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Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)- 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity

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Figure 2 shows the 1PLA, and the PHEMA-g-(PLA-DPPE) copolymer,  respectively. Compared with PHEMA (Figure 2A), the at about 1.3 and 1.5 ppm are attributable to the methyl protons of the PLA moiety located in the terminal groups and repeat units
Figure 2 1Abbreviations: H NMR spectra of (A) PHEMA, (B) PHEMA-PLA, and (C) PHEMA-PLA-DPPE, and (D) 31P NMR spectrum of (E) DPPE and PHEMA-g-(PLA-DPPE) copolymer.PHEMA, poly (2-hydroxyethyl methacrylate; PLA, poly (lactide)-1; NMR, nuclear magnetic resonance; DPPE, 2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; pNP, 4-nitrophenyl chloroformate.
Figure 3 Schematic illustration of paclitaxel encapsulation into nanoparticles with the PHEMA-g-(PLA-DPPE) copolymer by emulsion/solvent evaporation (transmission electron microscopy and dynamic light scattering characterization of empty and paclitaxel-loa
Table 1 Effects of formulation parameters on size, size distribution, loading content of paclitaxel, and encapsulation efficiency of paclitaxel-loaded PHEMA-g-(PLA-DPPE) nanoparticles
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