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Exploring protein backbone designability : the computational redesign and de novo design of helix bundle proteins

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WT00 L F V T Y L L T L L L I E A F A L L M 100% 100%

TRAD L F T L K L L D L L L I R A F D L I Q 61% 86%

FBAA L F A A L L I F L L M I K V L A F L L 34% 70%

FBNN I V A L H F I F I M K V K I Q E F A I 0% 58%

DRAA R A A L L L I V L L K I K A Q L F I K 29% 68%

DRNN I V T L L I V D I V Y W K I Y L V M I 0% 58%

RES# 53 61 64 65 68 69 71 72 75 76 87 90 91 93 94 97 100 101 104 Core RH Total RH %BRD 100 100 78 100 93 91 69 100 93 70 95 100 60 100 100 100 70 100 73

WT00 A M L C L E I L A R L I F G V I M V I 0.41 0.63

TRAD A I L A A E I L A R L I K L V I E M I 0.28 0.47

FBAA A M M A A A L A A A L L K M A L F V L 0.23 0.46

FBNN F A I A A H L A S S I L K Y A L F M L 0.27 0.50

DRAA A A Y A G E I A A A L L K Y A I E L Y 0.42 0.57

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References

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