PhD (Submitted) MPH. Higher Diploma

BIOGRAPHICAL SKETCH

Experienced Medical Research Scientist, trained health service manager with massive public mobilization skills, vast

in many aspects of field organization, team preparation, laboratory techniques, focused situation analyst, experienced

program implementation planner, process evaluator for Quality Control and Quality Assurance. Over ten years

experience in managing financial budgets for the NIH funded research programs, trainer with vast knowledge in

national and international public health matters and target oriented team player.

NAME

ODADA SUMBA, PETER

POSITION TITLE

Senior Research Officer

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION _{(if applicable)} DEGREE MM/YY FIELD OF STUDY

Kenyatta University, Nairobi, Kenya

Case Western Reserve University, Cleveland,

Ohio, USA

University of Nairobi / Kenya Medical Training

College

PhD

(Submitted)

MPH

Higher

Diploma

05/2010

05/2004

1985-1986

Geographical medicine

Epidemiology and

international health

Parasitology / medical

entomology

Kenya Medical Training College

Diploma

1978-1981

Medical laboratory

technology

A. Personal Statement

I have worked side-by-side with many research collaborators from 1981 when I started my research career.

Our ability to recruit and retain clinically relevant study participants provides a unique and valuable human

resource by which we have been able to address many specific aims in immunology, molecular epidemiology

of malaria and childhood cancer. My mid-career educational experience, first earning my MPH from Case

Western and now the completion of my PhD degree, has furthered my ability to continue human investigations

research on infectious disease pathogenesis, and more recently in the etiology of endemic BL, severe malaria

and the impact of specific micronutrients like selenium, zinc and copper in immune development. This

ecological expertise has paved the way for me to become an independent investigator and skilled administrator

of programs. My PhD dissertation research investigated nutritional deficiencies as a risk factor for endemic BL

by reducing the ability of the body to protect itself against malaria disease and increased EBV loads paving

way for pro-oxidant by free radicals like reactive oxygen species which have been identified in many disease

pathogenesis. As a collaborator in many projects with senior colleagues from the USA and locally, I have been

mentored in a number of laboratory and field based research and publications. My lecturing career in the

universities is focused on environmental pollution, community health and molecular epidemiology.

Specific duties.



Work closely with the Centre directors, and other heads of departments and programs.



Monitor and evaluate Kenyan sites considered for work expansion



Coordinate the training of personnel in all aspects of Total Quality Management and international

quality standards.



Develop Quality Assurance Manual and quality plans for various projects.



Conducts on-site inspections of the field activities using detailed checklists to record observations



Provide technical guidance on management and execution of research projects,



coordinate and maintain all a cross studies and study-specific documentation



Collaborate with team members on the development of research protocols, manuscripts, and regulatory

submissions to Institutional Review Boards and international funding organizations.



Ensure compliance of assigned study standard operation procedures (SOPs), Good Clinical practice

(GCP), NIH and FDA policies



Coordinates site visits with inspection staff which may be assigned by various government/private

agencies to participate in the inspection process



Prepares various reports as required by Principle investigators and institutional managements



Develop SOPs and periodical quality records.



Evaluate staff competency.



Participate in quality planning and improvement.



Part time lecturer in epidemiology, environmental toxicology and clinical nutrition epidemiology at

Maseno university Public health, and Biomedical departments.

B. Positions and Honors

Positions and Employment

1981-1985

Assistant

Lecturer,

Medical

Laboratory, Nakuru MTC, Ministry of Health, Kenya

1986-2005

Senior

Laboratory

Technologist, CVBCR, KEMRI, Kenya

2004-Present

Part-time Lecturer and chief external examiner faculty of Med.laboratory. Kenya Medical

Training College, Kisumu, Kenya

2005-Present

Senior Research Officer, CVBCR, KEMRI, Kenya

2005- todate

Part-time Lecturer / Examiner Maseno University, Kenya

Other Experience and Professional Memberships

1980-1981

Chairman, Student Representative Council (SRC), Kenya

1995-1996

Chairman, Kisumu district and Nyanza National Representative, Association of Kenya Medical

Laboratory Scientific Officers

2006

Member, KEMRI Intellectual (IP) Management Committee

Member, American Association of Public Health

Member, Association of Kenya Medical Laboratory Scientific Officers

Member, American Society of Tropical Medicine and Hygiene (ASMTH)

Member, African Organization for Research and Training in Cancer (AORTIC)



African Organization for Research and Training in Cancer (AORTIC) International conference on cancer,

Dar es Salaam, Tanzania, November 2009



African Organization for Research and Training in Cancer (AORTIC) International conference on

Burkitt’s lymphoma, Kampala, Uganda, February 2008



American Society of Tropical medicine and hygiene November 2007, Philadelphia, USA



MIM conference in Yaoundé, Cameroon 12/11- 20/11/05



The 51

annual conference of the American Society of Tropical Medicine and Hygiene, Denver,

Colorado, USA 10-14, 2002



New systems for Predicting and Detecting Malaria Epidemics in the East African Highlands

inter-Countries workshop llMAL 14-16 Feb, 2002 , Kisumu, Kenya.



International association of Medical Laboratory technologists August 1986 Stockholm, Sweden,



KEMRI/ KETRI’ seminars and conferences from 1986

Honors

1986

Best Academic Student in Parasitology and Medical Entomology, MTC, Kenya

2003-2004

Graduate Student Senator, Case Western Reserve University (CWRU), USA

2004

CWRU Outstanding Student in Master of Public Health

2010 Appointed editorial committee member of international Journal of environmental science and

Public health

Publication in press: (British journal of cancer)

Manuscript: EP/2010/1098

Title: Microgeographic variations in Burkitt lymphoma incidence correlate with differences in malnutrition,

malaria and Epstein-Barr virus

PO Sumba

,

EW Kabiru

,

E Namuyenga

,

N Fiore

,

RO Otieno

, AM Moormann

, AS Orago

, PF

Rosenbaum

,

and

R Rochford

1

Kenya Medical Research Institute, Kisumu, Kenya;

Kenyatta University P.O. Box 43844-00100 Nairobi, Kenya;

Department of Zoology, Maseno University, Private Bag-40105, Maseno University, Maseno, Kenya;

Department of

Microbiology and Immunology, 750 East Adams St., SUNY Upstate Medical University, Syracuse, NY, USA 13066,

Department of Pediatrics, University of Massachusetts Medical School - Biotech II, 373 Plantation Street, Suite 318,

Worcester, MA 01605;

Kenya National AIDS Control Council, Argwings Kodhek Road. P.O. Box 61307 - 00200

Nairobi, Kenya.

Correspondence: Peter Odada Sumba, Kenya Medical Research Institute, P.O. Box 1578, Kisumu, Kenya,

E-mail;

[email protected]

C. Selected Peer-reviewed Publications

Most relevant to the current application

1. Oloo AJ, Mudegu JV, Ngare DK, Ogutu RO, Ondijo SO,

Odada PS

, Adungo NI, Githeko AK, Ekisa WS,

Mahadevan S. The effect of permethrin impregnated sisal curtains on vector density and malaria

incidence: a pilot study. East Afr Med J. 1993 Aug;70(8):475-7.

2. Githeko AK, Adungo NI, Karanja DM, Hawley WA, Vulule JM, Seroney IK, Ofulla AV, Atieli FK, Ondijo SO,

Genga IO,

Odada PK

, Situbi PA, Oloo JA. Some observations on the biting behavior of Anopheles

gambiae s.s., Anopheles arabiensis, and Anopheles funestus and their implications for malaria control.

Exp Parasitol. 1996 Apr;82(3):306-15.

3. Karanja DM, Alaii J, Abok K, Adungo NI, Githeko AK, Seroney I, Vulule JM,

Odada P

, Oloo JA.

Knowledge and attitudes to malaria control and acceptability of permethrin impregnated sisal curtains.

East Afr Med J. 1999 Jan;76(1):42-6.

4. John

CC,

Sumba PO

, Ouma JH, Nahlen BL, King CL, Kazura JW. Cytokine responses to Plasmodium

falciparum liver-stage antigen 1 vary in rainy and dry seasons in highland Kenya. Infect Immun. 2000

Sep;68(9):5198-204.

PMCID: PMC101778

.

5. John CC, Ouma JH,

Sumba PO

, Hollingdale MR, Kazura JW, King CL. Lymphocyte proliferation and

antibody responses to Plasmodium falciparum liver-stage antigen-1 in a highland area of Kenya with

seasonal variation in malaria transmission. Am J Trop Med Hyg. 2002 Apr;66(4):372-8.

6. MacNeil

A,

Sumba OP

, Lutzke ML, Moormann A, Rochford R. Activation of the Epstein-Barr virus lytic

cycle by the latex of the plant Euphorbia tirucalli. Br J Cancer. 2003 May 19;88(10):1566-9.

PMCID:

PMC2377104

.

7. John CC, Zickafoose JS,

Sumba PO

, King CL, Kazura JW. Antibodies to the Plasmodium falciparum

antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1

vary by ages of subjects and by season in a highland area of Kenya. Infect Immun. 2003

Aug;71(8):4320-5.

PMCID: PMC166050

.

8. Moormann AM, Embury PE, Opondo J,

Sumba OP

, Ouma JH, Kazura JW, John CC. Frequencies of

sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland

malaria-endemic areas of Kenya. Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4.

9. Chelimo

K,

Sumba PO

, Kazura JW, Ofula AV, John CC. Interferon-gamma responses to Plasmodium

falciparum liver-stage antigen-1 and merozoite-surface protein-1 increase with age in children in a malaria

holoendemic area of western Kenya. Malar J. 2003 Nov 5;2(1):37.

PMCID: PMC280688

.

10. Cao K, Moormann AM, Lyke KE, Masaberg C,

Sumba OP

, Doumbo OK, Koech D, Lancaster A, Nelson M,

Meyer D, Single R, Hartzman RJ, Plowe CV, Kazura J, Mann DL, Sztein MB, Thomson G,

Fernández-Viña MA. Differentiation between African populations is evidenced by the diversity of alleles and

haplotypes of HLA class I loci. Tissue Antigens. 2004 Apr;63(4):293-325.

11. John CC, O'Donnell RA,

Sumba PO

, Moormann AM, de Koning-Ward TF, King CL, Kazura JW, Crabb BS.

Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface

protein-1 (MSP-protein-1 protein-19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals

in a malaria endemic area of Africa. J Immunol. 2004 Jul 1;173(1):666-72.

12. John CC, Koech DK,

Sumba PO

, Ouma JH. Risk of Plasmodium falciparum infection during a malaria

epidemic in highland Kenya, 1997. Acta Trop. 2004 Sep;92(1):55-61.

13. John CC, Moormann AM,

Sumba PO

, Ofulla AV, Pregibon DC, Kazura JW. Gamma interferon responses

to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their

relationship to age, transmission intensity, and protection against malaria. Infect Immun. 2004

Sep;72(9):5135-42.

PMCID: PMC517451

.

14. Moormann AM, Chelimo K,

Sumba OP

, Lutzke ML, Ploutz-Snyder R, Newton D, Kazura J, Rochford R.

Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children. J Infect Dis.

2005 Apr 15;191(8):1233-8.

15. Ofulla AV, Moormann AM, Embury PE, Kazura JW,

Sumba PO

, John CC. Age-related differences in the

detection of Plasmodium falciparum infection by PCR and microscopy, in an area of Kenya with

holo-endemic malaria. Ann Trop Med Parasitol. 2005 Jun;99(4):431-5.

16. John CC, Moormann AM, Pregibon DC,

Sumba PO

, McHugh MM, Narum DL, Lanar DE, Schluchter MD,

Kazura JW. Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum

antigens and protection from infection. Am J Trop Med Hyg. 2005 Jul;73(1):222-8.

17. John CC, McHugh MM, Moormann AM,

Sumba PO

, Ofulla AV. Low prevalence of Plasmodium falciparum

infection among asymptomatic individuals in a highland area of Kenya. Trans R Soc Trop Med Hyg. 2005

Oct;99(10):780-6.

18. Moormann AM, John CC,

Sumba PO

, Tisch D, Embury P, Kazura JW. Stability of interferon-gamma and

interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related

adhesive protein in residents of a malaria holoendemic area. Am J Trop Med Hyg. 2006 Apr;74(4):585-90.

19. Githeko AK, Ayisi JM,

Odada PK

, Atieli FK, Ndenga BA, Githure JI, Yan G. Topography and malaria

transmission heterogeneity in western Kenya highlands: prospects for focal vector control. Malar J. 2006

Nov 10;5:107.

PMCID: PMC1654174

.

20. Rainey JJ, Omenah D,

Sumba PO

, Moormann AM, Rochford R, Wilson ML. Spatial clustering of endemic

Burkitt's lymphoma in high-risk regions of Kenya. Int J Cancer. 2007 Jan 1;120(1):121-7.

21. Moormann AM, Chelimo K,

Sumba PO

, Tisch DJ, Rochford R, Kazura JW. Exposure to holoendemic

malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan children.

J Infect Dis. 2007 Mar 15;195(6):799-808.

22. John CC, Tande AJ, Moormann AM,

Sumba PO

, Lanar DE, Min XM, Kazura JW. Antibodies to

pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children. J Infect Dis.

2008 Feb 15;197(4):519-26.

PMCID: PMC2607240

.

23. Rainey JJ, Rochford R,

Sumba PO

, Kowuor D, Wilson ML, Moormann AM. Family environment is

associated with endemic Burkitt lymphoma: a population-based case-control study. Am J Trop Med Hyg.

2008 Feb;78(2):338-43.

24.

Sumba PO

, Wong SL, Kanzaria HK, Johnson KA, John CC. Malaria treatment-seeking behaviour and

recovery from malaria in a highland area of Kenya. Malar J. 2008 Nov 26;7:245.

PMCID: PMC2607295

.

25. Piriou E, Kimmel R, Chelimo K, Middeldorp JM,

Odada PS

, Ploutz-Snyder R, Moormann AM, Rochford R.

Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic

malaria region of Kenya. J Med Virol. 2009 Jun;81(6):1088-93.

PMCID: PMC Journal-In Process

.

26. Dent AE, Chelimo K,

Sumba PO

, Spring MD, Crabb BS, Moormann AM, Tisch DJ, Kazura JW. Temporal

stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan adults. Malar J. 2009 Jul

16;8:162.

PMCID: PMC2719655

.

27. Moormann AM,

Sumba PO

, Tisch DJ, Embury P, King CH, Kazura JW, John CC. Stability of

interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and

thrombospondin-related adhesive protein immunodominant epitopes in a highland population from

Western Kenya. Am J Trop Med Hyg. 2009 Sep;81(3):489-95.

PMCID: PMC Journal-In Process

.

28. Ernst KC, Lindblade KA, Koech D,

Sumba PO

, Kuwuor DO, John CC, Wilson ML. Environmental,

socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands: a

case-control study. Trop Med Int Health. 2009 Oct;14(10):1258-65.

PMCID: PMC Journal-In Process

.

,D. Research Support

Ongoing Research Support

5R01

CA10267-05

Rochford

(PI)

07/01/05-04/30/10

National Cancer Institute

Effects of malaria on EBV persistence in children

Role: Co-Investigator

A multi-step model for the development of eBL was proposed in the 1980’s but little experimental data is

available to support this hypothesis. In this model, early infection of children with EBV and subsequent bouts

of malaria would suppress the EBV specific cytotoxic T cell (CTL) function and impair the host’s ability to

control the growth and expansion of the latently infected B-cells. The higher frequency of EBV-infected B cells

would increase the chance for emergence of a B-cell that had the c-myc translocation characteristics of eBL.

Therefore, this model predicts that there will be increases in the numbers of latently infected B cells in children

that are continually exposed to malaria infections. With recent development of technologies that allow

PCR-based quantitation of viral load in peripheral blood and the increased knowledge of EBV persistence in health

adults based on these methods, the time is right to revisit this long-standing hypothesis with direct

experimental data and to determine if malaria infection modulates EBV latency in children. Understanding the

persistence of the oncogenic virus EBV in this context of early primary infection and holoendemic malaria will

5R03

TW007821-02

Rochford

(PI)

04/01/08-03/31/11

Fogarty International Center

Micronutrient malnutrition and EBV persistence in children

Endemic Burkitt's lymphoma (BL) is the most common childhood cancer in low-lying humid regions of

Equatorial Africa. In Kenya, the cancer is endemic in Nyanza Province. Within Nyanza Province, we have

identified high risk and low risk clusters of BL. Two known co-factors for BL have been identified: holoendemic

malaria and EBV infection. Holoendemic malaria transmission occurs throughout Nyanza Province and

infection with EBV is not geographically restricted. This suggests that other co-factors in addition to EBV and

holoendemic malaria increase the risk for BL resulting in the high-risk clusters of BL. Several lines of evidence

suggest that another potential cofactor is micronutrient deficiency such as selenium. Selenium deficiency is

associated with several types of cancer and selenium supplementation is chemopreventative for reducing

cancer risks. We hypothesize that selenium deficiency occurs in the high BL risk area compared to the low BL

risk area and thus could be an additional co-factor increasing the risk for BL. Furthermore, we hypothesize that

selenium deficiency results in increased EBV viral load. In this proposal we will test these hypotheses by

completing the following aims: determine selenium levels in children living in regions with low and high risk for

BL and determine if reduced selenium levels correlate with elevated EBV viral load in children. We will perform

a cross-sectional analysis of children living within two high-BL risk regions and two low-BL risk regions we

identified in Nyanza Province. This proposal builds on our ongoing research projects in Kenya and the long-

standing collaboration between the two co-investigators, one at SUNY Upstate and one at the Kenya Medical

Research Institute (KEMRI). As an outcome of the proposed investigations, we expect to determine how

selenium deficiencies correlate with 2 known co-factors, EBV and malaria, in a cohort of children at risk for

developing BL. This knowledge is critical to determining the etiology of BL and ultimately, to prevent BL. This

research will be done primarily in Kisumu, Kenya at the Center for Vector Biology Research and Control,

Kenya Medical Research Institute in collaboration with P. Odada Sumba, as an extension of NIH grant

#R01CA102667. Public Health Relevance: Burkitt's lymphoma remains the most common childhood

malignancy in Equatorial Africa. We are studying what causes this cancer and why it is so common in children.

We are testing the hypothesis that essential micronutrients are deficient in children that are living in a region in

Kenya where there is a high risk for getting Burkitt's lymphoma.

Role: Co-Investigator

Completed Research Support

NIH/NIAID

5-U01-AI43906 JW

Kazura

(PI) 09/30/98-03/31/04

Immunologic Memory to Pre-erythrocytic P. falciparum

Role: Co-Investigator

NIH/NIAID

K08-AI51565

Moormann

(PI) 08/01/02-04/30/07

Immunologic Studies of Endemic Burkitt’s Lymphoma

Role: Co-investigator

FIC/NIH 1D43TW006576

CH

King

(PI)

09/05/03-03/31/08

CWRU-Kenya Infectious Diseases Research Training Program

Role: Trainee for MPH and PhD,

NIH/NIAID

1 R01-AI43906-09

JW Kazura (PI)

04/01/04-03/31/09

Human Immunity to MSP-1 in Western Kenya

Role: Co-Investigator