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Ultrastructural and Biophysical Characterization of Hepatitis C Virus Particles Produced in Cell Culture

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Academic year: 2019

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Figure

FIG. 1. Infectious HCV particles purified by sucrose gradient cen-trifugation. (A) Concentrated supernatants isolated from infected cells
FIG. 2. HCV particles are pleomorphic and display E2 and apolipoprotein E on their surface
FIG. 3. Particles treated with 0.2% NP-40 are noninfectious anddisplay a decrease in diameter
FIG. 4. cryoEM showed that purified HCV particles are predominantly spherical and consist of subpopulations with different diameters
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