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Type I Interferons Are Essential in Controlling Neurotropic Coronavirus Infection Irrespective of Functional CD8 T Cells

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FIG. 2. CNS expression of IFN-I and IFN-stimulated genes in re-sponse to infection. Brains from uninfected (0) and infected (day 4 and

FIG. 4. Neutrophils dominate cell infiltrates in the CNS of IFNAR�and IFNARPercentages of cell subsets within the infiltrating population identified as neutrophils (B), macrophages (C), CD4 T cells (D), and CD8 T cells (E).Data are the means of three experime

FIG. 5. Enhanced inﬂammatory responses in IFNAR�CBA was used to measure the concentrations of inﬂammatory cyto-kines in brain supernatants of wt and IFNARthe mean concentrations of cytokinesData are derived from two independent experiments (point)

FIG. 6. Impaired IFN-I signaling does not affect expansion and CNS recruitment of virus-speciﬁc CD8 T cells

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