An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans.

Even though cells from HCV clearers did not target regions of higher variability than those from chronics (i.e., comparable numbers of variants per 10-mer region targeted were tested

(A to C) The CTL line isolated from patient P04 was tested for its ability to lyse via perforin-granzyme secretion peptide-pulsed JY cells (APC ⫹ p) (2,500 JY cells/well) (A), JY

cause it is not known whether the IV NA-231 peptide is endog- enously processed and presented by IV-infected cells, an HCV NS3-1073 -specific CTL line expanded from PBMC of pa-

2, the lower virus-specific CTL activity in normal mice was not the result of the presence of suppressing macrophages in vitro, since CTL activity in the nonadherent cells

MHC-specific CD8+ CTL in unstimulated PBMC from H521 at 8 weeks after infection were assayed for cytotoxicity of autologous EK cells infected with a control recombinant vaccinia

(A) Peripheral blood mononuclear cells from a patient with acute viral hepatitis (patient 1) were stimulated with a mixture of overlapping HBcAg peptides and then tested for the

HBV-specific CTL response in patients with acute HBV one of whom (patients A-1) was cur- rently infected and the other (patient A-2) had re- solved the infection 16 mo earlier;

one chronic hepatitis patient had various lengths of deletions spanning from 105 to 183 bp in the middle of the core gene, and all deletions included common nucleotide sequences. All