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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity

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Figure

Figure 1: Caffeine inhibits the ligand-induced mTOR signalling pathway in THP-1 human acute myeloid leukaemia cells
Figure 2: Effects of caffeine on TLR2-mediated biological responses of THP-1 cells. Cells were exposed for 4 h to PGN with or without 1 h pre-treatment with 1 mM caffeine before assessing the indicated biological responses: A
Figure 5: Caffeine is a weak competitive inhibitor of XOD. Kinetics of the effects of caffeine on the activity of purified bovine liver XOD were analysed as described in the Materials and methods
Figure 7: Dose-dependent effects of caffeine on SCF-induced Kit receptor-mediated intracellular pS2448 mTOR levels
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