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The specificity of B-cell response in multiple sclerosis

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Table 1.1 MRI criteria MAGNIMS: Comparison of MRI criteria for dissemination in space (DIS) and time (DIT) (modified from Swanton, Rovira et al
Figure 1.4 CSF IgG index: Values for the quotient of IgG in CSF/IgG in serum (QIgG) are shown on the y axis and values for the quotient of albumin in CSF/albumin in serum (QAlb) are shown on the x axis
Figure 1.8 Schematic diagram of an antibody molecule and fragments: The variable (V) region of each chain contains three hypervariable regions termed complementary determining regions (CDR)s respectively CDR1, CDR2 and CDR3 that contr
Figure 1.11 Mimicking the B cell development by phage technology: The generation of antibodies by the immune system is compared with the phage display technology
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Laboratory Clinical trials (anti CD20) Antibody phage display Cloning of V genes into vector Histopathology of supplied tissues Gene Expression Immune phage-displayed libraries from B cells of MS patients’ brains Discussion

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