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Improved vaccine protection against retrovirus infection after co administration of adenoviral vectors encoding viral antigens and type I interferon subtypes

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Figure

Figure 1 FV-induced splenomegaly in adenoviral vector immunized mice. CB6F1 mice were immunized with Ad5 and Ad5F35 basedvectors encoding F-MuLV Env and Gag with or without co-administration of a specific vectored type I IFN subtype, as indicated
Figure 2 Viral loads after FV challenge infection of vaccinated micebased vectors, respectively, encoding F-MuLV Env and Gag with or without co-administration of a specific vectored type I IFN subtype, asindicated
Figure 3 Vaccine-induced F-MuLV Env-specific CD4analyzed 3 days p.c. by staining with MHC II tetramers presenting an F-MuLV Env gp70-derived epitope
Figure 4 Depletion of CD4Env and Gag with or without co-administration of vectored IFNinjected i.p
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