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Phytochemicals as novel agents for the induction of browning in white adipose tissue

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Figure

Fig. 1 Developmental origins of white, brown and beige adipocytes. Beige adipocytes are derived from mesenchymal stem cells (Myf5 − ) and are closely related to white adipocytes, while brown adipocytes are derived from Myf5 + precursor cells and are closel
Fig. 2 Model for the induction of browning by phytochemicals. Guggulsterone binds to TGR5 and increases the expression of DIO2 which in turn enhances T3 levels leading to the induction of beiging
Fig. 3 Possible TGR5-medaited effects of guggulsterone and xanthohu- xanthohu-mol. The structural similarity of guggulsterone and xanthohumol to bile acids allows them to bind to bile acid receptor TGR5 which induces cAMP mediated upregulation of DIO2

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