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T-Cell Responses before and after the Fifth Consecutive Acellular Pertussis Vaccination in 4-Year-Old Dutch Children

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FIG 1 Different groups of children were used in this study: wP-primed and aP-primed children at 2, 3, 4, and 11 months of age received a booster at 4 years ofage with either a low-dose or a high-dose vaccine
FIG 2 Concentrations of Th1 (TNF-� and IFN-�), Th2 (IL-5), Th17 (IL-17), and IL-10 cytokines in supernatants of PBMCs of wP- (gray bars) and aP-primed(white bars) children specific for the pertussis proteins PT, FHA, and Prn
FIG 3 Numbers of IFN-after booster vaccination in wP- (circles) and aP-primed (triangles) childrenspecific for the pertussis proteins PT, FHA, and Prn
FIG 5 PT- (A) and Prn-specific (B) plasma IgE values in wP- (circles) andaP-primed (triangles) children prebooster (n � 46 and n � 32, respectively)and at 28 days after a low-dose booster (gray symbols) (n � 46 and n � 16,respectively) or a high-dose booste

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