High Risk and Prevention

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Wednesday, April 28, 2010

Time

Topic

Presenter

Aims

09:00 - 09:15

Welcome

Dr. J.C. Acevedo & Kent C. Osborne, MD

To give the welcome and explain some

particularities of the actual meeting.

High Risk and Prevention

09:15 - 09:45

Plenary Conference:

Risk for breast cancer classification and its management in high risk women.

Moderators:

Dra. María Eugenia Bravo, Dr. Octavio Peralta

Judy Garber, MD

Director, Cancer Risk and Prevention Program; Associate Professor of Medicine, Harvard Medical School, EE.UU. To discuss the

methodology for different models of risk

assessment and which of them could be used in a particular woman.

09:45 - 10:05 Breast imaging: Magnetic resonance, mammography and ultrasound for the surveillance in high risk population women.

Emily Sedgwick, MD

Assistant Professor of Radiology at Baylor College of Medicine, Director of Breast Imaging at the Smith Breast Center, EE.UU.

To perform an up-date of the different methods utilized for the screening in high risk population.

10:05 - 10:25 Management of patients with high risk benign histology lesions.

Octavio Peralta, MD

Cirujano, Centro Integral de la Mama, Clínica Las Condes.

To discuss the

management of patients with lesions that carry on increasing risk for breast cancer. Different medical and surgical procedures

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for risk management. 10:25 - 10:45 Management of patients with

breast cancer and BRCA 1 or 2 mutations, including contra-lateral breast.

Judy Garber, MD

Director, Cancer Risk and Prevention Program; Associate Professor of Medicine, Harvard Medical School, EE.UU.

To discuss any special care for this type of patients (surgical,

medical) and at the same time the type of care of the other breast (mainly imaging and surgical or medical prevention).

10:45 - 11:05

Coffee break

All

11:05 - 11:25 Advances in breast cancer prevention.

Judy Garber, MD

Director, Cancer Risk and Prevention Program; Associate Professor of Medicine, Harvard Medical School, EE.UU.

To discuss the different strategies for breast cancer prevention.

11:25 - 11:45 Prevalence of pre-malignant and malignant lesions in specimens’ of women treated with prophylactic mastectomy.

Pablo Matamala, MD

Anátomo Patólogo, Centro Integral de la Mama, Clínica Las Condes.

To review data about histological findings in specimens from prophylactic risk

reduction mastectomies. 11:45 - 12:05 Psychological counseling for high

risk patient and her family.

Verónica Robert, Ps Psiconcóloga, Instituto Oncológico, Clínica Las Condes_. To review the psychological impact of BRCA 1 and 2 testing and carrier for the woman and her family.

Imaging of Breast Cancer

14:30 - 15:00

Plenary conference

: Future of

the breast imaging: MRI and spectroscopy, nano-technology, diffusion. Moderators: Dra. Bernardita Aguirre, Dr. Álvaro Ibarra Emily Sedgwick, MD Assistant Professor of Radiology at Baylor College of Medicine, Director of Breast Imaging at the Smith Breast Center, EE.UU. 15:00 – 15:20 Breast cancer screening: benefits Paulina Neira, MD

Radióloga, Centro

To give an analytic review of the data

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and controversies. Integral de la Mama, Clínica Las Condes

.

regarding advances in breast cancer screening, utilizing different imaging methods.

15:20 - 15:40 Imaging the tumor in women undergoing neo-adjuvant therapy.

Emily Sedgwick, MD

Assistant Professor of Radiology at Baylor College of Medicine, Director of Breast Imaging at the Smith Breast Center, EE.UU.

The use of imaging for the measurement of chemotherapy response in patients with neo-adjuvant treatment is of crucial relevance. In this topic, the aim is to discuss the usefulness of different breast imaging methods and their results.

15:40 - 16:00

Coffee break

All

16:00 - 16:20 BIRADS and pathological

correlation for patients undergoing percutaneous biopsy.

Dra. Bernardita Aguirre

Radióloga, Centro Integral de la Mama, Clínica Las Condes.

Dr. Álvaro Ibarra

Anátomo Patólogo, Centro Integral de la Mama, Clínica Las Condes

To review the experience of the Breast Imaging Department from Clínica Las Condes and results from literature.

16:20 - 17:00 Clinical cases discussion Chairs:

Dra. Bernardita Aguirre

Radióloga, Centro Integral de la Mama, Clínica Las Condes.

Dr. Juan Carlos Acevedo

Director Centro Integral de la Mama, Clínica Las Condes. Participants: Emily Sedgwick, MD Assistant Professor of Radiology at Baylor College of Medicine,

In this section, clinical cases will be presented and discussed by the panel.

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Director of Breast Imaging at the Smith Breast Center, EE.UU.

Fattaneh A. Tavassoli, MD Professor of Pathology and Obstetrics, Gynecology, and Reproductive Sciences; Director, Pathology Women's Health Program, Yale University School of Medicine, EE.UU.

Monica Morrow, MD

Chief of Breast Surgery at Memorial Sloan-Kettering Cancer Center in Manhattan, NY, EE.UU. Dr. Antonio Solá Radioncólogo Médico, Instituto Oncológico, Clínica Las Condes.

Edith Perez, MD

Professor of Medicine at Mayo Medical School, in Rochester, MN; Director of the Cancer Clinical Study Unit at the Mayo Clinic in Jacksonville, Florida, EE.UU.

17:00 - 17:30

Plenary Conference:

The role of magnetic resonance imaging in the breast cancer patient.

Moderators:

Dra. Bernardita Aguirre, Dra. Paulina Neira

Monica Morrow, MD

Chief of Breast Surgery at Memorial Sloan-Kettering Cancer Center in Manhattan, NY, EE.UU.

To review the evidence that justify or not, the use of MRI in this patient setting.

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17:30 – 19:30

Plenary Conference:

The United States -Latin America Breast Cancer Pilot Project.

Moderator:

Dr. Juan Carlos Acevedo

Jorge Gómez, MD

Director, Office of Latin American Cancer Program Development. Office of the Director, National Cancer Institute, EE.UU.

Dra. María Viniegra

Oncóloga Clínica. Jefa del Servicio de

Oncología de la Corporación Médica de San Martín, Buenos Aires, Argentina. Fernando Soares, MD, PhD Head, Dept. of Anatomic Pathology, Hospital A.C.

Camargo, Sao Paulo, Brazil.

To describe the methodology and objectives of this program, that is really important for Latin American countries.

19:30

Welcome reception

Thursday, April 29, 2010

Pathology of Breast Cancer

Time

Topic

Presenter

Aims

09:00 - 09:30

Plenary Conference:

Diagnostic and prognostic

markers for breast cancer.

Fattaneh A. Tavassoli, MD Professor of Pathology and Obstetrics, Gynecology, and Reproductive Sciences; Director, Pathology Women's Health Program, Yale University School of

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Medicine, EE.UU.

09:30 - 09:50 Minimal residual disease and

its significance for breast

cancer therapy.

Luis Cereceda, MD

Oncólogo Médico, Centro Integral de la Mama, Clínica Las Condes.

To discuss the role of minimal residual disease both in lymph nodes and bone marrow and its importance for medical treatment decisions.

09:50 - 10:10 Micro and macro environment

in breast cancer.

Fattaneh A. Tavassoli, MD Professor of Pathology and Obstetrics, Gynecology, and Reproductive Sciences; Director, Pathology Women's Health Program, Yale University School of Medicine, EE.UU.

10:10 - 10:30 Tamoxifen and endometrium.

Luis Contreras, MD

To describe the experience with.

10:30 - 11:00 Coffee break

All

11:00 - 11:20 Ductal intra-epithelial neoplasm’s:

Morphology, associated risk and molecular disturbances. Fattaneh A. Tavassoli, MD Professor of Pathology and Obstetrics, Gynecology, and Reproductive Sciences; Director, Pathology Women's Health Program, Yale University School of Medicine, EE.UU. 11:20 - 11:40 Standardization for c-erb-B-2

assessment: Immuno-histochemestry, CISH, FISH.

Luis Contreras, MD

11:40 - 12:00 Cytological assessment of surgical margins in breast pathology and sentinel lymph

Dr. Álvaro Ibarra

Anátomo Patólogo, Centro Integral de la

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node. Mama, Clínica Las Condes

12:00-12:45 Industry Symposium Roche

Innovative solutions to current and future challenges in HER2-negative breast cancer.

Edith Perez, MD

Professor of Medicine at Mayo Medical School, in Rochester, MN; Director of the Cancer Clinical Study Unit at the Mayo Clinic in Jacksonville, Florida, EE.UU. 12:45-14:00 Lunch Industry Symposium

Roche

Triple negative disease

14:30 - 15:00

Plenary Conference:

Clinical

and pathological issues in basal-like breast cancer.

Moderators: Dr. José Miguel Reyes, Dr. Luis Cereceda Fattaneh A. Tavassoli, MD Professor of Pathology and Obstetrics, Gynecology, and Reproductive Sciences; Director, Pathology Women's Health Program, Yale University School of Medicine, EE.UU.

To state the difference between triple negative and basal-like tumor. To give the pathological issues that characterized the basal-like breast cancer and correlate these issues with clinical out-come.

15:00 - 15:20 Which is the best adjuvant therapy and it sequence for triple negative disease? Edith Perez, MD Professor of Medicine at Mayo Medical School, in Rochester, MN; Director of the Cancer Clinical Study Unit at the Mayo Clinic in Jacksonville, Florida, EE.UU.

To discuss the role of adjuvant chemotherapy for this type of patients, the way it must be given and the best schedule for them.

15:20 - 15:40 Triple negative metastasic patient: How do we proceed after antracyclines and taxanes.

Dennis J. Slamon, MD, PhD

Professor of Medicine, Chief of the Division of Hematology/Oncology

To discuss the treatment modalities for these patients, mainly the role of platinum agents or other chemotherapy

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at UCLA, EE.UU. agents. 15:40 - 16:00 Coffee Break

16:00 - 16:30 Molecular therapies for triple negative disease. Edith Perez, MD Professor of Medicine at Mayo Medical School, in Rochester, MN; Director of the Cancer Clinical Study Unit at the Mayo Clinic in Jacksonville, Florida, EE.UU.

To discuss the advance of research of new molecules for the treatment of triple negative patients.

16:30 - 17:00 Plenary Conference: Are we ready for personalized adjuvant breast cancer treatment?

Oncotype-DX, Mamma-Print, and others.

Kent Osborne, MD

Director L. Duncan Cancer Center, Baylor College of Medicine, Houston, EE.UU.

To make an up-date of the data supporting the use of genetic signaling as predictive and prognostic factor. 17:15 - 18:45 Industry Symposium Glaxo

Optimizing breast cancer treatment erb B2.

Dennis J. Slamon, MD, PhD

Professor of Medicine, Chief of the Division of Hematology/Oncology at UCLA, EE.UU. 18:45 Reception Glaxo

19.00 Annual Assembly GOCCHI

Friday, April 30, 2010

Time

Topic

Speaker

Aims

09:00 - 09:30

Plenary Conference:

The role of surgery in the metastatic breast cancer: the primary breast tumor and solitary metastases.

Moderators:

Dr. Ricardo Schwartz Dr. José Miguel Reyes

Monica Morrow, MD Chief of Breast Surgery at Memorial Sloan-Kettering Cancer Center in Manhattan, NY, EE.UU.

To discuss the role of surgery in the treatment for patients with metastatic disease and with primary not treated and to discuss the role of surgery for those patients with only one or two, organ confined, lesion(s).

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09:30 - 09:50 Is there still a role for adjuvant chemotherapy in postmenopausal patients? Dennis J. Slamon, MD, PhD Professor of Medicine, Chief of the Division of Hematology/Oncology at UCLA, EE.UU.

To discuss the current role of chemotherapy in post menopausal patients, mainly referred to selection and of patients and type of therapy.

09:50 - 10:10 Is there still a role for Tamoxifeno in the adjuvant treatment of postmenopausal patients? Dr. José Miguel Reyes Oncólogo Médico, Centro Integral de la Mama, Clínica Las Condes

To discuss the new evidence about the role of TAM and AI in the

endocrine treatment of post menopausal breast cancer patients.

10:10 - 10:30 Coffee Break

10:30 - 10:50 Role of HER-2 inhibitors in the adjuvant setting. Edith Perez, MD Professor of Medicine at Mayo Medical School, in Rochester, MN; Director of the Cancer Clinical Study Unit at the Mayo Clinic in Jacksonville, Florida, EE.UU.

To review the

achievements in the field of HER-2 inhibition for the adjuvant treatment of breast cancer patients.

10:50 - 11:20

Plenary Conference:

Role of HER-2 inhibitors in the

metastatic setting.

Dennis J. Slamon, MD, PhD

Professor of Medicine, Chief of the Division of Hematology/Oncology at UCLA, EE.UU.

To highlight the role of HER-2 inhibitors in the management of HER-2 positive disease.

11:20 - 11:40 Endocrine adjuvant treatment in the pre-menopausal patient: Role of ovarian

ablation/supresion.

Dr. Carlos Regonesi

Oncólogo Médico, Centro Integral de la Mama, Clínica Las Condes.

To up-date the role of endocrine therapy for pre-menopausal patients, with special reference to the new data of meta-analysis.

11:40- 12:10 Plenary Conference: Dual inhibition: use of growth factor inhibitors and endocrine blockade: Ready for clinical use?

Kent Osborne, MD

Director L. Duncan Cancer Center, Baylor College of Medicine, Houston, EE.UU.

To up-date the research and clinical progress of dual o triple association of endocrine therapy and other molecular therapies for the treatment of breast cancer.

12:10- 12:40 Plenary Conference:

Minimizing local recurrence:

Monica Morrow, MD

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What is proven and what is not. Surgery at Memorial Sloan-Kettering Cancer Center in Manhattan, NY, EE.UU.

Oncoplastic and Breast Reconstruction Surgery

14:30 - 15:00

Plenary Conference: Breast onco-plastic surgery: Past, present and future.

Moderators:

Dr. Hernando Paredes, Dra. Nuvia Aliaga Dr. Eduardo González Cirujano Oncoplástico. Jefe Unidad de Reconstrucción Mamaria, Depto. de Mastología, Instituto Ángel H. Roffo, Buenos Aires, Argentina.

15:00 - 15:20 Immediate breast reconstruction. Dra. Nuvia Aliaga Cirujana, Centro Integral de la Mama, Clínica Las Condes_. 15:20 - 15:40 Breast reconstruction using

expanders and prosthesis.

Dr. Hernando Paredes

Cirujano, Centro Integral de la Mama, Clínica Las Condes. 15:40 – 16:00 Optimizing sequence in

radiotherapy and breast reconstruction.

Dr. Antonio Solá

Radioncólogo Médico, Instituto Oncológico, Clínica Las Condes 16:00 – 16:20 Treatment of contralateral

breast: with and without implants mastopexy.

Dr. Alberto Rancati

Jefe Servicio Cirugía Plástica y

Reconstrucción. Instituto Quirúrgico del Callao, Buenos Aires, Argentina.

16:20 - 16:40 Technical videos: • Skin sparing

mastectomy, sentinel lymph node and

Dr. Eduardo González

Cirujano Oncoplástico. Jefe Unidad de Reconstrucción

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immediate breast reconstruction with expanders. • Skin sparing mastectomy, axillary clearance and immediate reconstruction with microsurgical TRAM. • Deferred breast reconstruction with dorsal width and definitive expander. Mamaria, Depto. de Mastología, Instituto Ángel H. Roffo, Buenos Aires, Argentina.

16:40 - 17:00

Coffee break

All 17:00 - 17:20 Breast reconstruction and

lipofiling.

Dr. Alberto Rancati

17:20 - 17:40 Breast reconstruction with flaps. Dr. Hernando Paredes Cirujano, Centro Integral de la Mama, Clínica Las Condes. 17:40 - 18:00 Breast reduction and

conservative management of breast cancer.

Dr. Alberto Rancati

18:00 –18:30 Discussion and closing Adjourn