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Stat3 accelerates Myc induced tumor formation while reducing growth rate in a mouse model of breast cancer

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Academic year: 2020

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Figure 1: Stat3 has diverse functions in MMTV-Myc and MMTV-Neu tumors. A. Unsupervised clustering of Stat3 pathway genes in MMTV-Myc and MMTV-Neu tumors is shown
Figure 2: Physiological effect of STAT3 loss on mammary function. A. Effects of STAT3 loss on the body weight of pups nursed by different genotypes of dams including MMTV-Myc, Stat3 CKO and Myc Stat3 CKO
Figure 3: Loss of STAT3 alters tumor onset and tumor growth. A. A Kaplan-Meier plot of tumor-free survival for MMTV-Myc (n=73) and Myc Stat3 CKO (n=22) is shown
Figure 4: Incomplete excision of Stat3 in mammary tumors. A. Excision of Stat3 in tumors was tested using PCR with tail DNA of STAT3Fl/Fl mice as a control
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