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Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers

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Academic year: 2020

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Figure

Figure 1 Structure of the TLR-4/MD-2/LPSec complex.Notes: (A) Side view of the symmetrical dimer of TLR-4/MD-2/LPSec complex
Figure 2 Schematic illustration of the TLR-4 signaling pathway.Notes: TLR-4/MD-2 complex homodimerization activates the MyD88-dependent pathway and TRiF-dependent pathway
Figure 3 TLR-4 signaling induces the transformation of the nontumor microenvironment to a tumor microenvironment.fibroblasts; anti-tumor effects of CD8Notes: Lipopolysaccharide from Escherichia coli produces PAMP while the necrotic cells and other endogeno
Table 1 Summary of TLR-4 expression and its effects on various tumors

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