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ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD 95 multi protein complex

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Academic year: 2020

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Figure

Figure 1. Acutely isolated neurones retain functional synaptic boutons. (a) Whole-cell currents were recorded in the acutely isolated neocortical layer II/III pyramidal neurone simultaneously with staining with synaptic vesicular marker FM1–43
Figure 2. fluorescent and gradient contrast imaging (superimposed). Note the decrease in the FM1–43 fluorescence after Stimulation of individual neocortical synapses elicits glutamateric and purinergic synaptic currents
Figure 3. potentials of Inactivation of single-bouton NMDA EPSCs after series of purinergic responses
Figure 4. Interaction between NMDA and P2X receptors requires PSD-95 complex. Inactivation of NMDA EPSC after series of purinergic responses was measured in the pyramidal neurones of neocortical slice of wild-type and PSD-95 mutant mice
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