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Oestrogen inactivation in the colon: analysis of the expression and regulation of 17β-hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer

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Academic year: 2019

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Figure 1Immunolocalization of 17layer (β-HSD2 (A–C) and 17β-HSD4 (D–F) in: (A and D) placenta (positive control) (× 100); (B and E) colon surface epithelial cell× 100); (C and F) colonic mucosa adjacent to a tumour (left) and colonic tumour tissue (right)
Figure 3Effect of steroid hormones on 17(DHT), testosterone (T), progesterone (Prg), and 1,25-dihydroxyvitamin D(1,25Dβ-HSD activity in colonic cancercells
Figure 4Effects of steroid hormones on 17** = significantly different from control cells, β-HSD activity and cell proliferation in SW-620 cells
Figure 6Western blot analysis of 17cells. Changes in the expression of proteins for 17β-HSD2 and 4 expression in SW-620β-HSD2 and 4 wereassessed following treatment with oestradiol (E2), oestrone (E1),progesterone (Prg), or 1,25-dihydroxyvitamin D3 (1,25D3

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