Safety through experience

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www.memmert.com | www.atmosafe.net

Temperature control appliances for the medical industry

Clinics – Doctors‘ practices – Pharmacies

100% ATMOSAFE. MADE IN GERMANY.

Safety

through

experience

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2 2 2

Quality

creates

trust

It is our passion for details that makes our heating ovens, incubators and

waterbaths so precise and durable. The fact that all of our products are

developed and manufactured exclusively in-house has made us

tech-nology leaders in temperature control appliances. It is our hard-lined

commitment to quality that has made us a reliable partner in the medical

sector and medical research industry ever since we started out in 1947.

We know that end-to-end quality assurance is crucial when it comes to

health. Memmert has been DIN EN ISO 13 485 certified for many years.

The UF/UFplus universal oven and the IF/IFplus incubator are used to

warm non-sterile blankets and cloths. The INplus/IFplus incubator is

also applied for warming rinsing and infusion solutions. The SF/SFplus

hot air steriliser for sterilisation of medical inorganic material and the

INCOmed CO

₂

incubator for in vitro fertilisation and biosynthesis are

certified medical devices.

100% AtmoSAFE is our promise to you to guarantee a perfect

atmosphere in all our appliances. What can we do for you?

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3

M E M M E RT P R O D U C T S F O R C L I N I C S, D O C TO R S ‘ P R AC T I S E S A N D P H A R M AC I E S

Universal oven

Heating, drying, heated storage

Steriliser

Sterilising, depyrogenising

Waterbath

Tempering

Incubator

Incubating, warming and tempering

Temperature above

room temperature

Peltier cooled incubator

Warming, cooling, tempering

Compressor cooled incubator

Incubating, warming and tempering

CO

2

Incubator

Cultivation of cells and tissue

CO

2

Incubator IVF

In vitro fertilisation

Temperature

Humidity

CO

₂

and O

₂

Temperature below

room temperature

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4 W A R M I N G O F C L OT H S A N D B L A N K E T S H E AT S TO R AG E K E E P I N G K E E P I N G FA N G O W A R M

32 to 1060 litres

+30 °C to +300 °C

Natural convection or

forced air circulation

The success story of Memmert began in the year 1947, with the development of a hot air steriliser for the Red Cross. Today, Memmert heating ovens are indispensable in medical laboratories, opera-tion rooms and anaesthesiology departments in clinics.

They make a lasting impression with their aesthetics and user-friendly design coupled with unrivalled precision and reliability: corrosion-resistant, easy-to-clean stainless steel in the interior and outside, large-area all-round heating from four sides, device- specific interaction of heating and control. The UF universal oven (with extended over-temperature protection – option A6) and UFplus are suited to warm non-sterile blankets and cloths.

POSSIBLE APPLICATIONS

Warming of non-sterile cloths and blankets Keeping fango paraffi n and silicates warm for physical therapy

Heated storage of blood cultures and urine samples

UNIVERSAL OVEN U

The smaller the heating elements in an oven, the more they must be heated up to reach the required temperature in the interior. A standard ring heater with an overall heating element length of one metre will even start to glow, making a gentle and accurate adjustment con-siderably more diffi cult to achieve.

A Memmert heating oven with a volume of 749 litres is surrounded on all sides by 52 metres of heating elements. Six heating circuits are controlled separately from one another so that the required temperature is exactly attained and maintained at every point in the interior – linearly and without fl uctuations.

In a Memmert drying oven, the heating doesn’t simply switch off when the set temperature has been reached but the tem-perature is controlled permanently, gently and evenly throughout the entire chamber. The logical consequence of this unique system: Excellent values for temperature homogeneity and temperature stability.

We know how:

Precision and perfect temperature distribution

d h h

Application U:

Warming of blankets in the emergency trauma room

Innumerable clinics and hospitals use Memmert heating ovens to preheat blankets and cloths used in operating and emergency rooms. In the district hospital of Roth, Germany, there are blankets that have been preheated to 42 °C in the heating oven in order to keep patients warm before and after their operation, which minimises the risk of complications such as wound infections, cardiovascular disorders and disruptions, vascular disorders and others.

Especially in emergency trauma rooms, temperature control systems are vital when caring for seriously injured patients. Grabbing a blanket from the heating oven still is the fastest solution to avoid hypothermia or to increase the patient‘s body temperature.

em

t heating ovens to preheat blankets an strict hospital of Roth, Germany,

ing oven in order to k

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M E D I C A L D E V I C E H OT A I R S T E R I L I S AT I O N L A B O R ATO RY G L A S S I N S T R U M E N T S 5

STERILISER S

32 to 749 litres

+30 °C to +250 °C

Strict hygienic conditions prevail in laboratories, medical and veterinarian practices, clinics and hospitals as well as in pharmacies. The setpoint-dependent programme resume function Setpoint-WAIT of the Memmert hot air steriliser guarantees precise sterilisation times and the complete elimi-nation of even the most resistant microorganisms. Thus, sterilisation time does not start before the desired setpoint temperature has been reached. The Memmert SFplus hot air steriliser is a medical device used to sterilise inorganic medical material with dry heated air at atmospheric pressure.

POSSIBLE APPLICATIONS

Sterilisation of medical instruments and laboratory glass

Depyrogenisation

WATERBATH WNB/WNE/WPE

7 to 45 litres

+30 °C to +95 °C

plus boiling stage

Cooling device CDP 115

fom +10 °C as option

Size 45 with circulating pump

The Memmert waterbath is available in six model sizes and two performance classes. In addition to the Basic model for standard temperature control tasks, the Excellent version provides precise test procedures with maximum safety: The superior heating concept of Memmert ovens can also be found in the waterbaths.

The heating elements are located under deep-drawn, easy to clean ribs, where they are pro-tected from water and thus from corrosion and calcifi cation. If constant set point temperatures close to ambient temperature are needed in the waterbath, the CDP 115 Peltier cooling unit cools the medium in a precise and environmentally friendly manner to up to 10 °C with an accuracy of ±0.1 K.

Application W:

Extracting lanolin in a waterbath

Already in the 1st_{century A.D., the Greek physician Pedanios Dioskurides described a procedure}

to obtain lanolin by boiling sheep‘s wool in his famous encyclopaedia „De materia medica“. The procedure had fallen into long oblivion, but by the end of the 19th_{century lanolin had a}

comeback in pharmacology as a base for balms. Lanolin is absorbed well by the skin, has a moisturising effect and accelerates wound healing.

The pharmacy in the district hospital of Roth also manufactures balms based on lanolin following their own formula, e.g. as an emulsion for the nose that supports the healing process after a nose surgery. Lanolin is extracted at 100 °C in a Memmert waterbath that has been doing its job reliably for 30 years.

POSSIBLE APPLICATIONS

Tempering of balms and emulsions Tempering of nutrient solutions Warming of fango paraffi n and silicates for physical therapy

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6 W A R M I N G O F C L OT H S, B L A N K E T S, I N F U S I O N S O L U T I O N S I N C U BAT I N G K E E P I N G W A R M

POSSIBLE APPLICATIONS

Microbiological tests Germ count determination Incubation of cell cultures Heated storage of blood cultures, urine samples and organ cultures Warming of non-sterile cloths and blankets Tempering of rinsing and infusion solutions

INCUBATOR I

32 to 749 litres

+30 °C to +80 °C

Natural convection or

forced air circulation

The heating and temperature control in Incubator I were specifi cally designed for low temperatures from +30 °C to +80 °C. You can be certain that your chamber load will be heated most gently and without any temperature overshoots.

During the heating process, the temperature is increased within a very narrow control range and kept exactly at the set value. A pre-heating chamber heats up the supplied air, so that no temperature deviations can occur in operation. The chamber of the INplus and IFplus models can be sterilised, along with all installations, at +160 °C in a 4-hour programme. The IF incu bator (with extended overtemperature pro-tection – option A6) is used to warm non-sterile blankets and cloths. The INplus/IFplus incubator is suited for warming rinsing and infusion solutions.

Application I:

Warming of infusion solutions in the incubator

The famous English architect Sir Christopher Wren was a typical 17th_{century man. As a universal}

genius, he was not only interested in the art of construction. He built a rain gauge and, as far as it is currently known, he was the fi rst one to experiment with infusions – that is with delivering liquids and drugs to patients directly through the veins. Since syringes had not been invented yet, he used the thigh bone of a nightingale to inject wine and beer into the veins of a dog in 1656. In the 18th_{century, the invention of sugar solution represented a further milestone. But it wasn‘t until the}

19th_{and 20}th_{century, when hygiene and microbiology were further developed, that infusion therapy}

fi nally made a breakthrough.

The district clinic of Roth uses several Memmert products to keep rinsing solutions at a constant temperature of 37 °C in its operation rooms.

The INplus/IFplus Memmert incubators are classifi ed as class I medical devices according to guideline 93/42/EC and they are intended to be used as temperature control devices for rinsing and infusion solutions.

COMPRESSOR

COOLED INCUBATOR ICP

53 to 749 litres

-12 °C to +60 °C (ICP 110 - 750)

-5 °C to +60 °C (ICP 55)

If a large number of samples have to be perma-nently incubated, you can rely on the maximum utilisation of the chamber in the cooled incubator ICP. After all, of what use is a large chamber if some levels cannot be used after validation? And if rapid and precise alternation between heating up and cooling down phases in ramp operation is called for, Memmert cooled incu-bators with compressor cooling prove to be in top form. Thanks to the fi nely adjusted control technology, temperatures reach the set point precisely, without energy-intensive re-adjustment and without any tem perature fl uctuations. If you need particularly precise temperature con-trol in combination with low-noise and vibration-free operation, the Memmert Peltier-cooled incubator with its temperature range between +0 °C and +70 °C is just the right choice for you.

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7 M E D I C A L D E V I C E I N V I T R O F E RT I L I S AT I O N A N D B I O S Y N T H E S I S C U LT I VAT I N G C E L L S A N D T I S S U E

CO

₂

INCUBATOR

INCOivf

108 litres

+20 °C to +50 °C | 40 - 97 % rh

O

2

: 1 - 20 % (optional)

Module IVF with 8 separate

drawers

In conventional CO₂ incubators and in special IVF incubators, vaporisation and condensation are a major problem. For this reason, Memmert has developed an IVF module for its INCOmed CO₂ incubator.

The IVF module has 8 slide-in units and is used in a Memmert INCOmed CO₂ incubator. This ensures that the CO₂ content, O₂ content and humidity in the interior can be controlled with absolute precision. Active humidifi cation and dehumidifi ca-tion in particular, keep vaporisaca-tion to a minimum in the Memmert INCOivf, meaning that additional cultivation under oil is not required. The low air exchange with the outside ensures fast recovery times for the CO₂ content and humidity because as long as one slide-in unit is open, no other unit can be pulled out. And another invaluable advantage for users: The INCOmed CO₂ incubator into which the IVF module is integrated, also is a class IIa certifi ed medical device for in vitro fertilisation.

CO

2

INCUBATOR

INCOmed

108 | 153 | 246 litres

+20 °C to +50 °C | 88 - 97 % rh

(40 - 97 % rh humdity module

as option)

7 modules for perfect fit

Cell, tissue and bacteria cultures, as well as microorganisms, need to be protected in a con-trolled and physiologically ideal environment. The precision and reliability of the CO₂ incubator play a decisive role, because even the smallest deviation in the CO₂ atmosphere, in temperature or humidity content can have a negative infl uence on cells. For this reason, Memmert has subjected its INCOmed CO₂ incubators to a comprehensive evaluation process for their recognition as class IIa medical devices for in-vitro fertilisation and biosynthesis.

To achieve an increase in usable volume, opti-mum hygiene and short recovery times after opening the door, the optional humidity module, which is an active humidifi cation system, can be integrated. Thanks to heating from all six sides, a constant atmosphere at any place inside the chamber is guaranteed. Temperature homo-geneity is supported by an aluminium thermal conduction jacket that also serves as a heat accumulator if there is a temporary power failure.

Medical device CE 1275 IVF and biosynthesis Medical devi ce CE 1275 IVF and biosynthesis

We know how:

When it comes to cell cultivation,

active humidifi cation and dehumidifi cation is a must

The COSIR research project, with scientifi c support from the chair of bioprocess engineering at the University of Erlangen, was dedicated to one of the most important challenges for cell cultivation in laboratories: evaluating cell growth without invasive methods such as sample taking. Memmert contributed to the success of the project by providing an INCOmed CO₂ incubator.

At the beginning of the project, the incubator was evaluated and the result showed that the active humidifi cation system decreases evaporation considerably compared to incubators with passive humidifi cation. In cell cultivation in multiwell plates, evaporation and condensation cause fl uc tua-tions in the concentration, which may signifi cantly falsify test results. During the evaluation, the CO₂ incubator was used by several employees and the door was frequently opened. The excellent responsiveness of the active humidifi cation system to the continuous change of the gas mixture in the chamber humidifi ed to 95 % rh, became apparent after the INCOmed was tested for 10 days. Caused by the frequent opening of the door, the outer well rows had lost about 40 % of their humidity content, while the inner rows had only lost about 10 %. On non-workdays, a constant volume and an increase in humidity content were determined.

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Application Appliance Parameters

Warming of non-sterile blankets and cloths Universal oven UFplus +30 °C to +300 °C

Incubator IFplus +30 °C to +80 °C

Warming of rinsing and infusion solutions Incubator INplus/IFplus +30 °C to +80 °C

Sterilisation of medical instruments and laboratory glass

Steriliser SF/SFplus

(Medical device class IIa)

+30 °C to +250 °C Cultivation in vitro fertilisation and biosynthesis CO₂ Incubator INCOmed

(Medical device class IIa)

+20 °C to +50 °C, 88 to 97 % rh CO₂: 0 to 10 %

optional 0 to 20 % (CO₂ module) optional 40 to 97 % rh (humidity module) O₂: 1 to 20 % (O2 module, optional) CO2 Incubator INCOivf

(INCOmed with IVF module Medical device class IIa)

+20 °C to +50 °C, 40 to 97 % rh CO2: 0 to 10 %

optional 0 to 20 % (CO2 module) O2: 1 to 20 % optional Heated storage of blood cultures,

urine samples and organ cultures

Incubator I +30 °C to +80 °C

Warming of fango paraffi n and silicates for physical therapy

Waterbath WNB/WNE/WPE +30 °C to +95 °C

boiling stage

(with cooling unit CDP 115 from +10 °C)

Tempering of balms and emulsions Waterbath WNB/WNE/WPE +30 °C to +95 °C

boiling stage

(with cooling unit CDP 115 from +10 °C) Tempering of samples, plates, breeding

media and emulsions in the laboratory

Cooled incubator IPP 0 °C to +70 °C

Cooled incubator ICP -12 °C to +60 °C

Waterbath WNB/WNE/WPE +30 °C to +95 °C

+ boiling stage

(with cooling unit CDP 115 from +10 °C) Microbiological tests, germ count determination,

cultivation above and below room temperature

Cooled incubator ICP -12 °C to +60 °C

Cooled incubator IPP 0 °C to +70 °C

Storage cooled incubator IPS +14 °C to +45 °C

Cultivation of cells and tissue CO₂ incubator INCOmed +20 °C to +50 °C, 88 to 97 % rh

CO2: 0 to 10 %

optional 0 to 20 % (CO2 module) optional 40 to 97 % rh (humidity module)

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Some of the illustrations in this publication include special accessories

. W

e reserve the right of technical modifications

.

There is certainly a huge number of other application possibilities. We would be very pleased if you could tell us about your applications. Whatever the material, whatever the appliance and wherever you may be!

We would love to discuss with you your individual task at hand in order to fi nd a suitable solution in the context of our standard programme or our customised designs.