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Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI

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Academic year: 2020

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Figure

Fig. 1. Definitive erythroid cells arise in the PBI but not the VDA. (wild-type embryos (A-E) at 22 hpf (A), 2 dpf (B), 3 dpf (C), 4 dpf (D) and 5 dpf (E); The insets are higher magnification (20A-K) Whole-mount in situ hybridization to detect αe1-globin e
Fig. 2. VDA originated HSPCs are capable of givingrise to definitive erythroid cells once homed to thePBI
Fig. 4. Definitive myeloid cells are generated inthe VDA. (A) Lateral view of 21 hpf embryo,
Fig. 5. HSPCs are found in the VDA in 4 dpf
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