• No results found

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

N/A
N/A
Protected

Academic year: 2020

Share "URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion"

Copied!
15
0
0

Loading.... (view fulltext now)

Full text

Figure

Fig. 1 Effects of URB, autophagy inhibitor 3-MA and lysosome inhibitor CQ on CCH-induced up-regulation of proinflammatory cytokines.density analysis of COX-2 andin the hippocampus
Fig. 2 Effects of URB, autophagy inhibitor 3-MA and lysosome inhibitor CQ on CCH-induced NLRP3 inflammasome activation
Fig. 3 p62 may not be necessary for removing NLRP3 inflammasome in the process of autophagy after URB treatment.set to 1.p62/NLRP3 overlap (p62/NLRP3 overlap/mm a Representativeimmunofluorescence staining for NLRP3 and p62 in the hippocampal CA1 region
Fig. 4 The activation of CCH-induced NLRP3 inflammasome may not be restrained by controlling the autophagosome formation stage after URBtreatment
+5

References

Related documents

Severity: The behavior in question must occur more frequently in the child than in other children at the same developmental stage. Early onset: At least some of

This specific problem seeks to minimize total cost by simultaneously locating the distribution centers and designing the vehicle routes that satisfy pickup and

Aquinas says that all those things that practical reason naturally understands to be good, that is to say, all those things to which we have a

EGFR and BMP-2 positive reaction in the newborn group was mainly distributed in the proximal tubule epithelial cells, and widely distributed in the adult and old groups,

CCK8 results showed that the A2780 cells were less sensi- tive to cisplatin and increased cell viability in miR-204 inhibitor group (Fig.  4 a and Additional file  4 : Fig. S3A);

To our knowledge, this is the first description of the perceived value of a basic and clinical sciences debrief following high-fidelity, small-group simulation for first- and

3 As with our estimates of unit-output employment, the estimates of the relative price of telecommunications are weighted by the share of telecommunications output in

Methods: Chart review of patients with uncontrolled glaucoma or ocular hypertension seen at a private practice clinic (n = 55) who received bimatoprost 0.03% once daily in one eye