• No results found

Francisella tularensis T-Cell Antigen Identification Using Humanized HLA-DR4 Transgenic Mice

N/A
N/A
Info
Download
Protected

Academic year: 2020

Share "Francisella tularensis T-Cell Antigen Identification Using Humanized HLA-DR4 Transgenic Mice"

Copied!
8
0
0

Loading.... (view fulltext now)

Download now ( 8 Page )

Full text

Figure

FIG. 2. Analysis of cell-mediated and humoral responses inducedby Rotofor fractions. (A) Rotofor fractions 5 to 10 were used to
FIG. 3. Screening of respective whole-gel elution fractions thatcontain potential T-cell antigens
FIG. 6. FopB is a T-cell reactive antigen. CD4�lation between KKF24- and mock-vaccinated CD4icant atriched from KKF24- or mock (PBS)-vaccinated HLA-DR4 tg mice andstimulated with increasing concentrations of rFopB in the presence ofhuman APCs expressing HL
FIG. 8. Immune response induced in HLA-DR4 tg mice by intra-nasal rFopB immunization. (A) Spleens were collected at 14 days

References

Download now ( PDF - 8 Page - 901.22 KB )

Related documents

HLA-B*57 Elite Suppressor and Chronic Progressor HIV-1 Isolates Replicate Vigorously and Cause CD4+ T Cell Depletion in Humanized BLT Mice

To deter- mine the in vivo contribution of viral fitness to the clinical out- come in HLA-B ⴱ 57 patients, we (i) isolated replication- competent virus from CD4 ⫹ T cells from 18

Direct Ex Vivo Analyses of HLA-DR1 Transgenic Mice Reveal an Exceptionally Broad Pattern of Immunodominance in the Primary HLA-DR1-Restricted CD4 T-Cell Response to Influenza Virus Hemagglutinin

In this study, we used HLA-DR transgenic mice to directly and comprehensively identify the specificities of hemag- glutinin (HA)-specific CD4 T cells restricted to a human class

B2 but Not B1 Cells Can Contribute to CD4+ T-Cell-Mediated Clearance of Rotavirus in SCID Mice

RV-infected SCID mice were reconstituted with unseparated peritoneal exudate cells, sorted B1 cells, or B1 cells plus CD4 ⫹ T cells from BALB/c mice.. At 2 to 3 months

Mapping myasthenia gravis–associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice

Unlike T cells from wild-type C57BL/6 mice, those from HLA-DQ8 and HLA-DR3 transgenic mice immu- nized with T-AChR recognized, primarily, two promis- cuous determinants within

Characterization of T cell phenotype and function in a double transgenic (collagen specific TCR/HLA DR1) humanized model of arthritis

In order to compare autoreactive T cell responses from the double-transgenic T cells with those from the single- transgenic DR1 mice, we immunized mice with bCII and cultured

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

(G) Mean absolute numbers (± SEM) of T eff (CD45 + CD4 + Foxp3 − cells) isolated from LN and spinal cord of DEREG mice two days after DTx or PBS treatment ( n = 11 mice per

Differences in peripheral myelin antigen-specific T cell responses and T memory subsets in atypical versus typical CIDP

Results: Atypical CIDP patients showed increased frequencies of T cell subsets, especially CD4+ effector memory T cells (TEM) and CD4+ central memory T cells (TCM) as well as a

Transgenic Mice Expressing a B Cell Growth and Differentiation Factor Gene (Interleukin 5) Develop Eosinophilia and Autoantibody Production

We stained peritoneal cells, spleen cells, and bone marrow cells from cadmium- injected 116 transgenic mice or cadmium-injected control mice with anti-Ly-1 mAb together with