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Genomic integration of Wnt/β catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs

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Academic year: 2020

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Figure

Fig. 1. Transcriptional program of FG and HGprogenitors correlates with differential BMPFG/fg, foregut; HG/hg, hindgut; endo, endoderm;ventx2.1respectively
Fig. 2. BMP signaling coordinates D-V patterning. (A) Experimental design. FG and HG (endoderm plus mesoderm) explants were dissected from DMSOanterior left and dorsal up) or cross-section (FG mesoderm-, HG endoderm- and HG mesoderm-enriched transcripts in
Fig. 3. Smad1 chromatin binding toBMP-regulated genes.enriched (at similar levels in the FG and HG(FG=HG; (A) Smad1ChIP-seq analysis of NF20 wholeembryos identified 7976 peaks within20 kb (upstream or downstream) of 5252genes
Fig. 4. Wnt signaling promotes the HG transcriptional program and represses the FG transcriptional program
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