MCQ's Pharmacy Chapter-1

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1 1 1.

1. The ability of a substance dissolves inThe ability of a substance dissolves in a given solvent system is depends on a given solvent system is depends on (a)

(a) Nature and intensity Nature and intensity of the forcesof the forces present in the solute

present in the solute (b)

(b) Nature and intensity Nature and intensity of the forcesof the forces present in the solvent

present in the solvent (c)

(c) Interactions between solute andInteractions between solute and solvent

solvent (d)

(d) All the aboveAll the above 2.

2. Which of the following substancesWhich of the following substances having poor water solubility

having poor water solubility (a)

(a) Weak electrolytesWeak electrolytes (b)

(b) Non-polar molecules Non-polar molecules (c)

(c) BothBoth (d)

(d) None None 3.

3. The solubility of weak electrolytes &The solubility of weak electrolytes & non-polar substances can be increased non-polar substances can be increased by

by adding adding water water miscible miscible solventsolvents.s. This process is known as

This process is known as (a) Co-solvency (a) Co-solvency (b) Complexation (b) Complexation (c) Both (c) Both (d) None (d) None 4.

4. How co-solvents increase the solubilityHow co-solvents increase the solubility of poorly soluble drugs?

of poorly soluble drugs? (a)

(a) By By reducing reducing the the interfacialinterfacial tension between the predominant tension between the predominant aqueous solution and aqueous solution and hydrophobic solute

phobic solute (b)

(b) By By reducing reducing the the interfacialinterfacial tension between solute and tension between solute and solvent solvent (c) Both (c) Both (d) None (d) None 5.

5. Which of the following co – solventsWhich of the following co – solvents are used to increase the solubility of a are used to increase the solubility of a drug drug (a) Ethanol (a) Ethanol (b) Sorbitol (b) Sorbitol (c) Glycerin (c) Glycerin (d)

(d) All All the the aboveabove 6.

6. Which of the following co – solvent isWhich of the following co – solvent is accepted as a co – solvent in parenteral accepted as a co – solvent in parenteral produ

products, cts, but but its its use use in in oral oral liquids liquids isis limited

limited (a)

(a) Glycerol formalGlycerol formal (b)

(b) GlycerolGlycerol (c)

(c) Dimethyl acetamideDimethyl acetamide (d)

(d) None None 7.

7. Due to which factor, dimethyl aceta-Due to which factor, dimethyl aceta-mide is not been used as a co-solvent mide is not been used as a co-solvent in oral liquids

in oral liquids (a)

(a) Due Due to to objectionable objectionable odorodor (b)

(b) Due Due to to objectionable objectionable tastetaste (c) Both

(c) Both (d) None (d) None 8.

8. Thiomersal is belongs to whichThiomersal is belongs to which category preservative category preservative (a) Acidic (a) Acidic (b) Neutral (b) Neutral (c) Mercurial (c) Mercurial (d)

(d) Quaternary Quaternary ammoniumammonium compounds

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9.

9. Which of the following are widelyWhich of the following are widely used and excellent preservatives

used and excellent preservatives (a) Mercurial

(a) Mercurial (b)

(b) Quaternary Quaternary ammonium ammonium compoundscompounds (c) Both

(c) Both (d) Acidic (d) Acidic 10.

10. Benzalkonium chloride is categorizedBenzalkonium chloride is categorized as

as (a)

(a) Acidic Acidic preservativepreservative (b)

(b) Neutral Neutral preservativepreservative (c)

(c) Mercurial Mercurial preservativepreservative (d)

(d) Quaternary Quaternary ammoniumammonium compounds

compounds 11.

11. At which concentration, phenol act asAt which concentration, phenol act as preserv preservativeative (a) 0.2 (a) 0.2 – – 0.5 0.5 (b) 0.5 (b) 0.5 – – 0.80.8 (c) 0 (c) 0.05 .05 – – 0.1 0.1 (d) (d) NoneNone 12.

12. Which of the following sugar has bitterWhich of the following sugar has bitter taste

taste (a)

(a) Glucose Glucose (b) (b) SucroseSucrose (c)

(c) Saccharine Saccharine (d) (d) NoneNone 13.

13. Which of the following is a syntheticWhich of the following is a synthetic sweetener

sweetener (a)

(a) Glucose Glucose (b) (b) SucroseSucrose (c)

(c) Sorbitol Sorbitol (d) (d) AspartameAspartame 14.

14. To increase the viscosity of To increase the viscosity of liquid, whichliquid, which of the following agents are used

of the following agents are used (a) PVP

(a) PVP (b)

(b) Methyl Methyl CelluloseCellulose (c)

(c) Sodium Sodium Carboxy Carboxy MethylMethyl Cellulose

Cellulose (d)

15. Which of the following agents are usedWhich of the following agents are used as flavoring agents

as flavoring agents (a)

(a) Menthol Menthol (b) (b) ChloroformChloroform (c)

(c) Both Both (d) (d) NoneNone

16.

16. Most widely used flavoring agent inMost widely used flavoring agent in food industry food industry (a) Menthol (a) Menthol (b) Chloroform (b) Chloroform (c)

(c) Mono Mono sodium sodium glutamateglutamate (d) None

(d) None 17.

17. Which of the following flavor is notWhich of the following flavor is not responsible for sour taste

responsible for sour taste (a)

(a) Citrus Citrus flavors flavors (b) Liquorice(b) Liquorice (c)

(c) Raspberry Raspberry (d) (d) Mint Mint spicespice 18.

18. The filling method of a pharmaceuticalThe filling method of a pharmaceutical liquid depends on the following factors liquid depends on the following factors (a)

(a) Viscosity Viscosity of of the the liquidliquid (b)

(b) Surface Surface tension tension of of the the liquidliquid (c) Compatibility with the materials (c) Compatibility with the materials used in the construction of the used in the construction of the filling machine

filling machine (d)

19. Which of the following methods areWhich of the following methods are generally used in liquid filling

generally used in liquid filling (a) Gravimetric

(a) Gravimetric (b) Volumetric (b) Volumetric (c)

(c) Constant Constant level level methodmethod (d)

20. In the formulation of suspensions,In the formulation of suspensions, generally which types of drugs are generally which types of drugs are selected?

selected? (a)

(a) Hydrophilic Hydrophilic (b) (b) HydrophobicHydrophobic (c)

(c) Both Both (d) (d) NoneNone 21.

21. In the formulation, to facilitate theIn the formulation, to facilitate the wetting of insoluble solids, which of wetting of insoluble solids, which of the following agents used

the following agents used (a)

(a) Suspending Suspending agentsagents (b)

(b) Flavoring Flavoring agentsagents (c)

(c) Wetting Wetting agentsagents (d) None

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22.

22. How surfactants will facilitate or aidHow surfactants will facilitate or aid wetting of hydrophobic materials in wetting of hydrophobic materials in liquid

liquid

(a) By decreasing the solid-liquid (a) By decreasing the solid-liquid

interfacial tension interfacial tension (b)

(b) By By increasing increasing the the solid-liquidsolid-liquid interfacial tension interfacial tension (c) Both (c) Both (d) None (d) None 23.

23. Stoke’s equation is expressed asStoke’s equation is expressed as (a) (a) 2 2 1 1 22 2 2rr ((dd – d– d ))gg V V == 9 9ηη (b) (b) 2 2 1 1 22 2 2rr ((dd – d– d ))gg V V == 18 18ηη (c) Both (c) Both (d) None (d) None 24.

24. The stability of suspensions can beThe stability of suspensions can be evaluated by

evaluated by (a)

(a) Sedimentation Sedimentation volumevolume (b)

(b) Degree Degree of of flocculationflocculation (c) Re-dispersibility (c) Re-dispersibility (d) All

(d) All 25.

25. To identify the emulsion type, which ofTo identify the emulsion type, which of the following tests are conducted? the following tests are conducted? (a)

(a) Dilution Dilution testtest (b)

(b) Dye Dye testtest (c)

(c) Conductivity Conductivity testtest (d) All

(d) All

26.

26. The temperature at which the inversionThe temperature at which the inversion occurs depends on emulsifier occurs depends on emulsifier concen-tration is known as

tration is known as (a)

(a) Phage Phage temperaturetemperature (b)

(b) Inversion Inversion temperaturetemperature (c)

(c) Phase Phase inversion inversion temperaturetemperature (d) All

(d) All 27.

27. Which of the following mechanicalWhich of the following mechanical equipment can be used for equipment can be used for emulsifi-cation?

cation?

(a) Homogenizers (a) Homogenizers (b)

(b) Mechanical Mechanical stirrersstirrers (c)

(c) Ultra Ultra sonifierssonifiers (d) All

(d) All 28.

28. Which of the following is not used as aWhich of the following is not used as a emulsifying agent?

emulsifying agent? (a) Surfactant (a) Surfactant (b)

(b) Hydrophilic Hydrophilic colloidscolloids (c) Electrolytes

(c) Electrolytes (d)

(d) Finely Finely divided divided solidssolids 29.

29. HLB system was developed byHLB system was developed by (a)

(a) Griffin Griffin (b) (b) Stock’sStock’s (c)

(c) Dalla Dalla Valle Valle (d) (d) NoneNone 30.

30. Gum Arabic is aGum Arabic is a (a)

(a) Anionic Anionic polysaccharidepolysaccharide (b)

(b) Cationic Cationic polysaccharidepolysaccharide (c)

(c) Neutral Neutral polysaccharidepolysaccharide (d) None

(d) None KEY

KEY 1

1. . ((aa) ) 22. . ((cc) ) 33.. ((aa) ) 44.. ((aa) ) 55. . ((d)d) 6 6. . ((cc) ) 77. . ((cc) ) 88.. ((cc) ) 99.. ((cc) ) 1100. . ((dd)) 11 11. . (a(a) ) 1212. . (c(c) ) 113.3. (d(d) ) 114.4. (d(d) ) 1515. . (c(c)) 16 16. . ((c) c) 117. 7. ((d) d) 1818.. (d) (d) 1919.. ((d) d) 2020. . (b(b)) 21 21. . ((c) c) 222. 2. (a(a) ) 223.3. (b(b) ) 224.4. (d(d) ) 2525. . (d(d)) 26 26. . (c(c) ) 227. 7. (d(d) ) 228.8. (c(c) ) 2929.. ((a) a) 3030. . (c(c))

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1.

1. Which of the following is not aWhich of the following is not a semisolid dosage form

semisolid dosage form (a)

(a) Paste Paste (b) (b) CreamsCreams (c)

(c) Ointments Ointments (d) (d) SuspensionsSuspensions 2.

2. Generally pastes containGenerally pastes contain (a)

(a) High High percentage percentage of of insolubleinsoluble solids

solids (b)

(b) Low Low percentage percentage of of insolubleinsoluble solids solids (c) Both (c) Both (d) None (d) None 3.

3. Most widely used hydrocarbon inMost widely used hydrocarbon in semi-solid dosage forms

semi-solid dosage forms (a)

(a) Petrolatum Petrolatum (b) (b) Mineral Mineral oiloil (c)

4. Which of the following hydrocarbonWhich of the following hydrocarbon waxes are employed in the manufacture waxes are employed in the manufacture of creams and ointments?

of creams and ointments? (a) Paraffin

(a) Paraffin wax wax (b) (b) CeresinCeresin (c)

5. Which of the following is not aWhich of the following is not a vegetable oil

vegetable oil (a)

(a) Peanut Peanut oil oil (b) (b) Almond Almond oiloil (c)

(c) Olive Olive oil oil (d) (d) PetrolatumPetrolatum 6.

6. Which of the following fatty acid used inWhich of the following fatty acid used in water removable creams as emulsifier water removable creams as emulsifier (a) Stea

(a) Stearic ric acid acid (b) Palmitic (b) Palmitic acidacid (c)

7. Combination of a surfactant with oil-Combination of a surfactant with oil-soluble auxiliary emulsifier is known soluble auxiliary emulsifier is known as

as (a)

(a) Simple Simple emulsifier emulsifier systemsystem (b)

(b) Mixed Mixed emulsifier emulsifier systemsystem (c) Both

(c) Both (d) None (d) None

8.

8. Promulgen meansPromulgen means (a)

(a) Anionic Anionic emulsifiers emulsifiers composed composed ofof fatty alcohols & their ethoxylates fatty alcohols & their ethoxylates (b)

(b) Non-ionic Non-ionic emulsifiers emulsifiers com-posedcom-posed of fatty alcohols & their of fatty alcohols & their ethoxylates

ethoxylates (c)

(c) Cationic Cationic emulsifiers emulsifiers composed composed ofof fatty alcohols & their ethoxylates fatty alcohols & their ethoxylates (d)

(d) All the All the aboveabove 9.

9. Promulgen D containsPromulgen D contains (a)

(a) Cetyl Cetyl alcohol alcohol & & Ceteareth-20Ceteareth-20 (b)

(b) Stearyl Stearyl alcohol alcohol & & Ceteareth-20Ceteareth-20 (c) Both

10. Promulgen G containsPromulgen G contains (a)

(a) Cetyl Cetyl alcohol alcohol & & Ceteareth-20Ceteareth-20 (b)

(b) Stearyl Stearyl alcohol alcohol & & Ceteareth-20Ceteareth-20 (c) Both

11. With promulgen D, which type ofWith promulgen D, which type of emulsion generally obtained?

emulsion generally obtained? (a)

(a) Liquid Liquid emulsionemulsion (b)

(b) Thick Thick consistency consistency emulsionemulsion (c) Both

12. With promulgen G, which type ofWith promulgen G, which type of emulsion generally obtained?

emulsion generally obtained? (a)

(a) Liquid Liquid emulsionemulsion (b)

(b) Thick Thick consistency consistency emulsionemulsion (c) Both

13. Which of the following polyols used asWhich of the following polyols used as humectants in creams

humectants in creams (a) Glycerine

(a) Glycerine (b)

(b) Propylene Propylene glycolglycol (c)

(c) Sorbitol Sorbitol 70%70% (d)

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14.

14. The choice of humectants is based onThe choice of humectants is based on (a)

(a) Rate Rate of of moisture moisture exchangeexchange (b)

(b) Viscosity Viscosity and and texture texture ofof preparation preparation (c) Both (c) Both (d) None (d) None 15.

15. Which of the following is moreWhich of the following is more hygroscopic at low concentration? hygroscopic at low concentration? (a)

(a) Sorbitol Sorbitol 70% 70% (b) Glycerine(b) Glycerine (c)

16. Due to which factors, petrolatum isDue to which factors, petrolatum is most widely used as a hydrocarbon most widely used as a hydrocarbon basic in

basic in ointmenointmentsts (a)

(a) Its Its consistencyconsistency (b)

(b) Its Its neutral neutral characteristicscharacteristics (c)

(c) Its abIts ability to ility to spread spread easily on easily on thethe skin

skin (d) All (d) All 17.

17. Water number meansWater number means (a)

(a) Maximum Maximum amount amount of of water water thatthat can be added to 100 g of a base at can be added to 100 g of a base at given temperature

given temperature (b)

(b) Maximum Maximum amount amount of of water water thatthat can be added to 10 g of a base at can be added to 10 g of a base at given temperature

given temperature (c)

(c) Maximum Maximum amount amount of of water water thatthat can be added to 5 g of a base at can be added to 5 g of a base at given temperature

given temperature (d) All

(d) All 18.

18. Lanolin is which type of baseLanolin is which type of base (a)

(a) Hydrocarbon Hydrocarbon basebase (b)

(b) Absorption Absorption basebase (c) Both

19.

19. In the preparation of vanishing creams,In the preparation of vanishing creams, which types of bases are used which types of bases are used generally?

generally? (a)

(a) Absorption Absorption basesbases (b)

(b) Water Water removable removable basesbases (c)

(c) Hydrocarbon Hydrocarbon basesbases (d) None

(d) None 20.

20. In the preparation of cold creams,In the preparation of cold creams, which types of bases are used which types of bases are used generally?

generally? (a)

(a) Absorption Absorption basesbases (b)

(b) Water Water removable removable basesbases (c)

(c) Hydrocarbon Hydrocarbon basesbases (d) None

(d) None 21.

21. Water soluble bases are also known asWater soluble bases are also known as (a)

(a) Greasy Greasy ointment ointment basesbases (b)

(b) Greaseless Greaseless ointment ointment basesbases (c) Both

22. In pastes, the concentration ofIn pastes, the concentration of insoluble powder substances in

insoluble powder substances in (a) 20%-50% (a) 20%-50% (b) 50%-100% (b) 50%-100% (c) 50%-75% (c) 50%-75% (d) None (d) None 23.

23. Jellies are generallyJellies are generally (a)

(a) Water-soluble Water-soluble basesbases (b)

(b) Water-insoluble Water-insoluble basesbases (c) Both

24. As per USP XX, the term “object-As per USP XX, the term “object-ionable” means

ionable” means (a)

(a) An organism An organism can cause can cause disease ordisease or the presence may interrupt the the presence may interrupt the function of the drug or lead to function of the drug or lead to deterioration of the product

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(b)

(b) Pathogens Pathogens if if they they produceproduce disease or infection, in the disease or infection, in the newborn or debilitated persons newborn or debilitated persons (c)

(c) Organisms Organisms or or their their toxins toxins that that areare responsible for human disease or responsible for human disease or infection

infection (d) None (d) None

25.

25. The success or failure of a preservativeThe success or failure of a preservative in protecting a formulation against in protecting a formulation against microbial spoilage depends on

microbial spoilage depends on (a)

(a) Interaction Interaction between between preservativepreservative with surfactant

with surfactant (b)

(b) Interaction Interaction between between preservativepreservative with active substances

with active substances (c)

(c) Sorption Sorption by by packaging packaging materialsmaterials (d)

(d) All All the the aboveabove

KEY KEY 1 1. . ((dd) ) 22. . ((aa) ) 3..3 ((cc) ) 44.. ((cc) ) 55. . ((d)d) 6 6. . ((aa) ) 77. . ((b) b) 88.. ((bb) ) 99.. ((aa) ) 1100. . ((bb)) 1 11. 1. (b(b) ) 1212. . ((a) a) 1313.. (d) (d) 1414.. (c(c) ) 115. 5. (a(a)) 1 16. 6. (d(d) ) 1717. . ((a) a) 1818.. (c) (c) 119.9. ((b) b) 220. 0. (a(a)) 2

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1.

1. A suppository is generally intended forA suppository is generally intended for use in use in (a) Rectum (a) Rectum (b) Vagina (b) Vagina (c) Urethra (c) Urethra (d)

2. Vaginal suppositories also called asVaginal suppositories also called as (a) Pessaries

(a) Pessaries (b)

(b) Simple Simple suppositoriessuppositories (c) Bougies

(c) Bougies (d) None (d) None 3.

3. “Oleum theobromae” was first recom-“Oleum theobromae” was first recom-mended by

mended by (a) A.B.

(a) A.B. Taylor Taylor (b) (b) GriffinGriffin (c)

(c) Stocks’s Stocks’s (d) (d) NoneNone 4.

4. Weight of rectal suppository for adultsWeight of rectal suppository for adults is is (a) (a) 1 1 g g (b) (b) 2 2 gg (c) (c) 5 5 g g (d) (d) NoneNone 5.

5. Weight of rectal suppository forWeight of rectal suppository for children is children is (a) (a) 1 1 g g (b) (b) 2 2 gg (c) (c) 5 5 g g (d) (d) NoneNone 6.

6. Urethral suppositories also called asUrethral suppositories also called as (a)

(a) Pessaries Pessaries (b) (b) BougiesBougies (c)

7. Urethral suppositories having whichUrethral suppositories having which shape

shape (a)

(a) Oviform Oviform shapeshape (b)

(b) Torpedo Torpedo shapeshape (c)

(c) Pencil Pencil shapeshape (d) None

(d) None 8.

8. Weight of urethral suppository forWeight of urethral suppository for males & females respectively

males & females respectively (a)

(a) 4 4 & & 2 2 (b) (b) 2 2 & & 44 (c)

(c) 4 4 & & 6 6 (d) (d) 6 6 & & 44

9.

9. Shape of vaginal suppositories isShape of vaginal suppositories is (a)

(a) Oviform Oviform shapeshape (b)

(b) Torpedo Torpedo shapeshape (c)

(c) Pencil Pencil shapeshape (d) None

(d) None 10.

10. Rectal suppositories mainly used forRectal suppositories mainly used for the treatment of

the treatment of (a)

(a) Constipation Constipation (b) (b) HemorrhoidsHemorrhoids (c)

11. The number of milligrams of KOHThe number of milligrams of KOH required neutralizing free acids & required neutralizing free acids & saponify the esters contained in 1 g of saponify the esters contained in 1 g of fat is known as

fat is known as (a)

(a) Iodine Iodine valuevalue (b)

(b) Saponification Saponification valuevalue (c)

(c) Water Water numbernumber (d)

(d) Acid Acid valuevalue 12.

12. The number of grams of iodine thatThe number of grams of iodine that reacts with 100 g of fat is known as reacts with 100 g of fat is known as (a)

(c) Water Water numbernumber (d)

13. The number of milligrams of KOHThe number of milligrams of KOH required neutralizing free acids in 1 g required neutralizing free acids in 1 g of fat is known as

of fat is known as (

( a) a) Iodine Iodine valuevalue (b)

(c) Hydroxil Hydroxil valuevalue (d)

14. The number of milligrams of KOHThe number of milligrams of KOH required neutralize the acetic acid used required neutralize the acetic acid used to acetylate 1 g of fat is known as to acetylate 1 g of fat is known as (a)

(c) Hydroxil Hydroxil valuevalue (d)

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15.

15. Which of the following method is usedWhich of the following method is used to manufacture suppositories

to manufacture suppositories (a)

(a) Hand Hand moldingmolding (b)

(b) Compression Compression moldingmolding (c)

(c) Pour Pour moldingmolding (d)

16. Which of the following is mostWhich of the following is most commonly used suppository base

commonly used suppository base (a)

(a) Cocoa Cocoa butterbutter (b)

(b) PEG PEG 10001000 (c)

(c) PEG PEG + + HexanetriolHexanetriol (d) None

(d) None 17.

17. Cocoa butter available in followingCocoa butter available in following forms

forms (a)

(a) αα-form -form (b)(b) ββ-form-form (c)

(c) γγ-form -form (d) (d) AllAll 18.

18. The solidification point of cocoa butterThe solidification point of cocoa butter lies between lies between (a) (a) 12 12 – – 1313oo (b) (b) 20 20 – – 3030oo (c) (c) 5 5 – – 1010oo (d) (d) NoneNone 19.

19. Which of the following method isWhich of the following method is simple & oldest method of preparation simple & oldest method of preparation of suppositories?

of suppositories? (a)

(a) Hand Hand moldingmolding (b)

20. Most commonly used method forMost commonly used method for produ

producing cing supposisuppositories tories on on both both aa small & large scale is

small & large scale is (a)

(a) Hand Hand moldingmolding

(b)

21. Which formula can be used toWhich formula can be used to calculate the amount of base that is calculate the amount of base that is replaced by active ingredients?

replaced by active ingredients? (a) (a) ff ==10100 0 (G(G –– E)E)++11 (G) (X) (G) (X) (b) (b) ff ==10100 0 (E(E –– G)G)++110000 (G) (X) (G) (X) (c) (c) ff ==10100 0 (E(E –– G)G)++11 (G) (X) (G) (X) (d) (d) ff ==10100 0 (E(E –– G)G)++1100 (G) (X) (G) (X) 22.

22. Rancidity generally results fromRancidity generally results from (a)

(a) Auto Auto oxidationoxidation (b)

(b) Decomposition Decomposition of of unsaturatedunsaturated fats fats (c) Both (c) Both (d) None (d) None 23.

23. Which of the following is not antioxi-Which of the following is not antioxi-dant

dant (a)

(a) BHT BHT (b) (b) BHABHA (c) Tocopherol

(c) Tocopherol (d) Theobroma (d) Theobroma oiloil

24.

24. Suppositories are generally evaluatedSuppositories are generally evaluated by

by (a)

(a) Melting Melting range range testtest (b)

(b) Breaking Breaking testtest (c) Liquefaction (c) Liquefaction (d)

KEY KEY

1

1. . ((dd) ) 22. . ((aa) ) 33.. ((aa) ) 44.. ((b) b) 55. . ((aa)) 6

6. . ((bb) ) 77. . ((cc) ) 88.. ((aa) ) 99.. ((aa) ) 1100. . ((cc)) 1

11. 1. (b(b) ) 112. 2. ((a) a) 113.3. (d(d) ) 1414.. (c(c) ) 1515. . (d(d)) 1

16. 6. (a(a) ) 117. 7. (d(d) ) 1818.. (a(a) ) 1919.. (a(a) ) 2020. . (c(c)) 2

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1.

1. Which of the following materials areWhich of the following materials are used in pharmaceutical packaging? used in pharmaceutical packaging? (a) Glass (a) Glass (b) Plastic (b) Plastic (c) Metal (c) Metal (d)

2.

2. Which of the following packagingWhich of the following packaging material is protect the drug content material is protect the drug content against light

against light (a)

(a) Plastic Plastic containerscontainers (b)

(b) Amber Amber colored colored glass glass containerscontainers (c) Both

3.

3. Major disadvantages of glass as aMajor disadvantages of glass as a pack

packing ming materiaterial aral aree (a)

(a) Fragility Fragility (b) (b) WeightWeight (c)

4.

4. Composition of glass isComposition of glass is (a) Sand

(a) Sand (b)

(b) Soda Soda ashash (c)

(c) Lime Lime stone stone & & CulletCullet (d)

5.

5. Soda ash also known asSoda ash also known as (a)

(a) Pure Pure silicasilica (b)

(b) Sodium Sodium carbonatecarbonate (c)

(c) Lime Lime stonestone (d)

(d) Calcium Calcium carbonatecarbonate

6.

6. Which of the following one is a brokenWhich of the following one is a broken glass & acts as fusion agent

glass & acts as fusion agent (a)

(a) Cullet Cullet (b) (b) Soda Soda ashash (c)

(c) Lime Lime stone stone (d) (d) SandSand

7.

7. Which of the following methods areWhich of the following methods are used in the production of glass

used in the production of glass (a) Blowing

(a) Blowing (b) Drawing (b) Drawing (c)

(c) Pressing Pressing & & castingcasting (d)

8.

8. To produce molten glass, which of theTo produce molten glass, which of the following method is used

following method is used (a)

(a) Blowing Blowing (b) (b) DrawingDrawing (c)

(c) Pressing Pressing (d) (d) CastingCasting

9.

9. To protect the contents of a bottle fromTo protect the contents of a bottle from the effects of sunlight by UV rays, the effects of sunlight by UV rays, which glass is used?

which glass is used? (a)

(a) Amber Amber glass glass (b) (b) Red Red glassglass (c)

10.

10. To evaluate the chemical resistance ofTo evaluate the chemical resistance of glass, which of the following tests are glass, which of the following tests are conducted?

conducted? (a)

(a) Powder Powder glassglass (b)

(b) Water Water attack attack testtest (c) Both

11.

11. Which of the following test isWhich of the following test is perf

performed ormed on on cruscrushed hed graingrains, s, toto evaluate the chemical resistance of evaluate the chemical resistance of glass?

glass? (a)

12.

12. Which of the following test isWhich of the following test is perfo

performed rmed on whoon whole cole containentainer?r? (a)

13.

13. Type I glass is also known asType I glass is also known as (a)

(a) Borosilicate Borosilicate glassglass (b)

(b) Regular Regular soda-lime soda-lime glassglass (c)

(c) Treated Treated soda-lime soda-lime glassglass (d) None

(10)

14.

14. The advantages of plastic containersThe advantages of plastic containers over glass containers are

over glass containers are (a)

(a) Easy Easy formationformation (b)

(b) Resistance Resistance to to breakagebreakage (c)

(c) Freedom Freedom of of designdesign (d)

15.

15. Plastic containers are generally madePlastic containers are generally made from the following material

from the following material (a) Polyethylene (a) Polyethylene (b) Polypropylene (b) Polypropylene (c) Polystyrene (c) Polystyrene (d)

16.

16. Which of the following ingredients areWhich of the following ingredients are pres

present in ent in rubberubber stopr stopper?per? (a)

(a) Vulcanizing Vulcanizing agentagent (b) Softner

(b) Softner (c) Antioxidant (c) Antioxidant (d)

17.

17. Which of the following packagingWhich of the following packaging systems are identified by the FDA? systems are identified by the FDA? (a)

(a) Blister Blister packpack (b)

(b) Strip Strip packpack

(c)

(c) Bubble Bubble packpack (d)

18.

18. Which of the following packaging isWhich of the following packaging is commonly used for packaging of commonly used for packaging of tablets & capsules?

tablets & capsules? (a)

(a) Blister Blister pack pack (b) Strip (b) Strip packpack (c)

19.

19. Which of the following materials offerWhich of the following materials offer moisture barrier properties?

moisture barrier properties? (a) Aclar (a) Aclar (b) Cellophane (b) Cellophane (c) Polyester (c) Polyester (d)

20.

20. Which of the following mechanism isWhich of the following mechanism is responsible for release of encapsulated responsible for release of encapsulated core materials?

core materials? (a)

(a) By By disrupting disrupting the the coating coating byby pressure

pressure (b)

(b) By By offering offering permeabilitypermeability facilities

facilities (c)

(c) By By leaching leaching of of permanenpermanent t fluidfluid (d)

KEY KEY 1 1. . ((dd) ) 22. . ((bb) ) 33.. ((cc) ) 44.. ((dd) ) 55. . ((bb)) 6 6. . ((aa) ) 77. . ((dd) ) 88.. ((aa) ) 99.. ((cc) ) 1100. . ((cc)) 11 11. . (a(a) ) 1212. . (b(b) ) 113.3. (a(a) ) 1414.. (d(d) ) 1515. . (d(d)) 16 16. . (d(d) ) 1717. . ((d) d) 118.8. (b(b) ) 1919.. (d(d) ) 2020. . (d(d))

(11)

1.

1. Pre - formulation studies mainly focusPre - formulation studies mainly focus on

on (a)

(a) Physical Physical properties properties of of newnew compound

compound (b)

(b) Chemical Chemical properties oproperties of newf new compound

compound (c)

(c) Physico-chemPhysico-chemical ical properties properties ofof new compound

new compound (d) None

(d) None

2.

2. Which of the following information isWhich of the following information is helpful in designing the pre-helpful in designing the pre-formulation evaluation of a new drug? formulation evaluation of a new drug? (a)

(a) Structure Structure of of a a compoundcompound (b)

(b) Formula & Formula & molecular molecular weight of aweight of a compound

compound (c)

(c) TherapeuTherapeutic tic indication indication of of a a newnew compound

compound (d)

3.

3. Which of the following problemsWhich of the following problems commonly encountered in evaluating commonly encountered in evaluating salt forms are

salt forms are (a)

(a) Poor Poor crystallinitycrystallinity (b) Hygroscopicity (b) Hygroscopicity (c) Instability (c) Instability (d)

4.

4. Which of the following salts generallyWhich of the following salts generally used in pharmaceutical products?

used in pharmaceutical products? (a) Acetate (a) Acetate (b) Gluconate (b) Gluconate (c) Lactate (c) Lactate (d)

5.

5. Description of the outer appearance ofDescription of the outer appearance of a crystal is known as

a crystal is known as (a)

(a) Crystal Crystal habithabit (b)

(b) Internal Internal structurestructure (c) Both

6.

6. Which of the following techniquesWhich of the following techniques used to prepare amorphous forms? used to prepare amorphous forms? (a)

(a) Rapid Rapid precipitationprecipitation (b) Lyophilization (b) Lyophilization (c)

(c) Rapid Rapid coolingcooling (d)

7.

7. Amorphous forms generally havingAmorphous forms generally having (a)

(a) Low Low thermodynamic thermodynamic energy energy && low solubility

low solubility (b)

(b) High High thermodynathermodynamic mic energy energy && high solubility high solubility (c) Both (c) Both (d) None (d) None 8.

8. Which of the following compoundWhich of the following compound posse

possess hiss high aqugh aqueous seous solubilitolubility’s?y’s? (a)

(a) Hydrates Hydrates (b) (b) AnhydratesAnhydrates (c)

9.

9. Which of the following properties mayWhich of the following properties may change with changing of the internal change with changing of the internal structure of a solid?

structure of a solid? (a)

(a) Melting Melting pointpoint (b) Density (b) Density (c)

(c) Optical Optical propertiesproperties (d)

10.

10. Which of the following methodsWhich of the following methods generally used for studying solid generally used for studying solid forms? forms? (a) DSC (a) DSC (b) XRD (b) XRD (c) TGA (c) TGA (d)

11.

11. Which of the following methodsWhich of the following methods generally used to measure heat loss or generally used to measure heat loss or gain within a sample?

gain within a sample? (a)

(a) DSC DSC (b) (b) DTADTA (c)

(12)

12.

12. Which of the following co-solvent canWhich of the following co-solvent can be

be used used to to increincrease ase the the solubsolubility ility ofof poor

poor soluble soluble drugs?drugs? (a) Ethanol

(a) Ethanol (b)

(b) Propylene Propylene glycolglycol (c) Glycerin

(c) Glycerin (d)

13.

13. Partition Partition co-efficient co-efficient generallygenerally measures

measures (a)

(a) Drug’s Drug’s lipophilicitylipophilicity (b)

(b) Ability Ability of of drug drug to to cross cross cellcell membrane membrane (c) Both (c) Both (d) None (d) None 14.

14. Dissolution of a drug particle isDissolution of a drug particle is described by

described by (a)

(a) Noyes-Whitney Noyes-Whitney equationequation (b)

(b) Stock’s Stock’s equationequation (c)

(c) Drag’s Drag’s equationequation (d) None

(d) None

15.

15. The effect of temperature on drugThe effect of temperature on drug stability can be described by

stability can be described by (a)

(a) Noyes-WhitneNoyes-Whitney y equationequation (b)

(b) Stock’s Stock’s equationequation (c)

(c) Arheneous Arheneous equationequation (d) None (d) None KEY KEY 1 1. . ((cc) ) 22. . ((dd) ) 33.. ((d) d) 44.. ((d) d) 55. . ((aa)) 6 6. . ((dd) ) 77. . ((bb) ) 88.. ((bb) ) 99.. ((d) d) 1100. . ((d)d) 11 11. . (c(c) ) 1212. . (d(d) ) 113.3. (c(c) ) 1414.. ((a) a) 115. 5. (d(d))

(13)

1.

1. Unequal distribution of color on aUnequal distribution of color on a tablet, refers to

tablet, refers to (a)

(a) Picking Picking (b) (b) MottlingMottling (c)

(c) Capping Capping (d) (d) StickingSticking 2.

2. Match the following and find out theMatch the following and find out the correct combination

correct combination 1. Capping

1. Capping (P)

(P) Separation Separation of a of a tablet tablet into 2 into 2 oror more layers

more layers 2. Lamination 2. Lamination

(Q)

(Q) Unequal Unequal distribution odistribution of colf coloror on a tablet

on a tablet 3. Mottling

3. Mottling (R)

(R) Separation Separation of of top/bottomtop/bottom crowns of a tablet from the crowns of a tablet from the main body

main body 4. Sticking

4. Sticking (S)

(S) Adherence Adherence of of tablet tablet materialmaterial to the die wall

to the die wall (a) (a) 2-P, 2-P, 3-Q, 3-Q, 1-R, 1-R, 4-S4-S (b) (b) 1-P, 1-P, 2-Q, 2-Q, 3-R, 3-R, 4-S4-S (c) (c) 3-P, 3-P, 1-Q, 1-Q, 2-R, 2-R, 4-S4-S (d) (d) 4-P, 4-P, 1-Q, 1-Q, 3-R, 3-R, 2-S2-S 3.

3. Which of the following one isWhich of the following one is responsible for sticking?

responsible for sticking? (a)

(a) Excessive Excessive moisturemoisture (b)

(b) Low Low moisturemoisture (c) Both

4. Which of the following mixer is a firstWhich of the following mixer is a first high shear powder blender/mixer

high shear powder blender/mixer (a)

(a) Diosna Diosna mixermixer (b)

(b) Littleford Littleford lodige lodige mixermixer (c)

(c) Plow Plow mixermixer (d)

(d) Gral Gral mixermixer

5.

5. If the dose of a drug is inadequate, thenIf the dose of a drug is inadequate, then it generally requires the following one, it generally requires the following one, to make up its bulk

to make up its bulk (a) Binders (a) Binders (b) Disintegrants (b) Disintegrants (c) Lubricants (c) Lubricants (d) Diluents (d) Diluents 6.

6. The first and most widely used diluentThe first and most widely used diluent in tablet formulation is

in tablet formulation is (a)

(a) Dextrose Dextrose (b) Lactose(b) Lactose (c)

(c) MCC MCC (d) (d) StarchStarch 7.

7. Anhydrous lactose has the advantageAnhydrous lactose has the advantage over hydrous lactose

over hydrous lactose (a)

(a) Improved Improved flowflow (b)

(b) Absence Absence of of millard millard reactionreaction (c)

(c) Improved Improved compressibilitycompressibility (d)

(d) High High microbial microbial loadload 8.

8. Which of the following is not aWhich of the following is not a commercially available starch product? commercially available starch product? (a) Sta-Rx

(a) Sta-Rx 1500 1500 (b) Celutab(b) Celutab (c)

(c) Emdex Emdex (d) (d) Sugar Sugar tabtab 9.

9. Which of the following is a syntheticWhich of the following is a synthetic adhesive? adhesive? (a) (a) PVP PVP (b) (b) MCMC (c) (c) HPMC HPMC (d) (d) HPCHPC 10.

10. Which of the following is a waterWhich of the following is a water soluble lubricant?

soluble lubricant? (a)

(a) Stearic Stearic acidacid (b)

(b) Mineral Mineral oiloil (c) PEG

(c) PEG (d)

(14)

11.

11. Find out the correct statementsFind out the correct statements regarding a sweetener, saccharin

regarding a sweetener, saccharin

(P) It is 500 times sweeter than (P) It is 500 times sweeter than

sucrose, but it is

sucrose, but it is carcinogeniccarcinogenic (Q) It is 500 times sweeter than (Q) It is 500 times sweeter than

sucrose, but it has bitter taste sucrose, but it has bitter taste (R)

(R) It is It is sweeter sweeter than than sucrose, sucrose, but itbut it is safe

is safe (S)

(S) It is sweIt is sweeter than eter than sucrose, sucrose, but itbut it is unstable is unstable (a) (a) P, P, S S (b) (b) P, P, RR (c) (c) P, P, Q Q (d) (d) R, R, SS 12.

12. Aerosil is used asAerosil is used as (a)

(a) Glidant Glidant (b) (b) LubricantLubricant (c)

(c) AntiadheranAntiadherant t (d) (d) NoneNone 13.

13. What is the pH of duodenum?What is the pH of duodenum? (a)

(a) 2-3 2-3 (b) (b) 7-87-8 (c)

(c) 4-6 4-6 (d) (d) 1010 14.

14. Tablets, which are placed betweenTablets, which are placed between cheek and teeth, are known as

cheek and teeth, are known as (a)

(a) Buccal Buccal (b) (b) SublingualSublingual (c)

(c) Lozenges Lozenges (d) (d) TrochesTroches 15.

15. Which statement is not correct?Which statement is not correct? (a)

(a) Buccal Buccal routes routes avoids avoids first first passpass metabolism

metabolism ( b)

( b) Parenteral Parenteral route avoids route avoids first passfirst pass metabolism

metabolism (c)

(c) Sublingual Sublingual route route avoids avoids first first passpass metabolism

metabolism (d)

(d) Oral Oral route route avoids avoids first first passpass metabolism

metabolism 16.

16. Match the following ingredientsMatch the following ingredients according to their purpose in the according to their purpose in the formulation of tablets and find out the formulation of tablets and find out the correct set

correct set 1. Glidant 1. Glidant

(P)

(P) Pre- Pre- gelatinized gelatinized starchstarch

2. Diluent 2. Diluent (Q) Pyramine (Q) Pyramine 3. Adherent 3. Adherent (R)

(R) Colloidal Colloidal silicasilica 4. Disintegrant

4. Disintegrant (S)

(S) Calcium Calcium sulphatesulphate (T)

(T) Sodium Sodium alginatealginate (a) (a) 1-R, 1-R, 2-S, 2-S, 3-P, 3-P, 4-T4-T (b) (b) 1-S, 1-S, 2-R, 2-R, 3-Q, 3-Q, 4-P4-P (c) (c) 1-R, 1-R, 2-S, 2-S, 3-T, 3-T, 4-Q4-Q (d) (d) 1-Q, 1-Q, 2-T, 2-T, 3-R, 3-R, 4-P4-P 17.

17. Enteric coating is achieved by usingEnteric coating is achieved by using (a)

(a) HPMC HPMC (b) (b) CMCCMC (c)

(c) CAP CAP (d) (d) PovidinePovidine 18.

18. The disintegration time for sugarThe disintegration time for sugar coated tablets is

coated tablets is (a) 30

(a) 30 minutes minutes (b) 45 (b) 45 minutesminutes (c) 60

(c) 60 minutes minutes (d) 75 minutes(d) 75 minutes 19.

19. Flow rate of granules from the hopperFlow rate of granules from the hopper can be improved by adding

can be improved by adding (a)

(a) Disintegrant Disintegrant (b) (b) GlidantGlidant (c)

(c) Binder Binder (d) Lubricant(d) Lubricant 20.

20. Given below are equipment used in theGiven below are equipment used in the manufacture of following products manufacture of following products P-T. Match them and find out correct T. Match them and find out correct answer

answer 1. Zenasi 1. Zenasi (P)

(P) Tablet Tablet granulesgranules 2.

2. Hepa Hepa filterfilter (Q)

(Q) Tablet Tablet coatingcoating 3. Chilsonator

3. Chilsonator (R) Emulsion (R) Emulsion 4.

4. Accela Accela cotacota (S) Injectables (S) Injectables (T) Capsule (T) Capsule

(15)

(a) (a) 1-T, 1-T, 2-S, 2-S, 3-P, 3-P, 4-Q4-Q (b) (b) 1-P, 1-P, 2-Q, 2-Q, 3-S, 3-S, 4-R4-R (c) (c) 1-T, 1-T, 2-R, 2-R, 3-Q, 3-Q, 4-P4-P (d) (d) 1-S, 1-S, 2-R, 2-R, 3-P, 3-P, 4-Q4-Q 21.

21. Match the ingredients according toMatch the ingredients according to their purpose in the formulation and their purpose in the formulation and find out correct set

find out correct set 1.

1. Film Film coatingcoating (P)

(P) Sodium Sodium benzoatebenzoate 2. Syrups

2. Syrups (Q)

(Q) Ethyl Ethyl cellulosecellulose 3. Emulsification 3. Emulsification (R) Eudragit (R) Eudragit 4. Enteric coating 4. Enteric coating (S) Sucrose (S) Sucrose (T)

(T) Sodium Sodium oleateoleate (a) (a) 1-P, 1-P, 2-Q, 2-Q, 3-R, 3-R, 4-S4-S (b) (b) 1-R, 1-R, 2-S, 2-S, 3-T, 3-T, 4-Q4-Q (c) (c) 1-T, 1-T, 2-P, 2-P, 3-S, 3-S, 4-Q4-Q (d) (d) 1-R, 1-R, 2-S, 2-S, 3-Q, 3-Q, 4-T4-T 22.

22. Match the following regions in GITMatch the following regions in GIT with the pH levels indicated from P-T with the pH levels indicated from P-T and find out correct answer

and find out correct answer 1. Mouth 1. Mouth (P) 5-6 (P) 5-6 2. Stomach 2. Stomach (Q) 6.8-7.5 (Q) 6.8-7.5 3. Deodenum 3. Deodenum (R) 6.8-7 (R) 6.8-7 4.

4. Large Large intestineintestine (S) 3-5 (S) 3-5 (T) 1.5-3 (T) 1.5-3 (a) (a) 1-Q, 1-Q, 2-T, 2-T, 3-S, 3-S, 4-R4-R (b) (b) 1-P, 1-P, 2-R, 2-R, 3-S, 3-S, 4-T4-T (c) (c) 1-S, 1-S, 2-T, 2-T, 3-Q, 3-Q, 4-R4-R (d) (d) 1-R, 1-R, 2-S, 2-S, 3-T, 3-T, 4-P4-P 23.

23. In sugar coating of tablets, sub- coatingIn sugar coating of tablets, sub- coating is done

is done (a)

(a) To To prevent prevent moisture moisture absorptionabsorption (b)

(b) To rounTo round the d the edge & edge & build tablebuild tablett size

size (c)

(c) To To smoothen smoothen the the surfacesurface (d)

(d) To To prevent the prevent the tablet fromtablet from breaking due to vibra

breaking due to vibrationtion 24.

24. Some possible causes are mentioned inSome possible causes are mentioned in P-T, for the following defects during P-T, for the following defects during the film coating of tablets. Match them the film coating of tablets. Match them

1. Chipping 1. Chipping

(P)

(P) Poor Poor spreading spreading duringduring spraying

spraying 2. Cracking 2. Cracking

(Q)

(Q) Over Over heating heating duringduring spraying

spraying 3.

3. Orange Orange peelpeel (R)

(R) Higher Higher internal internal stresses stresses inin film

film 4. Blistering 4. Blistering

(S)

(S) Excessive Excessive coating coating processprocess (T)

(T) Precipitation Precipitation of pof polymer olymer duedue to high

to high temperaturtemperature/poore/poor solvent solvent (a) (a) 1-S, 1-S, 2-R, 2-R, 3-P, 3-P, 4-Q4-Q (b) (b) 1-T, 1-T, 2-S, 2-S, 3-R, 3-R, 4-P4-P (c) (c) 1-P, 1-P, 2-Q, 2-Q, 3-R, 3-R, 4-S4-S (d) (d) 1-R, 1-R, 2-P, 2-P, 3-Q, 3-Q, 4-T4-T 25.

25. Sub coating is given to the tabletsSub coating is given to the tablets (a)

(a) To To increase increase the the bulkinessbulkiness (b)

(b) To To avoid avoid deterioration deterioration due due toto microbial attack

microbial attack (c)

(c) To To prevent prevent the the solubility solubility in in acidicacidic medium

medium (d)

(16)

26.

26. The The following following ingredients ingredients areare commonly used as coating agents for commonly used as coating agents for film coating except

film coating except (a) CAP

(a) CAP (b)

(b) Carnauba Carnauba waxwax (c) HEC

(c) HEC (d)

(d) Sodium Sodium CMCCMC 27.

27. The ingredients mentioned in P-S areThe ingredients mentioned in P-S are used in various stages of sugar coating used in various stages of sugar coating of tablets. Match them and find out of tablets. Match them and find out correct answer

correct answer 1.

1. Seal Seal coatingcoating (P) Gelatin (P) Gelatin 2.

2. Sub Sub coatingcoating (Q)

(Q) Carnauba Carnauba waxwax 3.

3. Syrup Syrup coatingcoating (R)

(R) PEG PEG 40004000 4. Polyshing

4. Polyshing (S)

(S) Cane Cane sugarsugar (a) (a) 1-S, 1-S, 2-P, 2-P, 3-R, 3-R, 4-Q4-Q (b) (b) 1-Q, 1-Q, 2-S, 2-S, 3-R, 3-R, 4-P4-P (c) (c) 1-P, 1-P, 2-Q, 2-Q, 3-R, 3-R, 4-S4-S (d) (d) 1-R, 1-R, 2-P, 2-P, 3-Q, 3-Q, 4-S4-S 28.

28. The courster process can be used toThe courster process can be used to (a)

(a) Coat Coat tabletstablets (b)

(b) Determine Determine the the disintegration disintegration timetime (c)

(c) Gas Gas sterilize sterilize parenteraparenteral l solutionsolution (d)

(d) Automatic Automatic filling filling of of capsulescapsules 29.

29. Which of the following is the firstWhich of the following is the first proc

process ess that that must occur must occur beforbefore e a a drugdrug can become available for absorption can become available for absorption from a tablet dosage form?

from a tablet dosage form? (a)

(a) Dissolution Dissolution of of the the drug drug in in GIGI fluids

fluids (b)

(b) Dissolution Dissolution of of the the drug drug inin epithelium

epithelium (c)

(c) Ionization Ionization of of the the drugdrug (d)

(d) Disintegration Disintegration of of the the drugdrug

30.

30. Tablets are placed into coatingTablets are placed into coating chamber & hot air is introduced chamber & hot air is introduced through the bottom of the chamber. through the bottom of the chamber. Coating solution is applied through an Coating solution is applied through an atomizing nozzle from the upper end atomizing nozzle from the upper end of the chamber. This technique is of the chamber. This technique is called

called (a)

(a) Sealing Sealing before before sugar sugar coatingcoating (b)

(b) Coating Coating by by air air suspensionsuspension (c)

(c) Spray-pan Spray-pan coatingcoating (d)

(d) Chamber Chamber coatingcoating 31.

31. A synthetic sweetening agent which isA synthetic sweetening agent which is approximately 200 times sweeter than approximately 200 times sweeter than sucrose & has no taste is

sucrose & has no taste is (a)

(a) Saccharin Saccharin (b) (b) AspartameAspartame (c)

(c) Cyclamate Cyclamate (d) (d) SorbitolSorbitol 32.

32. Shellac is used the purpose of coatingShellac is used the purpose of coating tablets as

tablets as (a)

(a) Polishing Polishing agentagent (b)

(b) Film Film coating coating agentagent (c)

(c) Enteric Enteric coating coating agentagent (d)

(d) Sub-coating Sub-coating agent agent for for sugarsugar coating

coating 33.

33. Dose dumping is a problem in theDose dumping is a problem in the formulation of

formulation of (a)

(a) CompresseCompressed d tabtab (b) Suppository (b) Suppository (c)

(c) Soft Soft gelatin gelatin capsulescapsules (d)

(d) Controlled Controlled release release drug drug productsproducts 34.

34. Select the equation that gives the rateSelect the equation that gives the rate of drug dissolution from a tablet

of drug dissolution from a tablet (a)

(a) Fick’s Fick’s lawlaw (b)

(b) Henderson-HaHenderson-Hasselbatch sselbatch equationequation (c)

(c) Noyes-Whitney Noyes-Whitney equationequation (d)

(17)

35.

35. Which of the following substance isWhich of the following substance is used as muco adhesive

used as muco adhesive (a) Acacia

(a) Acacia (b)

(b) Sodium Sodium CMCCMC (c)

(c) Burnt Burnt sugarsugar (d) Saccharin (d) Saccharin 36.

36. In the preparation of multi layerIn the preparation of multi layer tablets, one of the following is used for tablets, one of the following is used for hydrophilic matrix coating

hydrophilic matrix coating (a) Shellac

(a) Shellac (b) CMC (b) CMC (c)

(c) Stearyl Stearyl alcoholalcohol (d)

(d) Bees Bees waxwax 37.

37. The diameter of the mesh aperture inThe diameter of the mesh aperture in the I.P. disintegration apparatus is the I.P. disintegration apparatus is given below. Choose the correct size given below. Choose the correct size (a)

(a) 2 2 mm mm (b) (b) 4 4 mmmm (c)

(c) 1mm 1mm (d) (d) 1.50 1.50 mmmm 38.

38. Diclofenac tablet with CAP has beenDiclofenac tablet with CAP has been administered to a patient. Where do administered to a patient. Where do you expect the drug

you expect the drug to be released?to be released? (a)

(a) Stomach Stomach (b) (b) Oral Oral cavitycavity (c)

(c) Small Small intestine intestine (d) (d) LiverLiver 39.

39. Which of the following flavor is usedWhich of the following flavor is used in a formulation containing sour taste? in a formulation containing sour taste? (a) Wild

(a) Wild cherry cherry (b) (b) VanillaVanilla (c)

(c) Citrus Citrus (d) (d) ChocolateChocolate 40.

40. Durability of a tablet to combinedDurability of a tablet to combined effects of shock & abrasion is effects of shock & abrasion is evaluated by using

evaluated by using (a)

(a) Hardness Hardness testertester (b)

(b) Disintegration Disintegration test test apparatusapparatus (c) Friabilator

(c) Friabilator (d)

(d) Screw Screw guageguage

41.

41. A retardant material that forms aA retardant material that forms a hydrophilic matrix in the formulation hydrophilic matrix in the formulation of matrix tablets is of matrix tablets is (a) HPMC (a) HPMC (b) CAP (b) CAP (c) Polyethylene (c) Polyethylene (d)

(d) Carnauba Carnauba waxwax 42.

42. A water soluble substance used asA water soluble substance used as coating material in micro coating material in micro encapsulation process is

encapsulation process is (a)

(a) Polyethylene Polyethylene (b) (b) SiliconeSilicone (c)

(c) HEC HEC (d) (d) ParaffinParaffin 43.

43. One of the following is used as a pOne of the following is used as a pHH dependant controlled release excipient dependant controlled release excipient (a)

(a) Carnauba Carnauba waxwax (b) HPMCP (b) HPMCP (c) MC (c) MC (d)

(d) Glyceryl Glyceryl mono mono stearatestearate 44.

44. In In the the tablet tablet coating coating process,process, inadequate spreading of coating inadequate spreading of coating solution before drying causes

solution before drying causes (a)

(a) Orange Orange peel peel effecteffect (b)

(b) Sticking Sticking effecteffect (c)

(c) Blistering Blistering effecteffect (d)

(d) Picking Picking effecteffect 45.

45. Crown thickness of a tablet isCrown thickness of a tablet is measured by measured by (a) Micrometer (a) Micrometer (b) Pychnometer (b) Pychnometer (c) Hydrometer (c) Hydrometer (d)

46. Friabilator is operated atFriabilator is operated at (a)

(a) 100 100 RPM RPM (b) (b) 75 75 RPMRPM (c)

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47.

47. Enteric coated tablet disintegrate inEnteric coated tablet disintegrate in ……hours in simulated intestinal fluid ……hours in simulated intestinal fluid (a)

(a) 1 1 (b) (b) 22 (c)

(c) 3 3 (d) (d) 44 48.

48. In dissolution test, flask is maintainedIn dissolution test, flask is maintained at at (a) 37 (a) 37ooC ± 0.5C ± 0.5ooC C (b) (b) 4141ooC ± 1C ± 1ooCC (c) 39 (c) 39ooC ± 0.6C ± 0.6ooC C (d) (d) 4040ooC ± 1C ± 1ooCC 49.

49. Capping is prevented by using one ofCapping is prevented by using one of the following punches

the following punches (a)

(a) Flat Flat (b) (b) CircularCircular (c)

(c) Square Square (d) Rectangular(d) Rectangular 50.

50. Plating of punch faces are done byPlating of punch faces are done by (a)

(a) Chromium Chromium (b) (b) ZincZinc (c)

(c) Iron Iron (d) (d) AllAll 51.

51. Sta-Rx-1500 contains ……% ofSta-Rx-1500 contains ……% of moisture moisture (a) (a) 15 15 (b) (b) 1010 (c) (c) 18 18 (d) (d) 5050 52.

52. Acacia trgacanth is used in theAcacia trgacanth is used in the concentration of concentration of (a) 10%-25 (a) 10%-25 % % (b) (b) 60%-70 60%-70 %% (c) (c) 40%-50 40%-50 % % (d) (d) 90%90% 53.

53. Starch on heating hydrolyze intoStarch on heating hydrolyze into (a) Glucose

(a) Glucose (b)

(b) Fructose Fructose & & SorboseSorbose (c)

(c) Fructose Fructose & & MannoseMannose (d)

(d) Dextrin Dextrin & & GlucoseGlucose 54.

54. PPHH of the small intestine is of the small intestine is (a)

(a) 1-2 1-2 (b) (b) 3-43-4 (c)

(c) 6 6 (d) (d) 7-87-8 55.

55. Aqua coat is aAqua coat is a (a)

(a) 30% 30% w/v w/v of of ethyl ethyl cellulosecellulose dispersion

dispersion (b)

(b) Solution Solution of of HPMCHPMC

(c)

(c) 2% 2% w/v w/v of of methyl methyl cellulosecellulose dispersion

dispersion (d) None (d) None 56.

56. Lozenges were originally named asLozenges were originally named as (a) Capsule (a) Capsule (b) ODT (b) ODT (c) Pastillies (c) Pastillies (d)

(d) Sustained Sustained axn axn tabtab 57.

57. Implantation tab are NMT……..mm inImplantation tab are NMT……..mm in length length (a) (a) 20 20 (b) (b) 100100 (c) (c) 40 40 (d) (d) 88 58.

58. Seal coating is done by usingSeal coating is done by using (a)

(a) Shellac Shellac (b) (b) AcaciaAcacia (c)

(c) Gelatin Gelatin (d) (d) NoneNone 59.

59. Sub coating is done toSub coating is done to (a)

(a) Round Round the the edgesedges (b)

(b) Increase Increase the the bulk bulk of of tablettablet (c)

(c) Both Both a a & & bb (d)

(d) Make Make water water resistantresistant 60.

60. CAP dissolves at PCAP dissolves at PHH (a)

(a) Above Above 6 6 (b) (b) Below Below 66 (c)

(c) 4 4 (d) (d) 22 61.

61. Which of the following one is used asWhich of the following one is used as opacifier opacifier (a) TiO (a) TiO22 (b) Mgo (b) Mgo (c) Siliactes (c) Siliactes (d)

(d) All All of of the the aboveabove 62.

62. Green bone is a source ofGreen bone is a source of (a)

(a) Type Type A A GelatinGelatin (b)

(b) Type Type B B GelatinGelatin (c) Both

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63.

63. Empty capsule has moisture content inEmpty capsule has moisture content in the range of the range of (a) (a) 60% 60% (b) (b) 12%-15 12%-15 %% (c) (c) 50%- 50%- 70% 70% (d) 30%(d) 30% 64.

64. Which treatment is used for solubilityWhich treatment is used for solubility of gelatin

of gelatin (a)

(a) Heat Heat (b) (b) FormalinFormalin (c)

(c) Water Water (d) (d) AlcoholAlcohol 65.

65. Which of the following is used to fillWhich of the following is used to fill powde

powdered red dry dry solid solid into into soft soft gelatgelatinin capsule

capsule (a)

(a) Aceo Aceo gel gel (b) (b) RotobilRotobil (c)

(c) Rotosort Rotosort (d) (d) RotoweighRotoweigh 66.

66. Sealing of capsule is achieved bySealing of capsule is achieved by (a) 100

(a) 100ooC C (b) (b) 2020ooCC (c) 37

(c) 37ooC-40C-40ooC C (d) (d) 7070ooCC 67.

67. Moisture content is determined byMoisture content is determined by (a)

(a) Gas Gas ChromatographChromatographyy (b) (b) K-F K-F MethodMethod (c) Both (c) Both (d) None (d) None 68.

68. Foam stability is measured byFoam stability is measured by (a)

(a) IR IR SpectroscopySpectroscopy (b)

(b) UV UV SpectroscopSpectroscopyy (c)

(c) Rotational Rotational viscometerviscometerss (d) All

(d) All 69.

69. Particle size is determined byParticle size is determined by (a)

(a) Gas Gas ChromatographyChromatography (b)

(b) Cascade Cascade impactorimpactor (c)

(c) Light Light scatter scatter decaydecay (d)

(d) Both Both b b & & cc 70.

70. Chewable tablet contains the followingChewable tablet contains the following base

base (a)

(a) Manitol Manitol (b) (b) GlucoseGlucose (c)

(c) Lactose Lactose (d) (d) NoneNone 71.

71. Which of the following is not added inWhich of the following is not added in lozenges?

lozenges? (a)

(a) SweeteneSweetener r (b) (b) BinderBinder (c)

(c) Disintegrant Disintegrant (d) (d) AllAll 72.

72. Enteric coated tablet is disintegrated inEnteric coated tablet is disintegrated in (a)

(a) Stomach Stomach (b) (b) LiverLiver (c)

(c) Intestine Intestine (d) (d) MouthMouth

KEY KEY 1 1. . ((bb) ) 22. . ((cc) ) 33.. ((aa) ) 44.. ((b) b) 55. . ((dd)) 6 6. . ((bb) ) 77. . ((b) b) 88.. ((dd) ) 99.. ((aa) ) 1100. . ((cc)) 1 11. 1. (c(c) ) 1212. . (a(a) ) 1313.. (c(c) ) 114.4. ((a) a) 115. 5. (d(d)) 1 16. 6. (a(a) ) 117. 7. (c(c) ) 1818.. (c(c) ) 119.9. ((b) b) 220. 0. (a(a)) 2 21. 1. (b(b) ) 2222. . (a(a) ) 2323.. (b(b) ) 2424.. ((a) a) 225. 5. (d(d)) 2 26. 6. (b(b) ) 2727. . (a(a) ) 2828.. (a(a) ) 2929.. (d(d) ) 330. 0. (b(b)) 3 31. 1. (b(b) ) 332. 2. (c(c) ) 3333.. (d(d) ) 3434.. (c(c) ) 335. 5. (b(b)) 3 36. 6. (a(a) ) 3737. . (a(a) ) 3838.. (c(c) ) 339.9. ((c) c) 440. 0. (c(c)) 4 41. 1. (a(a) ) 442. 2. (c(c) ) 4343.. (d(d) ) 444.4. ((a) a) 445. 5. (b(b)) 4

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5 51. 1. (b(b) ) 5252. . (a(a) ) 5353.. (d(d) ) 5454.. (d(d) ) 555. 5. (b(b)) 5 56. 6. (c(c) ) 5757. . (c(c) ) 5858.. (a(a) ) 5959.. ((c) c) 660. 0. (a(a)) 6 61. 1. (a(a) ) 662. 2. (b(b) ) 6363.. (c) (c) 664.4. (b(b) ) 665. 5. (a(a)) 6 66. 6. (c(c) ) 6767. . ((b) b) 6868.. (c) (c) 6969.. (d(d) ) 7070. . ((a)a) 71. 71. (c) (c) 72. 72. (c)(c)

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1.

1. Department of Transport Test (DOT)Department of Transport Test (DOT) is performed for which of the is performed for which of the following?

following? (a) Aerosols (a) Aerosols (b)

(b) Glass Glass containerscontainers (c) Capsules

(c) Capsules (d) None (d) None

2.

2. Measurement of particle size inMeasurement of particle size in pharm

pharmaceuaceutical tical aerosaerosol is ol is byby (P)

(P) Cascade Cascade impactorimpactor (Q)

(Q) Light Light scatter scatter decaydecay (R) (R) K-F K-F methodmethod (S) IR (S) IR (a) (a) P, P, Q Q (b) (b) Q, Q, RR (c) (c) R, R, S S (d) (d) P, P, SS 3.

3. Identify the correct non-flammableIdentify the correct non-flammable prope

propellantllant (a)

(a) Trichloro Trichloro monofluoro monofluoro methanemethane (b)

(b) Dichloro Dichloro monofluoro monofluoro methanemethane (c)

(c) Di Di methyl methyl etherether (d)

(d) Di Di fluoro fluoro methanemethane

4.

4. The dip tube in an aerosol container isThe dip tube in an aerosol container is made from one of the following

made from one of the following (a)

(a) Poly Poly propylenepropylene (b) Glass

(b) Glass (c) Al (c) Al (d)

(d) Stainless Stainless steelsteel

5.

5. Which one of the following device isWhich one of the following device is used to increase the efficiency of drug used to increase the efficiency of drug delivery via aerosols?

delivery via aerosols? (a)

(a) Tube Tube spacersspacers (b)

(b) Metered Metered valvesvalves (c) Actuator

(c) Actuator (d)

(d) Pressure Pressure valvevalve

6.

6. The first aerosol insecticide wasThe first aerosol insecticide was developed by

developed by (a)

(a) Good-hue Good-hue & & SullivanSullivan

(b) Good-hue (b) Good-hue (c) Sullivan (c) Sullivan (d) Franklin (d) Franklin 7.

7. The first pharmaceutical aerosol wasThe first pharmaceutical aerosol was developed in the year of

developed in the year of (a)

(a) 1945 1945 (b) 1949(b) 1949 (c)

8.

8. Which drug is formulated as firstWhich drug is formulated as first pharm

pharmaceaceuticautical aerl aerosol?osol? (a) Epinephrine (a) Epinephrine (b) Codeine (b) Codeine (c) Chloropromazine (c) Chloropromazine (d) Probenecid (d) Probenecid 9.

9. To dispense inhalation aerosols, whichTo dispense inhalation aerosols, which containers are used?

containers are used? (a)

(a) Stain Stain less less steel steel containerscontainers (b)

(b) Tin Tin plate plate containerscontainers (c)

(c) Glass Glass containerscontainers (d)

(d) Al Al containerscontainers

10.

10. The valve body /housing in a aerosolThe valve body /housing in a aerosol bottle

bottle valve valve asseassembly, mbly, is is made made fromfrom one of the following

one of the following (a) Nylon

(a) Nylon (b)

(b) Poly Poly propylenepropylene (c)

(c) Poly Poly ethyleneethylene (d)

(d) Stain Stain less less steelsteel

11.

11. The equipment listed P-T is used forThe equipment listed P-T is used for the identification of properties of the identification of properties of aerosol mentioned below. Match them. aerosol mentioned below. Match them.

1.

1. Particle Particle size size determinationdetermination (P) Pycnometer

(P) Pycnometer 2.

2. Identification Identification of pof propellantsropellants (Q)

(Q) Rotaional Rotaional viscometerviscometer 3.

3. Stability Stability of fof foamoam (R)

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4.

4. Flash Flash pointpoint (S)

(S) IR IR spectroscopyspectroscopy (T)

(T) Cascade Cascade impactionimpaction (a) (a) 1-P, 1-P, 2-Q, 2-Q, 3-R, 3-R, 4-S4-S (b) (b) 1-Q, 1-Q, 2-P, 2-P, 3-S, 3-S, 4-T4-T (c) (c) 1-T, 1-T, 2-S, 2-S, 3-Q, 3-Q, 4-R4-R (d) (d) 1-R, 1-R, 2-S, 2-S, 3-P, 3-P, 4-Q4-Q 12.

12. Match the coatings given below withMatch the coatings given below with their corresponding techniques listed their corresponding techniques listed P-T

P-T 1.

1. Compression Compression coatingcoating (P)

(P) Air Air in the in the coating coating pan pan isis replaced with Nitrogen replaced with Nitrogen 2.

2. Dip Dip coatingcoating (Q)

(Q) Application Application of cof coating oating toto conductive substrates conductive substrates 3.

3. Electrostatic Electrostatic coatingcoating (R)

(R) Acid Acid insoluble insoluble coatingcoating 4.

4. Vacuum Vacuum film film coatingcoating (S)

(S) A A tablet tablet within within a a tablettablet (T)

(T) Replaced Replaced coating coating & & dryingdrying (a) (a) 1-T, 1-T, 2-R, 2-R, 3-Q, 3-Q, 4-P4-P (b) (b) 1-Q, 1-Q, 2-R, 2-R, 3-S, 3-S, 4-T4-T (c) (c) 1-P, 1-P, 2-R, 2-R, 3-T, 3-T, 4-S4-S (d) (d) 1-R, 1-R, 2-T, 2-T, 3-P, 3-P, 4-Q4-Q 13.

13. Among the propellants used inAmong the propellants used in aerosols, one of the following is used aerosols, one of the following is used for topical pharmaceutical aerosols for topical pharmaceutical aerosols (a)

(a) Tri Tri chloro chloro monofluoro monofluoro methanemethane (b)

(b) Di Di chloro chloro difluoro difluoro methanemethane (c)

(c) Di Di chloro chloro tetrafluoro tetrafluoro ethaneethane (d) Propane

(d) Propane

14.

14. Which one of the following propellantWhich one of the following propellant is used in the aerosol for oral use

is used in the aerosol for oral use (a) Propane (a) Propane (b) Oxygen (b) Oxygen (c) Methane (c) Methane (d)

(d) Trichloro Trichloro monofluoro monofluoro methanemethane

15.

15. The identification of propellants inThe identification of propellants in pharm

pharmaceuaceutical tical aeroaerosols sols is is carrcarried ied outout by

by (P)

(P) Gas Gas chromatograchromatographyphy (R) Pycnometer

(R) Pycnometer (Q)

(Q) Tag oTag open cupen cup appap apparatusratus (S)

(S) IR IR spectrophotomspectrophotometereter (a)

(a) P,Q P,Q (b) (b) P,SP,S (c)

(c) Q, Q, R R (d) (d) R, R, SS

16.

16. Aerosol packaging container mustAerosol packaging container must resist pressure of

resist pressure of (a)

(a) 500 500 psigpsig (b) (b) 140-180 140-180 psigpsig (c) (c) 40 40 psigpsig (d) (d) 20 20 psigpsig 17.

17. Gasket is made up ofGasket is made up of (a) Bure-N

(a) Bure-N (b)

(b) Neoprene Neoprene rubberrubber (c) Both

(c) Both (d) All (d) All

18.

18. Manufacturing of aerosol involvesManufacturing of aerosol involves (a)

(a) Gas Gas fillingfilling (b)

(b) Pressure Pressure fillingfilling (c)

(c) CompresseCompressed d gas gas fillingfilling (d)

19.

19. The nature of propellant is determinedThe nature of propellant is determined by

by (a)

(a) R-F R-F methodmethod (b)

(b) Gas Gas ChromatographyChromatography (c) UV

(c) UV (d) None (d) None

20.

20. Viscosity enhancer in ophthalmicViscosity enhancer in ophthalmic prepa

preparation ration isis (a)

(a) Poly Poly vinyl vinyl alcoholalcohol (b) Povidone (b) Povidone (c) Dextran (c) Dextran (d) Macrogol (d) Macrogol

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21.

21. p pHH of human tear is of human tear is (a)

(a) 7.2 7.2 (b) (b) 88 (c)

(c) 7.6 7.6 (d) (d) 4.64.6

22.

22. Opthalmic solution is sterilized byOpthalmic solution is sterilized by (a) Autoclave

(a) Autoclave (b)

(b) Hot Hot air air ovenoven (c) Both

(c) Both

(d)

(d) Bacterial Bacterial filtersfilters

23.

23. Which of the following one is used toWhich of the following one is used to adjust the isotonicity

adjust the isotonicity (a) Dextrose

(a) Dextrose (b)

(b) Boric Boric acidacid (c) NaCl (c) NaCl (d)

KEY KEY

1

1. . ((aa) ) 22. . ((aa) ) 33.. ((aa) ) 44.. ((aa) ) 55. . ((bb)) 6

6. . ((aa) ) 77. . ((cc) ) 88.. ((aa) ) 99.. ((aa) ) 1100. . ((aa)) 1 11. 1. (c(c) ) 1212. . (a(a) ) 1313.. (d(d) ) 1414.. ((d) d) 115. 5. (b(b)) 1 16. 6. (b(b) ) 117. 7. (c(c) ) 1818.. (c) (c) 119.9. (b(b) ) 220. 0. (d(d)) 21 21. . (c(c) ) 2222. . (a(a) ) 2323.. (d(d))