMC Microbiol. 2019 Jun;19(1):137.

86. Doi Y. Treatment Options for Carbapenem-resistant Gram- negative Bacterial Infections. Clinical Infectious Diseases. 2019;69(S7): S565–75.