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Business Description and Key Statistics

Price, Moving Averages & Volume

Website: ICB Industry: ICB Subsector: Address: Employees: Current YTY % Chg Revenue LFY (M)

Operating EPS LFY Market Value (M)

Shares Outstanding LFY (000) Book Value Per Share

EBITDA Margin % Net Margin %

Long-Term Debt / Capital % Dividends and Yield TTM Payout Ratio TTM %

60-Day Average Volume (000) 52-Week High & Low

Price / 52-Week High & Low Syncona is a closed-ended investment company. Co.'s investment

objective is to achieve long-term capital appreciation from its investments. Co. invests in life science businesses (including private and quoted companies) and single or multi-asset projects (Life Science Investments). Co. targets an annualized return across its net assets of 15% per annum over the long term. Co. also holds a portion of its assets as a capital pool to ensure it has capital available to make future Life Science Investments.

Financials

Closed End Investments www.synconaltd.com

Arnold House;St. Julian Avenue St. Peter Port GBR -167 -0.29 1,769 663,666 1.88 116.90 117.0 0.0 0.00 - 0.00% 0.0 723 278.50 - 180.00 0.96 - 1.48 175.1 175.1 188.6 188.6 202.2 202.2 215.7 215.7 229.2 229.2 242.8 242.8 256.3 256.3 269.9 269.9 283.4 283.4 Q1' 20 Q2 Q3 Q4

Volume (000)

0 0 1,132 1,132 2,263 2,263 3,395 3,395 4,527 4,527 Q1' 20 Q2 Q3 Q4 Mean (705.29) Syncona Ltd is currently trading at 266.50 which is 3.0% above its 50 day moving average price of 258.82 and 10.9% above its 200 day moving average price of 240.38.

SYNC:LN is currently 4.3% below its 52-week high price of 278.50 and is 48.1% above its 52-week low price of 180.00. Over the past 52-weeks, SYNC:LN is up 22.5% while on a calendar year-to-date basis it is up 2.1%.

The Relative Strength Index (RSI) indicator for SYNC:LN is currently 57.05. An RSI value of 70 and above is considered overbought and 30 and below oversold.

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Price Performance, Technical Indicators & Risk Metrics

5-Year Price Performance vs. FTSE 350

Difference

Price Performance % Change vs FTSE 350

1-Day % 1-Week % 4-Week % 52-Week % Quarter-to-Date % Year-to-Date % Last Month % Last Quarter % Last Calendar Year %

Technical Indicators 50-Day Average Price Price / 50-Day Average 200-Day Average Price Price / 200-Day Average RSI - Relative Strength Index

Risk Metrics Price Volatility Sharpe Ratio Sortino Ratio -0.37 0.38 7.89 22.53 2.11 2.11 6.53 4.82 19.18 -2.39 0.94 -5.47 35.04 -7.73 16.43 -5.81 -2.85 5.01 258.82 1.03 240.38 1.11 57.05 5.62 0.21 0.45

Syncona Ltd Current: 2.08 CAGR: 15.8%

FTSE 350 Index Current: 1.07 CAGR: 1.4%

0.8 0.8 0.9 0.9 1.0 1.0 1.2 1.2 1.3 1.3 1.4 1.4 1.6 1.6 1.7 1.7 1.8 1.8 1.9 1.9 2.1 2.1 2.2 2.2 2.3 2.3 2016 2017 2018 2019 2020 2021 SYNC:LN ^NMX:LN

Over the past five years, Syncona Ltd's stock price is up 107.8% which is 100.6% above the FTSE 350 Index performance of 7.1% over the same period. Syncona Ltd's cumulative annualized growth rate (CAGR) over the five year period has been 15.8% while that of the FTSE 350 Index has been 1.4%.

Over the past year, Syncona Ltd's stock price performance of 22.5% has outperformed that of the FTSE 350 Index by 35.0%. On a year-to-date basis, Syncona Ltd's stock price performance of 2.1% has outperformed the FTSE 350 Index by 16.4%.

Over the past week, Syncona Ltd's stock price performance of 0.4% has outperformed that of the FTSE 350 Index by 0.9%.

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Growth and Profitability Metrics

Historical Growth 3-Year 5-Year 10-Year

Revenues %

Revenues Per Share % EBITDA %

Operating EPS % Free Cash Flow % Cash from Operations % Book Value %

Profitability

5-Year 10-Year Current Average Average Gross Margin % EBITDA Margin % Pre-Tax Margin % Net Margin % Return on Equity % Return on Capital % Return on Assets % -100.0 22.8 11.4 -100.0 19.5 8.5 116.9 116.9 117.0 -13.8 -14.0 -13.7 94.4 94.4

Current: -167.30 Median: 85.94 High: 439.12 Low: -227.95 CAGR:

Revenue (M)

-261.3 -261.3 16.6 16.6 294.6 294.6 572.5 572.5 2016 2017 2018 2019 2020 5.0 85.9 196.4 439.1 -167.3

Current: -0.29 Median: 0.26 High: 0.61 Low: -0.38 CAGR: -0.1%

EPS Diluted

-0.43 -0.43 -0.02 -0.02 0.40 0.40 0.81 0.81 2016 2017 2018 2019 2020 0.26 0.61 -0.29

Current: 117.04 Median: 91.14 High: 280.94 Low: 78.57 CAGR: 15.6%

Net Profit Margin %

68.5 68.5 142.7 142.7 216.9 216.9 291.1 291.1 2016 2017 2018 2019 2020 Mean (113.28)

Current: -13.80 Median: 20.40 High: 35.00 Low: -13.80 CAGR: -7.1%

Return on Equity %

-16.2 -16.2 1.7 1.7 19.5 19.5 37.4 37.4 2016 2017 2018 2019 2020 Mean (16.60) Syncona Ltd's cumulative annualized revenue growth rate over the charted period is . This compares to revenue growth of % last fiscal year and cumulatative annualized growth of % over the past 3 years.

Syncona Ltd's cumulative annualized EPS growth rate over the charted period is -0.1%. This compares to EPS growth of % last fiscal year and cumulatative annualized growth of % over the past 3 years.

Syncona Ltd's net profit margin last fiscal year of 117.0% is 3.8% above the period's mean net margin of 113.3%. During the charted period, the observed net profit margin high and low were 280.9% and 78.6% respectively.

Syncona Ltd's return on equity of -13.8% is 30.4% below the period's mean return on equity of 16.6%. During the charted period, the observed ROE high and low were 35.0% and -13.8% respectively.

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Valuation Metrics

5-Year 10-Year

Current Median Median

Price / EPS TTM Price / Sales

Price / Operating Cash Flow Price / Book Value

5-Year 10-Year

Current Median Median

Earnings Yield % Free Cash Flow Yield % Dividend Yield %

Enterprise Value / EBITDA 99.9 0.0 1.4 7.3 1.2 9.0 1.1 -12.29 0.00 50.0 1.14 12.4 12.7

Current: 99.90 Median: 8.61 High: 99.90 Low: 3.62 CAGR: 157.9%

Price / EPS TTM

-1.2 -1.2 34.1 34.1 69.4 69.4 104.7 104.7 2016 2017 2018 2019 2020 Median (8.61)

Current: 0.01 Median: 7.31 High: 49.90 Low: 0.01 CAGR: -79.6%

Price / Sales

-2.48 -2.48 15.81 15.81 34.10 34.10 52.39 52.39 2016 2017 2018 2019 2020 Median (7.31)

Current: 1.42 Median: 1.18 High: 1.81 Low: 0.87 CAGR: 6.9%

Price / Book Value

0.8 0.8 1.2 1.2 1.5 1.5 1.9 1.9 2016 2017 2018 2019 2020 Median (1.18) Syncona Ltd is trading at 99.90 times its EPS generated during the latest fiscal year. This multiple is above the historically observed median of 8.61, while high and low observations have been 99.90 and 3.62.

Syncona Ltd is trading at a Price to Sales ratio of 0.01 based on sales generated during the latest fiscal year. This ratio is below the historically observed median ratio of 7.31, while high and low observations have been 49.90 and 0.01.

Syncona Ltd is trading at a Price to Book ratio of 1.42 based on book value at the latest fiscal year end. This ratio is above the historically observed median of 1.18, while high and low

observations have been 1.81 and 0.87.

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Dividends Data

Dividend Growth and Yield

Dividends Per Share TTM 0.00 Payout Ratio TTM % 0.00% Dividend Yield TTM % 0.00%

Rate Ex Date Record Date Payment Date Currency Note

0.023 20-06-2019 21-06-2019 29-07-2019 GBP FINAL GROSS

0.023 21-06-2018 22-06-2018 30-07-2018 GBP FINAL GROSS

0.023 20-07-2017 21-07-2017 23-08-2017 GBP FINAL GROSS

0.022 14-07-2016 15-07-2016 19-08-2016 GBP DIVIDEND IN SHARES WITH CASH ALTERNATIVE 0.021 16-07-2015 17-07-2015 19-08-2015 GBP DIVIDEND IN SHARES WITH CASH ALTERNATIVE

Current: 0.00 Median: 0.02 High: 0.05 Low: 0.00 CAGR: 0.0%

Dividends Per Share TTM

-0.003 -0.003 0.007 0.007 0.016 0.016 0.025 0.025 0.034 0.034 0.043 0.043 0.053 0.053 2016 2017 2018 2019 2020

Current: 0.00 Median: 1.14 High: 1.88 Low: 0.00 CAGR: 0.0%

Dividend Yield TTM %

-0.09 -0.09 0.25 0.25 0.60 0.60 0.94 0.94 1.28 1.28 1.63 1.63 1.97 1.97 2016 2017 2018 2019 2020 Syncona Ltd's trailing 12-month dividend per share is 0.00 and its dividend has grown at a cumulative annualized rate of 0.0% over the charted period. This compares to dividend growth of -100.00% over the past year and cumulative annualized growth of -100.00% over the past 3 years.

Syncona Ltd's current dividend yield is 0.00% based on trailing 12 month dividends. The current yield is below the historically observed median of 1.14% and, over the charted time period, the observed high yield has been 1.88% and the observed low yield has been 0.00%.

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Subsector Peer Comparisons

Market Value (M)

Revenue LFY (M)

Price / EPS TTM

Price / Book Value

EPS 5-Year Growth Rate %

Revenue 5-Year Growth Rate %

0 0 4,746 4,746 9,492 9,492 14,239 14,239 18,985 18,985 Scottish Mortgage Investment Trust Plc

Pershing Square Holdings Ltd Peer Group Average F&C Investment Trust PLC RIT Capital Partners PLC Monks Investment Trust Plc Polar Capital Technology Trust Plc (The) Alliance Trust PLC (The) Fidelity Special Values Plc International Public Partnerships Ltd 3I Infrastructure PLC Syncona Ltd 18,165 5,667 4,569 4,249 3,153 3,049 3,048 2,952 2,760 2,748 2,706 1,769 -470 -470 121 121 712 712 1,303 1,303 1,895 1,895 Pershing Square Holdings Ltd

F&C Investment Trust PLC Alliance Trust PLC (The) Peer Group Average Polar Capital Technology Trust Plc (The) 3I Infrastructure PLC International Public Partnerships Ltd Monks Investment Trust Plc RIT Capital Partners PLC

Syncona Ltd 1,787 715 582 427 384 254 174 76 42 -167 0.0 0.0 26.2 26.2 52.4 52.4 78.5 78.5 104.7 104.7 Syncona Ltd

Peer Group Average International Public Partnerships Ltd 3I Infrastructure PLC RIT Capital Partners PLC Polar Capital Technology Trust Plc (The) Alliance Trust PLC (The) Pershing Square Holdings Ltd

99.9 22.4 18.6 11.5 9.1 8.4 5.4 3.6 0.0 0.0 0.4 0.4 0.8 0.8 1.2 1.2 1.6 1.6 Monks Investment Trust Plc

Syncona Ltd

Pershing Square Holdings Ltd Polar Capital Technology Trust Plc (The) Peer Group Average 3I Infrastructure PLC International Public Partnerships Ltd F&C Investment Trust PLC Alliance Trust PLC (The) RIT Capital Partners PLC

1.6 1.4 1.3 1.3 1.2 1.2 1.1 1.0 1.0 1.0 -158.1 -158.1 145.2 145.2 448.5 448.5 751.8 751.8 1,055.0 1,055.0 Polar Capital Technology Trust Plc (The)

Peer Group Average Alliance Trust PLC (The) Pershing Square Holdings Ltd RIT Capital Partners PLC International Public Partnerships Ltd 3I Infrastructure PLC 999.9 176.1 32.6 16.1 11.2 -0.7 -2.7 -7.6 -7.6 0.2 0.2 8.0 8.0 15.8 15.8 23.6 23.6 F&C Investment Trust PLC

Alliance Trust PLC (The) Pershing Square Holdings Ltd Polar Capital Technology Trust Plc (The) International Public Partnerships Ltd Peer Group Average RIT Capital Partners PLC 3I Infrastructure PLC 22.2 16.3 14.5 14.4 14.2 12.9 12.3 -3.6

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Abbreviations: CAGR EBIT EBITDA LFY M LON Definitions: Market Value Revenue

Revenue Per Share Operating EPS LFY

60-Day Average Volume (000) Price 52-Week High

Price 52-Week Low Price / 52-Week High Price / 52-Week Low 50-Day Average Price 200-Day Average Price Price / 50-Day Average Price Price / 200-Day Average Price Relative Strength Index

Price Volatility Sharpe Ratio Sortino Ratio

Dividends Per Share TTM Payout Ratio

Dividend Yield TTM % EBITDA

Free Cash Flow Book Value

Book Value Per Share Gross Margin % EBITDA Margin % Pre-Tax Margin % Net Profit Margin % Return on Equity % Return on Capital % Return on Assets % Price / EPS TTM Price / Sales Price / Book Value Free Cash Flow Yield % Enterprise Value Enterprise Value / Sales Enterprise Value / EBITDA Enterprise Value / EBIT

Enterprise Value / Free Cash Flow Russell 1000 Index

- Cumulative annual growth rate. - Earnings before interest and taxes.

- Earnings before interest, taxes, depreciation & amortization. - Last fiscal year

- Million

- London Stock Exchange

- Weekly Price times latest Shares Outstanding times any applicable ADR factor. - Sum of the last four quarters of Revenues.

- Sum of the last four quarters of Total Revenue divided by Weighted Average Shares Outstanding. - EPS excluding non-recurring, non-operating items, fiscal year aligned TTM value.

- The average of the last 60 daily volume values in thousands of shares. - The high closing price from the last 52 weeks of daily closing prices.

- The low closing price from the last 52 weeks of daily closing prices.

- Latest price divided by the high price from the past 52 weeks of daily closing prices. - Latest price divided by the low price from the past 52 weeks of daily closing prices.

- Mean of last 50 daily closing prices. - Mean of last 200 daily closing prices.

- Latest closing price divided by mean of last 50 daily closing prices, as a percentage. - Latest closing price divided by mean of last 200 daily closing prices, as a percentage.

- Relative Strength Index or RSI measures the magnitude of gains over a given time period against the magnitude of losses over that period. The equation is RSI = 100 - 100 / (1 + RS) where RS = (total gains / n) / (total losses / n) and n = number of RSI periods. In this item, 14 days is used and one year of daily prices are considered. A value of 30 or below may imply oversold and 70 or above may imply overbought.

- The standard deviation of the last 20 days of daily closing prices.

- The 5 year average of the excess monthly return over the risk - free rate(1 - month T - bill) over the 5 year standard deviation of the same series.

- The same calculation as the Sharpe Ratio but with positive excess returns set to zero for the standard deviation denominator, so only negative volatility weighs in.

- Sum of the last four quarters of Dividends Per Share. - Dividends Per Share TTM divided by Operating EPS TTM.

- Sum of the last four quarter of Dividends Per Share divided by Weekly Price. - Sum of the last four quarters of EBITDA (Operating Income + Depreciation & Amortization).

- Sum of the last four quarters Net Cash from Operations minus Capital Expenditures (Purchase of Property, Plant & Equipment), from the Cash Flow Statement.

- Total Common Equity last quarter divided by Shares Outstanding last quarter.

- Total Common Equity last quarter divided by Shares Outstanding last quarter.

- Sum of the last four quarters Gross Profit divided by the sum of the last four quarters Revenues. - Sum of the last four quarters EBITDA divided by the sum of the last four quarters Revenues.

- Sum of the last four quarters of Earnings Before Taxes divided by sum of the last four quarters Revenues. - Sum of the last four quarters of Operating EPS divided by sum of the last four quarters Revenues Per Share. - Sum of the last four quarters of Operating EPS divided by the average of the last four quarters Book Value.

- Sum of the last four quarters of Operating EPS divided by the average of the last four quarters Total Capital Per Share. - Sum of the last four quarters of Operating EPS divided by the average of the last four quarters Total Assets Per Share. - Weekly Price divided by the sum of the last four quarters of Operating EPS (capped at 99.9).

- Weekly Price divided by Revenues Per Share TTM.

- Weekly Price divided by Book Value Per Share last quarter. Book Value Per Share is Total Common Equity last quarter divided by Shares Outstanding last quarter (capped at 49.9).

- Free Cash Flow Per Share TTM divided by Weekly Price.

- Market Value plus Total Debt last year plus Preferred Equity last year minus Cash & Cash Equivalents last year. - Enterprise Value divided by the sum of the last four quarters of Revenue.

- Enterprise Value divided by EBITDA TTM.

- Enterprise Value divided by trailing four quarters of Operating Income.

- Enterprise Value divided by the sum of the last four quarters of Free Cash Flow. - The largest 1,000 stocks by market cap, the index comprehensively covers the US large cap universe. EPS 5-Year Growth Rate % is capped at 999.9%.

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References

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