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Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2− metastatic breast cancer: a focus on ribociclib

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Figure

Figure 1 illustrated description of cell cycle progression and potential pathways for cancer therapy.Notes: += stimulates; – = inhibits.
Table 1 Overview of common FDA-approved/investigational CDK4/6 inhibitors and their potential treatment profile
Figure 2 Chemical structure of ribociclib.
Table 3 Pivotal undergoing clinical trials of ribociclib or Lee011 for the treatment of various cancers (www.clinicaltrials.gov)
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