Personality disorders อ.พญ.ส ก ญญา ร กษ ขจ ก ล ภาคว ชาจ ตเวชศาสตร คณะแพทยศาสตร มหาว ทยาล ยนเรศวร
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(3) Personality. disorder. ◦ Behavior - deviate from cultural standards ◦ Rigidly ◦ Lead to unhappiness and impairment ◦ Ego –syntonic ◦ Alloplastic.
(4) Enduring subjective experiences Onset in adolescence or early adulthood Stable through time Refuse psychiatric help Deny their problems . . Personality trait.
(5) . PD is a common and chronic disorder. . Generally considered to have poor prognosis. ½ of all psychiatric pts have PD.
(6) Classification Cluster A. ◦ schizotypal, schizoid, and paranoid ◦ odd, aloof features Cluster B. ◦ narcissistic, borderline, antisocial, and histrionic ◦ dramatic, impulsive, unstable and erratic features.
(7) Cluster C. ◦ obsessive-compulsive, dependent, and avoidant ◦ anxious and fearful features . Many persons exhibit traits that are not limited to a single personality disorder “multiple personality”.
(8) Etiology.
(9) Genetic Factors Cluster A ◦ Associated with schizophrenia ◦ Schizotypal > paranoid or schizoid.
(10) Genetic Factors . Cluster B ◦ Antisocial PD - alcohol , suicide ◦ Borderline PD – depression , mood disorders ◦ Histrionic PD - somatization disorder (Briquet’s syndrome).
(11) Genetic Factors Cluster C ◦ Avoidant - often have high anxiety levels. ◦ OCPD - show some signs asso with depression Shortened REM latency abnormal dexamethasone-suppression test (DST).
(12) Biological Factors . Hormones ◦ impulsive traits high levels of testosterone, 17-estradiol, and estrone..
(13) . Platelet Monoamine Oxidase ◦ Social activity ◦ Low platelet MAO levels noted in some pts with schizotypal disorders..
(14) . Smooth Pursuit Eye Movements ◦ saccadic (i.e., jumpy) Introverted low self-esteem tend to withdraw schizotypal PD.
(15) . Electrophysiology ◦ Changes in EEG antisocial and borderline types slow-wave activity.
(16) . NTs หลายตัวมีผลต่ อพฤติกรรมและบุคลิกภาพ ◦ Endorphine สูงขึน้ เฉื่อยชา ◦ Dopamine , Serotonin mood. . 5-HIAA are low ◦ Attempt suicide ◦ Impulsive ◦ Aggressive.
(17) Psychoanalytic Factors Sigmund. Freud :. ◦ personality traits are related to a fixation at one psychosexual stage of development..
(18) . Oral character ◦ Passive ◦ Dependent. . Anal character ◦ Stubborn ◦ parsimonious ◦ highly conscientious.
(19) Defense mechanism . Master feelings ◦ ◦ ◦ ◦ ◦ ◦. Anxiety Depression Anger Shame Guilt Others.
(20) Social factors เด็กเกิดการเรียนรู้ บ่ มเพาะนิสัยใจคอ บุคลิกภาพ Environment Culture Social.
(21) Cluster A.
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(23) Paranoid personality disorder.
(24) Epidemiology . 0.5 to 2.5 % ในประชากรทั่วไป. มักจะไม่ ยอมรั บการรั กษา . Men > women.
(25) During interview มีทท ี ่ าวางตัวเป็ นทางการ ไม่ ค่อยผ่ อนคลาย สายตาสอดส่ าย มองไปรอบๆ ไม่ แสดงอารมณ์ ขัน มีทท ี ่ าจริงจัง พูดตรงไปตรงมา และมีเหตุผล . Defense : projection. Disdain = ดูถกู.
(26) Diagnosis . Excessive suspiciousness. . Distrust of others expressed. . Interpret actions of others as deliberately demeaning, malevolent, threatening, exploiting, or deceiving..
(27) Diagnosis . Begins by early adulthood. . Often pathologically jealous. . Externalize their own emotions. Idea. of reference.
(28) . In social situations ◦ may appear business-like and efficient ◦ but they often generate fear or conflict in others..
(29) Course and Prognosis Some – lifelong Harbinger of schizophrenia Lifelong problems working and living with others Occupational and marital problems are common. .
(30) Differential Diagnosis Delusional disorder Schizophrenia Borderline PD Antisocial PD Schizoid PD .
(31) Treatment . Psychotherapy ◦ treatment of choice ◦ T. should be straightforward ◦ T. must remember that trust and toleration of intimacy are troubled areas for patients with this disorder..
(32) . Individual psychotherapy not overly warm style from therapists.. . Usually do not do well in group psychotherapy.
(33) Pharmacotherapy . Dealing with agitation and anxiety. . Antianxiety agent – diazepam. . Antipsychotic - haloperidol.
(34) Schizoid Personality Disorder.
(35) Epidemiology . Prevalence 7.5%. . Men > women.
(36) Clinical Features Cold and aloof Quiet , distant, seclusive, and unsociable. Solitary interests Success at noncompetitive lonely jobs .
(37) . Inability to express anger directly.. . Nonhuman interests ◦ mathematics ◦ astronomy, ◦ very attached to animals.. . Require no personal involvement.. . Have a normal capacity to recognize reality.
(38) . They are the last to be aware of changes in popular fashion.. . Men may not marry because they are unable to achieve intimacy. . Women may passively agree to marry an aggressive man who wants the marriage..
(39) Differential Diagnosis Schizotypal PD Schizophrenia Paranoid PD Obsessive –compulsive disorder Delusional disorder Avoidant PD .
(40) Course and Prognosis Onset - usually occurs in early childhood Disorder is long lasting, but not necessarily lifelong The proportion of patients who incur schizophrenia is unknown. .
(41) Treatment . Psychotherapy ◦ similar to paranoid personality disorder..
(42) Pharmacotherapy ◦ ◦ ◦ ◦. small dosages Antipsychotics - agitation SSRIs - less sensitive to rejection BZDs - diminish interpersonal anxiety.
(43) Schizotypal Personality Disorder.
(44) Epidemiology 3% of the population Sex ratio is unknown Biological relatives of patients with schizophrenia .
(45) Clinical Features Strikingly odd or strange Magical & disturbed thinking and communicating Peculiar notions Ideas of reference (not delusion) Body illusions Derealization .
(46) Frank thought disorder is absent Speech . ◦ distinctive or peculiar ◦ have meaning only to them ◦ often needs interpretation. . Believe that they have other special powers of thought and insight..
(47) . Poor interpersonal relationships and may act inappropriately, isolated and have few friends.. . Under stress decompensate and have psychotic symptoms (usually brief).
(48) Differential Diagnosis Schizophrenia Schizoid PD Avoidant PD Paranoid PD Borderline PD .
(49) Course and Prognosis . Long -term study 10 % committed suicide.. . May be prodromal of schizophrenia. . Some, maintain a stable schizotypal personality.
(50) Treatment . Psychotherapy ◦ No differ from schizoid ◦ T. must not be judgmental about their beliefs or activities..
(51) Pharmacotherapy ◦ Antipsychotic ◦ Antidepressants.
(52) Cluster B.
(53) Antisocial Personality Disorder.
(54) Epidemiology . Men > women. . Onset is before the age of 15. . In prison, prevalence may be 75%. . Familial pattern is present.
(55) Clinical Features . Often seem to be normal and even charming and ingratiating. . Impress opposite-sex clinicians with the colorful, seductive aspects of their personalities. . Same -sex clinicians may regard them as manipulative and demanding.
(56) . Their histories beginning in childhood ◦ ◦ ◦ ◦ ◦ ◦ ◦. Lying Truancy Running away from home Thefts Fights Substance abuse Illegal activities.
(57) . They are extremely manipulative. . Promiscuity, spousal abuse, child abuse, and drunk driving. . Lack of remorse for these actions. . Appear to lack a conscience..
(58) Diagnosis ปี ผู้ป่วยต้ องมีอายุอย่ างน้ อย 18 ปี . Onset เกิดก่ อนอายุ 15.
(59) Differential Diagnosis Schizophrenia Substance abuse Mental retardation Mania .
(60) Course and Prognosis Unremitting course Prognosis varies Some - symptoms decrease as persons grow older. .
(61) Treatment . Psychotherapy ◦ If pts are placed in hospital. . Pharmacotherapy ◦ Deal with anxiety, rage, and depression ◦ Control impulsive behavior.
(62) Borderline Personality Disorder.
(63) Epidemiology Present in about 1-2 % Women > men . . First -degree relatives - Increased prevalence of ◦ major depressive disorder ◦ alcohol use disorders ◦ substance abuse.
(64) Clinical Features Almost always appear to be in a state of crisis Unstable affect, mood, behavior Can have short-lived psychotic episodes Behavior - highly unpredictable Object relations All good – all bad .
(65) . Repetitive self-destructive acts ◦ เรียกร้ องความสนใจ ◦ ประชด ◦ แสดงความโกรธ.
(66) . Cannot tolerate being alone - accept a stranger as a friend or behave promiscuously. . Fear of abandonment. . Feelings of emptiness. . Identity diffusion.
(67) Differential Diagnosis Schizophrenia Schizotypal personality disorder Paranoid personality disorder .
(68) Course and Prognosis Fairly stable High incidence of MDD Occupational problems Marital problems .
(69) Treatment . Psychotherapy : treatment of choice ◦ Is difficult ◦ Because pts regress easily act out their impulses show labile or fixed negative or positive transferences alternately love and hate T..
(70) . Behavior therapy ◦ control patients' impulses and angry outbursts ◦ reduce their sensitivity to criticism and rejection ◦ Social skills training - improve interpersonal behavior..
(71) Pharmacotherapy ◦ Antipsychotics : anger, hostility, and brief psychotic episodes ◦ Antidepressants : depressed mood ◦ Benzodiazepines : anxiety and depression.
(72) Histrionic Personality Disorder.
(73) Epidemiology Prevalence : 2-3% Women > men Association with somatization disorder and alcohol use disorders. .
(74) Clinical Features . High degree of attention-seeking behavior Tend to exaggerate their thoughts and feelings Make everything sound more important than it really is. Seductive behavior Need for reassurance is endless.
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(76) Differential diagnosis Borderline PD Somatization disorder Dissociative disorder .
(77) Course and Prognosis . Some - symptoms decrease as persons grow older.
(78) Treatment . Psychotherapy ◦ Probably treatment of choice ◦ Pt are often unaware of their own real feelings ◦ Clarification of their inner feelings is an important.
(79) Pharmacotherapy ◦ adjunctive when symptoms are targeted.
(80) Narcissistic Personality Disorder.
(81) Epidemiology . Prevalence- < 1 % in general population..
(82) Clinical Features Grandiose sense of self-importance Consider themselves special and expect special treatment They handle criticism poorly May become enraged when someone dares to criticize them .
(83) Relationships are fragile Interpersonal exploitiveness is commonplace cannot show empathy Feign sympathy only to achieve their own selfish ends Fragile self-esteem susceptible to depression. .
(84) Differential diagnosis Borderline PD Antisocial PD Histrionic PD .
(85) Course and Prognosis Chronic and difficult to treat Aging is handled poorly They may be more vulnerable, therefore, to midlife crises than are other groups. .
(86) Treatment . Psychotherapy ◦ Difficult ◦ May be group therapy. . Pharmacotherapy ◦ Lithium - mood swings ◦ Antidepressants - depression.
(87) Cluster C.
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(89) Avoidant Personality Disorder.
(90) Epidemiology Common Prevalence 1 -10% .
(91) Clinical Features Hypersensitivity to rejection Hypervigilant about rejection Timidity Show a lack of self-confidence Low self esteem .
(92) . Misinterpret other persons' comments ◦ derogatory or ridiculing. . Refusal of any requests ◦ leads them to withdraw from others and to feel hurt.
(93) Course and Prognosis . Able to function in a protected env.. . Some marry, have children, and live their lives surrounded only by family members. . If support system fail depression, anxiety, and anger.
(94) Differential diagnosis Schizoid PD Histrionic , Borderline PD .
(95) Treatment . Psychotherapy ◦ T. Encourages pt to move out into the world ◦ Caution ; failure can reinforce a patient's already poor self-esteem. ◦ Group therapy ◦ Assertiveness training.
(96) . Pharmacotherapy ◦ Used to manage anxiety and depression ◦ Serotonergic : help rejection sensitivity..
(97) Dependent Personality Disorder.
(98) Epidemiology Women >men Persons with chronic physical illness in childhood may be most susceptible to the disorder. .
(99) Clinical Features pervasive pattern of dependent submissive behavior cannot make decisions without an excessive amount of advice and reassurance from others .
(100) avoid positions of responsibility become anxious if asked to assume a leadership role do not like to be alone, they seek out others on whom they can depend .
(101) Differential diagnosis Histrionic , Borderline PD Schizophrenia , Schizotypal PD Agoraphobia .
(102) Course and Prognosis . Occupational functioning tends to be impaired ◦ disorder cannot act independently and without close supervision. Social relationships are limited to those on whom they can depend Risk - major depressive disorder .
(103) Treatment . Psychotherapy ◦ Treatment often successful. ◦ Insight-oriented therapies ◦ Behavioral therapy.
(104) . Pharmacotherapy ◦ Used to deal with specific symptoms.
(105) Obsessive-Compulsive Personality Disorder.
(106) Epidemiology Men > women Diagnosed most often in oldest children. Often have backgrounds - harsh discipline . . Freud: ◦ difficulties in the anal stage.
(107) Clinical Features Preoccupied with rule Regulations Orderliness Neatness Details Perfection Lack of flexibility .
(108) They are formal and serious Often lack a sense of humor . . Defense mechanism ◦ rationalization, isolation, intellectualization, ◦ reaction formation , undoing.
(109) Course and Prognosis Variable and unpredictable. May develop OCD Depressive disorders, especially those of late onset, are common. .
(110) Treatment . Psychotherapy ◦ Unlike other PD – OCPD are often aware of their suffering, and they seek treatment on their own ◦ Group therapy ◦ Behavior therapy ◦ Individual psychotherapies.
(111) . Pharmacotherapy ◦ Clonazepam – severe ◦ Clomipramine ◦ Serotonergic agents.
(112) Thank you for your attention !.
(113)
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