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Blockade ofthe negative co stimulatory molecules PD 1 and CTLA 4 improves survival in primary and secondary fungal sepsis

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Academic year: 2020

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Figure 1 Anti-PD-1, anti-PD-L1, and anti-CTLA-4 improve survival in two-hit fungal sepsis
Figure 3 Single-hit and two-hitwas determined by immunostaining and flow cytometry. There was an increase in PD-1 expression on CD4 T cells on all three time points(days later by i.v
Figure 4 Anti-PD-1 and anti-CTLA-4 increase splenocyte cytokine production in single-hit fungal sepsis
Figure 5 Anti-PD-1 increases IFN-anti-CTLA-4 or anti-PD-1 as described in Figure 4. Following supernatant harvesting, splenocytes were treated with brefeldin for four hours andthen fixed, permeabilized and immunostained for CD4, CD8 and intracellular IFN-o
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