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FUNCTIONS INVOLVING GAMMA FUNCTION AND ORIGINATING FROM PROBLEMS OF TRAFFIC FLOW

FENG QI, JIAN CAO, AND DA-WEI NIU

Abstract. In this paper, two classes of functions, involving a parameter and the Euler gamma function, and two functions, involving the Euler gamma function, are verified to be logarithmically completely monotonic in −1

2,∞

or (0,∞) and an inequality involving the Euler gamma function, due to J. Wendel, is refined partially.

1. Introduction

The Kershaw’s inequality in [9] states that the double inequality

x+s 2

1−s

< Γ(x+ 1)

Γ(x+s) < x− 1 2 +

r

s+1 4

!1−s

(1)

holds for 0< s <1 andx≥1, where Γ denotes the classical Euler gamma function andψ= ΓΓ0, the logarithmic derivative of Γ. If takings=12 in (1), then

r

x+1 4 <

Γ(x+ 1) Γ(x+ 1/2) <

s

x+

3 −1

2 . (2)

Letsandtbe nonnegative numbers andα= min{s, t}. Forx∈(−α,∞), define

zs,t(x) =

 

 

Γ(x+t)

Γ(x+s)

1/(t−s)

−x, s6=t, eψ(x+s)x, s=t.

(3)

In order to establish the best bounds in Kershaw’s inequality (1), among other things, the papers [4, 6, 15, 19] established the following monotonicity and convexity property ofzs,t(x): The functionzs,t(x) is either convex and decreasing for|t−s|< 1 or concave and increasing for |t−s|>1. This result was further generalized in the papers [12, 13].

In [5, p. 123] and [10], while ones studied certain problems of traffic flow, the following double inequality was obtained forn∈N:

n+1 2

≤Γ

1

2

Γ(n+ 1)≤2nΓ

n+1 2

, (4)

2000Mathematics Subject Classification. Primary 33B15, 26A48, 26A51; Secondary 26D20. Key words and phrases. logarithmically completely monotonic function, gamma function, inequality.

The authors were supported in part by the Science Foundation of the Project for Fostering Innovation Talents at Universities of Henan Province, China.

(2)

which can be rearranged forn >1 as

1≤

Γ(1/2)Γ(n+ 1)

2Γ(n+ 1/2)

1/(n−1)

≤2. (5)

In [23], by using the following double inequality due to J. Wendel in [27]:

x

x+a

1−a

≤ Γ(x+a)

xaΓ(x) ≤1 (6) for 0< a <1 andx >0, inequality (4) was extended and refined as

x ≤ Γ(x+ 1)

Γ(x+ 1/2) ≤

r

x+1

2 (7)

forx >0.

It is clear that the double inequality (7) is weaker than (2).

Recall [14, 24, 28] that a functionf is said to be completely monotonic on an interval I if f has derivatives of all orders on I and 0 ≤ (−1)nf(n)(x) < for

x∈I and n≥0. The set of the completely monotonic functions on I is denoted byC[I]. The well known Bernstein’s Theorem [28, p. 161] states thatf ∈ C[(0,∞)] if and only if f(x) =R∞

0 e

−xsdµ(s), where µ is a nonnegative measure on [0,) such that the integral converges for allx >0. This expresses thatf ∈ C[(0,∞)] if and only iff is a Laplace transform of the measure µ.

Recall [2, 7, 14, 16, 17, 20, 21] also that a positive function f is called loga-rithmically completely monotonic on an intervalI iff has derivatives of all orders on I and its logarithm lnf satisfies 0 ≤ (−1)k[lnf(x)](k) < for all k

N on

I. The set of the logarithmically completely monotonic functions on I is denoted byL[I]. In [3, Theorem 1.1] and [7, 21] it is pointed out that the logarithmically completely monotonic functions on (0,∞) can be characterized as the infinitely divisible completely monotonic functions studied by Horn in [8, Theorem 4.4].

It was proved in [3, 14, 18, 20, 21, 24] that L[I] ⊂ C[I], but not conversely. Stimulated by the papers [17, 20], among other things, it was further revealed in [3] thatS \{0} ⊂ L[(0,∞)]⊂ C[(0,∞)], whereSdenotes the set of Stieltjes transforms.

Letγ= 0.57721566· · · be Euler-Mascheroni’s constant. Forx∈ −1 2,∞

, let

g(x) =

   

   

Γ(1/2)Γ(x+ 1)

2Γ(x+ 1/2)

1/(x−1)

, x6= 1,

exp

1−γ−ψ

3

2

, x= 1.

(8)

The first aim of this paper is to show the logarithmically complete monotonicity of g(x). The first main result of this paper is as follows.

Theorem 1. Let g(x) be the function defined by (8). Then g(x) ∈ L −1

2,∞

withlimx→−1

2+g(x) =∞andlimx→∞g(x) = 1.

Remark 1. From the decreasingly monotonic property ofg(x) and limx→∞g(x) = 1 in Theorem 1 andg(1) = exp

1−γ−ψ 3 2

, it is obtained that

x+1 2

≤Γ

1

2

Γ(x+ 1)≤2Γ

x+1 2

exp

(x−1)

1−γ−ψ

3

2

(3)

forx∈[1,∞). Fromg(0) = 2, limx→∞g(x) = 1 and the decreasingly monotonicity ofg(x), it is also revealed that

x+1 2

≤Γ

1

2

Γ(x+ 1)≤2xΓ

x+1 2

(10)

forx∈(0,∞).

Inequalities (9) and (10) extend (4) and (5) and the right hand side inequality of (9) refines the right hand side inequality of (4) and (5). Therefore, it can be said that Theorem 1 generalizes, extends, and refines the double inequalities (4) and (5).

By the way, numerical calculation shows

s

1 +

3 −1

2 = 1.168· · ·> 2 Γ(1/2)exp

(1−1)

1−γ−ψ

3

2

= 1.128· · ·

and

s

2 +

3 −1

2 = 1.538· · ·< 2 Γ(1/2)exp

(2−1)

1−γ−ψ

3

2

= 1.660· · ·,

hence, the right hand side inequality of (2) and the following inequality Γ(x+ 1)

Γ(x+ 1/2) ≤ 2 Γ(1/2)exp

(x−1)

1−γ−ψ

3

2

(11)

forx∈[1,∞), which is deduced from the right hand side inequality of (9), are not included each other. Similarly, it is easy to show that inequality (11) and the right hand side inequality in (7) are also not included each other inx∈[1,∞).

Forx >0 anda >0, let

ha(x) = (x+a)

1−aΓ(x+a)

xΓ(x) . (12)

The second aim of this paper is to prove the logarithmically complete monotonicity ofha(x). The second main result of this paper is as follows.

Theorem 2. Let ha(x)be the function defined by (12). Then (1) limx→0+ha(x) =

Γ(a+1)

aa andlimx→∞ha(x) = 1for any a >0,

(2) ha(x)∈ L[(0,∞)]if0< a <1,

(3) [ha(x)]−1∈ L[(0,∞)]if a >1.

Let γ = 0.57721566· · · be the Euler-Mascheroni’s constant. For x ∈ (0,∞), define

p(x) =

 

 

xx Γ(x+ 1)

1/(1−x)

, x6= 1, e−γ, x= 1.

(13)

The third aim of this paper is to present the logarithmically complete monotonicity ofp(x). The third main result of this paper is as follows.

Theorem 3. Let p(x)be the function defined by (13). Then p(x)∈ L[(0,∞)]with

(4)

Forx∈(0,∞) anda∈(0,∞), let

fa(x) =Γ(x+a)

xaΓ(x) . (14)

The fourth aim of this paper is to consider the logarithmically complete monotonic-ity offa(x). The fourth main result of this paper is as follows.

Theorem 4. Let fa(x)be the function defined by (14). Then (1) limx→∞fa(x) = 1 for any a∈(0,∞),

(2) fa(x)∈ L[(0,∞)] andlimx→0+fa(x) =∞if a >1,

(3) [fa(x)]−1∈ L[(0,)]andlimx→

0+fa(x) = 0if 0< a <1.

As a straightforward consequence of Theorem 2 and Theorem 4, the following refinement of inequality (6) is established.

Theorem 5. Let x∈(0,∞). If0< a <1, then

x

x+a

1−a

<Γ(x+a) xaΓ(x)

<

  

  

Γ(a+ 1) aa

x

x+a

1−a

≤1, 0< x≤ ap(a)

1−p(a),

1, ap(a)

1−p(a)< x <∞, (15)

wherep(x)is defined by (13). Ifa >1, the reversed inequality of (15)holds. Remark 2. The graph of the function1ap−p(a(a)), pictured by Mathematica5.2, shows that it is an increasing function from (0,∞) to (0,∞).

2. Proofs of theorems

It is well-known that, forx >0 andω >0, 1

xω = 1 Γ(ω)

Z ∞ 0

tω−1e−xtdt, (16)

and that, fork∈Nandx >0,

ψ(x) = lnx+

Z ∞ 0

1

u− 1 1−e−u

e−xudu, (17)

ψ(k)(x) = (−1)k+1

Z ∞ 0

tk 1−e−te

−xtdt. (18)

Moreover, asx→ ∞, the following asymptotic formula holds:

xb−aΓ(x+a) Γ(x+b) = 1 +

(a−b)(a+b−1)

2x +O

1

x2

, (19)

whereaandb are two constants.

It is remaked that formulas (16), (17), (18) and (19) can be found in [1, p. 257 and p. 259] and [11, 14, 16, 17, 19, 20, 21, 25, 26].

Proof of Theorem 1. Taking logarithm ofg(x) leads to

(5)

= ln Γ(x+ 1)−ln 2 x−1 −

ln Γ(x+ 1/2)−ln Γ(1/2) x−1

= ln Γ(x+ 1)−ln Γ(1 + 1) x−1 −

ln Γ(x+ 1/2)−ln Γ(1 + 1/2) x−1

= 1

x−1

Z x

1

ψ(u+ 1) du− 1

x−1

Z x

1

ψ(u+ 1/2) du

= 1

x−1

Z x

1

[ψ(u+ 1)−ψ(u+ 1/2)] du

= 1

x−1

Z x

1 Z 1

1/2

ψ0(u+t) dtdu

=

Z 1

1/2

1 x−1

Z x

1

ψ0(u+t) du

dt

=

Z 1

1/2 Z 1

0

ψ0((x−1)u+t+ 1) dudt

and, fork∈N,

(−1)k[lng(x)](k)=

Z 1

1/2 Z 1

0

uk

(−1)kψ(k+1)((x−1)u+t+ 1)

dudt≥0

by considering formula (18). This meansg(x)∈ L −1

2,∞

. By L’Hospital’s rule and formula (17), it is deduced that

lim

x→∞lng(x) = limx→∞

ψ(x+ 1)−ψ

x+1 2

= lim x→∞ln

x+ 1

x+ 1/2 + limx→∞

Z ∞ 0

1

u− 1 1−e−u

e−u−e−u/2e−xudu= 0,

which can be restated as limx→∞g(x) = 1. It is easy to see that limx→−1

2+lng(x) =∞and limx→− 1

2+g(x) =∞. The proof

of Theorem 1 is complete.

Proof of Theorem 2. Using the differences equation Γ(x+ 1) =xΓ(x) and taking limit directly gives

lim

x→0+ha(x) = limx→0

Γ(x+a+ 1) (x+a)aΓ(x+ 1) =

Γ(1 +a) aa .

Using the asymptotic expansion (19) yields

ha(x) =

Γ(x+a+ 1) (x+a)aΓ(x+ 1) =

1 + a x

−a

1 + a(a+ 1) 2x +O

1

x2

→1

asx→ ∞, which means limx→∞ha(x) = 1.

Taking logarithm of ha(x), differentiating with respect to x successively and utilizing formulas (16) and (18) leads to

lnha(x) = (1−a) ln(x+a) + ln Γ(x+a)−ln Γ(x+ 1) and, forn∈Nandn >1,

[lnha(x)](n)= (1−a)

(−1)n−1(n1)!

(x+a)n +ψ

(n−1)(x+a)

(6)

= (−1)n

(a−1)(n−1)!

(x+a)n + (−1)

nψ(n−1)(x+a)

−(−1)nψ(n−1)(x+ 1)

= (−1)n

Z ∞

0

(a−1)e−(x+a)ttn−1dt+

Z ∞

0 h

e−(x+a)t−e−(x+1)ti t n−1

1−e−tdt

= (−1)n

Z ∞

0

e−(x+a)ttn−1

1−e−t

h

(a−1) 1−e−t

+ 1−e(a−1)tidt

,(−1)n

Z ∞

0

e−(x+a)ttn−1

1−e−t r(t) dt. It is clear thatr0(t) = (a1)e−t 1eat

andr(0) = 0. Therefore, the functionr(t) is non-positive fora >1 andr(t)≥0 for 0< a <1. As a result, (−1)n[lnh

a(x)](n)≤0 fora >1 and (−1)n[lnha(x)](n)0 for 0< a <1.

By formula (17), it is easy to see that

[lnha(x)]0 = 1−a

x+a+ψ(x+a)−ψ(x+ 1) = 1−a

x+a+ ln x+a x+ 1+

Z ∞

0

1 t −

1 1−e−t

e−at−e−te−xtdt

→0

as x→ ∞. Since [lnha(x)]0 is decreasing for a >1 and increasing for 0< a <1, then [lnha(x)]0 ≥0 for a >1 and [lnha(x)]0 ≤0 for 0< a <1.

Summing up, for any positive integerk∈N, ifa >1 then (−1)k[lnh

a(x)](k)≤0, if 0< a <1 then (−1)k[lnha(x)](k)≥0. The proof of Theorem 2 is complete.

Proof of Theorem 3. From the differences equation Γ(x+ 1) = xΓ(x), it follows easily that

ψ(x+ 1)−ψ(x) = 1

x (20)

forx >0. Taking logarithm of p(x) and utilizing (20) gives

lnp(x) =xlnx−ln Γ(x+ 1) 1−x

=ln Γ(x+ 1)−ln Γ(1 + 1) x−1 −

xlnx−1 ln 1 x−1

= 1

x−1

Z x

1

ψ(u+ 1) du− 1

x−1

Z x

1

(1 + lnu) du

= 1

x−1

Z x

1

[ψ(u+ 1)−lnu] du−1

= 1

x−1

Z x

1

ψ(u)−lnu+1 u

du−1

,x1 1

Z x

1

Ψ(u) du−1

=

Z 1

0

Ψ((x−1)u+ 1) du−1.

Formulas (16) and (17) imply that

Ψ(x) =ψ(x)−lnx+ 1 x =

Z ∞ 0

eu1u u(eu1)

(7)

Sinceeu−1−u >0 for u∈(0,∞), then Ψ(x)∈ C[(0,∞)]. Therefore, fork∈N,

(−1)k[lnp(x)](k)=

Z 1

0

uk

(−1)kΨ(k)((x−1)u+ 1)

du≥0.

This meansp(x)∈ L[(0,∞)].

The L’Hospital’s rule and formulas (17) and (20) yield

lim

x→∞lnp(x) = limx→∞

xlnx−ln Γ(x+ 1)

1−x = limx→∞[ψ(x+ 1)−(1 + lnx)] = lim

x→∞

ψ(x)−lnx+1 x

−1 = lim

x→∞[ψ(x)−lnx] + limx→∞ 1

x−1 =−1. Thus, it follows easily that limx→∞p(x) = 1e.

It is clear that limx→0+lnp(x) = 0. Hence, the limit limx→0+p(x) = 1 follows.

The proof of Theorem 3 is complete.

Proof of Theorem 4. Applying (19) reveals

fa(x) =

Γ(x+a) xaΓ(x) = 1 +

a(a−1) 2x +O

1

x2

→1

asx→ ∞fora∈(0,∞). Fromfa(x) =

x1−aΓ(x+a)

Γ(x+1) , it follows that limx→0+fa(x) =

(

∞, a >1, 0, 0< a <1. Taking logarithm offa(x) and differentiating yields

lnfa(x) = ln Γ(x+a)−alnx−ln Γ(x) and, by (16) and (18) forn >1,

(−1)n[lnfa(x)](n)= (−1)n

ψ(n−1)(x+a)−ψ(n−1)(x)−a(−1)

n−1(n1)!

xn

=

Z ∞ 0

e−(x+a)t−e−xt t n−1

1−e−tdt+

Z ∞ 0

ae−xttn−1dt

=

Z ∞ 0

tn−1

1−e−t

e−at−1 +a 1−e−t

e−xtdt

,

Z ∞ 0

tn−1

1−e−ts(t)e −xtdt.

It is clear thats(0) = 0 and s0(t) =a

1−e(1−a)t

e−t. Thus, standard argument

givess(t)

(

≥0, a >1,

≤0, 0< a <1. This implies (−1) n[lnf

a(x)](n)

(

≥0, a >1,

≤0, 0< a <1. Since

[lnfa(x)]0=ψ(x+a)−ψ(x)−a

x

=

Z ∞ 0

1 t −

1 1−e−t

e−at−1e−xtdt+ ln

1 + a x

−a

x→0 as x → ∞ and the function [lnfa(x)]0 is increasing for a > 1 and decreasing for

0< a <1, then [lnfa(x)]0

(

≤0, a >1,

(8)

In a word, for k ∈N, it follows that (−1)k[lnfa(x)](k)

(

≥0, a >1,

≤0, 0< a <1. The

proof of Theorem 4 is complete.

Proof of Theorem 5. As a direct consequence of Theorem 2, a double inequality is obtained: For 0< a <1 andx >0,

x

x+a

1−a

< Γ(x+a) xaΓ(x) <

Γ(a+ 1) aa

x

x+a

1−a

. (21)

Fora >1 andx >0, the double inequality (21) is reversed.

As an easy consequence of Theorem 4, an inequality is deduced: For 0< a <1, inequality

Γ(x+a)

xaΓ(x) <1 (22) is valid inx∈(0,∞). For a >1, inequality (22) reverses.

It is a standard argument that Γ(aa+1)a

x x+a

1−a

≤1 if and only if 0< x≤ 1ap−p((aa))

for 0< a <1. The proof of Theorem 5 is complete.

References

[1] M. Abramowitz and I. A. Stegun (Eds),Handbook of Mathematical Functions with Formu-las, Graphs, and Mathematical Tables, National Bureau of Standards, Applied Mathematics Series55, 4th printing, with corrections, Washington, 1965.

[2] R. D. Atanassov and U. V. Tsoukrovski,Some properties of a class of logarithmically com-pletely monotonic functions, C. R. Acad. Bulgare Sci.41(1988), no. 2, 21–23.

[3] C. Berg,Integral representation of some functions related to the gamma function, Mediterr. J. Math.1(2004), no. 4, 433–439.

[4] Ch.-P. Chen,Monotonicity and convexity for the gamma function, J. Inequal. Pure Appl. Math.6(2005), no. 4, Art. 100. Available online athttp://jipam.vu.edu.au/article.php? sid=574.

[5] M. J. Cloud and B. C. Drachman, Inequalities with Applications to Engineering, Springer Verlag, 1998.

[6] N. Elezovi´c, C. Giordano and J. Peˇcari´c, The best bounds in Gautschi’s inequality, Math. Inequal. Appl.3(2000), 239–252.

[7] A. Z. Grinshpan and M. E. H. Ismail,Completely monotonic functions involving the gamma andq-gamma functions, Proc. Amer. Math. Soc.134(2006), 1153–1160.

[8] R. A. Horn,On infinitely divisible matrices, kernels and functions, Z. Wahrscheinlichkeits-theorie und Verw. Geb8(1967), 219–230.

[9] D. Kershaw,Some extensions of W. Gautschi’s inequalities for the gamma function, Math. Comp.41(1983), 607–611.

[10] L. Lew, J. Frauenthal and N. Keyfitz,On the average distances in a circular disc, in: Math-ematical Modeling: Classroom Notes in Applied Mathematics, Philadelphia, SIAM, 1987. [11] W. Magnus, F. Oberhettinger, and R. P. Soni,Formulas and theorems for the special

func-tions of mathematical physics, Springer, Berlin, 1966.

[12] F. Qi,A completely monotonic function involving divided differences of psi and polygamma functions and an application, submitted.

[13] F. Qi,A completely monotonic function involving divided difference of psi function and an equivalent inequality involving sum, submitted.

[14] F. Qi, Certain logarithmically N-alternating monotonic functions involving gamma and

q-gamma functions, RGMIA Res. Rep. Coll. 8 (2005), no. 3, Art. 5. Available online at http://rgmia.vu.edu.au/v8n3.html.

[15] F. Qi, The best bounds in Kershaw’s inequality and two completely monotonic functions, submitted.

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[17] F. Qi and B.-N. Guo, Complete monotonicities of functions involving the gamma and digamma functions, RGMIA Res. Rep. Coll. 7 (2004), no. 1, Art. 8, 63–72. Available on-line athttp://rgmia.vu.edu.au/v7n1.html.

[18] F. Qi and B.-N. Guo,Some classes of logarithmically completely monotonic functions involv-ing gamma function, submitted.

[19] F. Qi, B.-N. Guo, and Ch.-P. Chen,The best bounds in Gautschi-Kershaw inequalities, Math. Inequal. Appl. 9(2006), no. 3, 427–436. RGMIA Res. Rep. Coll. 8(2005), no. 2, Art. 17. Available online athttp://rgmia.vu.edu.au/v8n2.html.

[20] F. Qi, B.-N. Guo, and Ch.-P. Chen, Some completely monotonic functions involving the gamma and polygamma functions, RGMIA Res. Rep. Coll.7 (2004), no. 1, Art. 5, 31–36. Available online athttp://rgmia.vu.edu.au/v7n1.html.

[21] F. Qi, B.-N. Guo, and Ch.-P. Chen, Some completely monotonic functions involving the gamma and polygamma functions, J. Austral. Math. Soc.80(2006), 81–88.

[22] F. Qi, S.-L. Xu, and L. Debnath,A new proof of monotonicity for extended mean values, Internat. J. Math. Math. Sci.22(1999), no. 2, 415–420.

[23] J. S´andor,On certain inequalities for the Gamma function, RGMIA Res. Rep. Coll.9(2006), no. 1, Art. 11. Available online athttp://rgmia.vu.edu.au/v9n1.html.

[24] H. van Haeringen,Completely Monotonic and Related Functions, Report 93-108, Faculty of Technical Mathematics and Informatics, Delft University of Technology, Delft, The Nether-lands, 1993.

[25] Zh.-X. Wang and D.-R. Guo,Special Functions, Translated from the Chinese by D.-R. Guo and X.-J. Xia, World Scientific Publishing, Singapore, 1989.

[26] Zh.-X. Wang and D.-R. Guo, T`esh¯u H´ansh`u G`ail`un, The Series of Advanced Physics of Peking University, Peking University Press, Beijing, China, 2000. (Chinese)

[27] J. Wendel,Note on the gamma function, Amer. Math. Monthly55(1948), 563–564. [28] D. V. Widder,The Laplace Transform, Princeton University Press, Princeton, 1941.

(F. Qi)Research Institute of Mathematical Inequality Theory, Henan Polytechnic University, Jiaozuo City, Henan Province, 454010, China

E-mail address: [email protected], [email protected], [email protected], [email protected], [email protected]

URL:http://rgmia.vu.edu.au/qi.html

(J. Cao) School of Mathematics and Informatics, Henan Polytechnic University, Jiaozuo City, Henan Province, 454010, China

E-mail address:[email protected], [email protected]

(D.-W. Niu)School of Mathematics and Informatics, Henan Polytechnic University, Jiaozuo City, Henan Province, 454010, China

References

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Copper homeostasis and neurodegenerative disorders (alzheimer’s, prion, and parkinson’s diseases and amyotrophic lateral sclerosis).. Lewy bodies in alzheimer’s disease: