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Pharmacokinetics and comparative effects of telithromycin (HMR 3647) and clarithromycin on the oropharyngeal and intestinal microflora

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Table I.Pharmacokinetic parameters of telithromycin and clarithromycin in plasma and saliva Telithromycin (n10)Clarithromycin (n10) day 1day 10day 1day 10 Parameterplasmasalivaplasmasalivaplasmasalivaplasmasaliva C max (mg/L) mean2.353.052.033.062.982.38
Figure 2. Impact of (a) telithromycin and (b) clarithromycin administration on the intestinal aerobic microflora of 10 subjects
Figure 3 shows the effect of telithromycin and clarithro- clarithro-mycin on the anaerobic intestinal microflora
Figure 3. Impact of (a) telithromycin and (b) clarithromycin administration on the intestinal anaerobic microflora of 10 subjects
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