Our lymphocytes: Basic building blocks of the cellular immune response and more!

Integrative Biological Newsletter Issue 2 / 2021

Our lymphocytes:

Basic building blocks of the cellular immune response and more!

INUSpheresis® Center Alpstein Clinic

Appenzell-Switzerland

Dear patients and friends of the Alpstein Clinic,

During summer all we want to think about is vacation, sun, beach and relaxation. But unfortunately the general mood in society is still clouded by „COVID 19 issues“ and controversies. We have been working diligently at the Alpstein Clinic – we have managed our increasing flow of patients and have also been happy about the expanding number of international guests. However, international travel is still difficult.

The time was also amply used for conceptual improvement of our diagnostic and therapeutic services with the perennial goal of achieving the fastest path to improvement and cure of chronic conditions for our patients.

This newsletter gives you an insight into our optimized environmental analytics and the treatment options that can be derived from them.

On behalf of the Alpstein Clinic team,

Dr. R. Oettmeier Chief physician

Med. Pract. F. Oberle Leading physician

Andreas Scherrer CEO

THIS NEWSLETTER INCLUDES:

Lymphocytes in the body

Toxin diagnostics in immune cells: a long desired innovation becomes reality Pollutant analysis at the Alpstein Clinic Ways to reduce pollutant loads and

case studies

News from the Alpstein Clinic

Figure: Lymphatic, © Alpstein Clinic As glypho

spha te Cd, Hg, Lindan, D

TT

Many billions of lymph cells flow through our body. Of these, the smallest part is in the blood, as the following figure shows. Most immune cells cavort in the more than 600 lymph nodes, the spleen, the bone marrow, the intestinal wall, the thymus and the spleen.

About 700,000 lymph cells pass through one lymph node alone every day. They have multiple functions and are core elements of the defense against disease-promoting viruses (including COVID-19), specific bacteria (e.g. tuberculosis, Lyme bacteria and syphilis), fungi and finally cancer cells.

A distinction is made between so-called B and T lymphocytes. The first group forms the antibodies (=immunoglobulins) and

the T lymphocytes matured in the thymus are trained for immune management for specific defensive tasks. For example, there are the T helper cells, the regulatory T cells, the natural

„killer cells“ and finally the so-called memory lymphocytes (= T memory cells).

Lymphocytes, along with granulocytes (bacteria defense) and macrophages (phagocytes), are the only cells that are motile and penetrate all body parts, tissues, organs and even the brain.

The most important groups of lymphatic cells are shown in the following figure from our book

„Say YES to Life“ (Reuter/ Oettemeier/ Vizkelety)

Figure: Distribution of lymphocytes in the body

© Nach Stoll, Z. Onkologie 36 / 2014

Figure: The types of lymph cells

© Buch Sag JA zum Leben von Reuter/ Oettmeier/ Vizkelety Lymphozyte transfer

though the blood per day 500 x 10⁹

blood 10 x 10⁹ Spleen

70 x 10⁹

Bone marrow 50 x 10⁹

Thymus 50 x 10⁹

Intestine 50 x 10⁹

Lung 30 x 10⁹ Other tissues

40 x 10⁹

Lymph nodes 190 x 10⁹

Basic knowledge

Lymphocytes in the body

Helper-T-cell

Active T-cell B-cell

Killer cell

Suppressor cell Phagocytic cell

We have known for a long time how significant environmental toxins are as disease-causing factors. Since 1950, about 450,000 (Source: KMT Continuing Education Course - Presentation) new chemical substances have entered the environment and their significance for our health, respectively triggering all possible chronic disease and cancer is still in its infancy.

Nevertheless, research can now clearly name many substances with regard to their toxicological profile (poisoning).

The American platform „ATSDR“ provides extensive information on toxins (poisons) in correlation with diseases and publishes every 2 years a ranking of the most toxic substances.

Basic Knowledge

Most toxic substances

2019 Rank Substance Name Total Points CAS RN

1 Arsenic 1676 7440-38-2

2 Lead 1531 7439-92-1

3 Mercury 1458 7439-97-6

4 Vinyl Chloride 1356 75-01-4

5 Polychlorinated Biphenyls 1345 136-36-3

6 Benzene 1327 71-43-2

7 Cadmium 1318 7440-43-9

8 Benzo(a)pyrene 1307 50-32-8

9 Polycyclic Aromatic Hydrocarbons 1278 130498-29-2

10 Benzo(b)fluoranthene 1253 205-99-2

THE ATSDR 2019 SUBSTANCE PRIORITY LIST

Figure: Extract from the ATSDR priority list.

© atsdr.cdc.gov

The amount of potentially toxic (poisonous) substances has increased dramatically!

Toxin diagnostics in immune cells

Pollutant analysis at the Alpstein Clinic

Toxin diagnostics in immune cells: a long desired innovation becomes reality.

Despite a variety of efforts by holistic physicians, the acceptance in the medical profession of toxins in the body as a major cause of disease

has so far fallen short of expectations.

The insufficient scientific acceptance of hair mineral analysis, SO-Check hand scan (oligoscan) or chelate mobilization test is also responsible for this.

Figure: Pollutant analysis in the lymphocytes

© Alpstein Clinic

However, thanks to intensive research in the field of analytics, it has now been possible to determine the content of toxic substances of all kinds in lymphocytes with a precision of

98 (!) percent. This is an „intracellular, electrical capacitive measurement“. Until now, this was only common in wet chemistry. However, microchip technology has created considerable potential in fluid measurement, so that the system of measuring fluid substances, taking into account the metal-binding proteins, can also be applied to all kinds of other

chemical substances.(proteins, metals, organic substances) could be transferred (1-4).

The following example shows a measurement result of the „Top 24 Environmental Toxins“

from the area of heavy metals and organic environmental toxins. It should be noted here that the concentration of the pollutants is in the range „nmol/l“, which corresponds exactly to the concentration ranges of hormones and messenger substances in the nervous system.

Ideally, the measured values should be below 10 nmol/l, which is rather rare. Frequently, the toxins are found in the borderline range (= borderline), which in total can also

attain medical significance. The laboratory cooperating with us offers a range of about 900 contaminants from 21 substance classes.

Adhesives (13)

Antibiotics (48)

Bactericidal (12)

Chemicals (88) Chemotherapeutics

(46)

Dyes (64)

Detergent (34)

Food toxins (71) Fungal toxins

(38)

Heavy metals (54)

Herbicides (37)

Insecticides (49) Medication

(103)

Microplastics (47)

Pesticides (40)

Plasticizer (softener) (45)

Radioactive substances (16)

Silicones (27)

Dental materials (51)

Vaccination supplements (42) Volatile organic

compounds (7)

Table: Analysis profile of lymphocyte enrichments (number of substances in parentheses)

© Alpstein Clinic

Based on the mentioned ATSDR ranking list, we offer analysis of the most important 27 (Basic) and 53 (Advanced) at the Alpstein Clinic.

One of our patients with chronic weakness, skin eczema, recurrent infections, depression, and hormonal imbalances has approximately 300 pollutants in her lymphocyte measurements.

What surprised us was that it showed only 1 percent with normal values, whereas more than 50 percent showed borderline or elevated levels of toxins.

n many cases, in addition to occupational and private exposure to sources of toxins, such high levels of pollutants are also due to genetic

or epigenetic weaknesses of the excretory enzymes. This can also be analyzed very well in the meantine.

Test Module Very High

>500 High

>300 Borderline

>100 Tolerable

<100 Normal

< 10

54 Metals 0 15 19 20 0

37 Herbicides 0 8 17 12 0

49 Insecticides 0 13 19 16 1

20 Microplastics 0 7 9 4 0

40 Pesticides 0 8 14 17 1

44 Microplastics 0 8 18 17 1

23 Dental materials 0 8 6 9 0

TOTAL 267 0 67 (25%) 102 (38%) 95 (36%) 3 (1%)

Table: Distribution of pollutant analysis in a patient, © Alpstein Clinic

Example of a decrease in the activity of detoxification enzymes phase 2 (mitochondria), © Alpstein Clinic

TOTAL ENZYMATIC ACTIVITY: REDUCED

Gene Variant Genotype Expected

enzymatic activity Estimated remaining enzymatic activity (%)

CYP2E1 Dral SNP / rs72559710 homozygous wild type normal PHASE I

CYP2E1 Pstl SNP / rs3813867 homozygous wild type normal 100%

EPHX1 Tyr113His heterozygous mutation decreases PHASE II

31,25 %

EPHX1 His139Arg heterozygous mutation decreases

GSTM1 Present / Absent absent zero

GSTT1 Present / Absent present decreases

GSTP1 lle105Val homozygous mutation strongly decreased

GSTP1 Ala114Val homozygous mutation strongly decreased

SOD2 Val16Ala homozygous mutation strongly decreased

COMT Val158Met homozygous wild type normal

Analysis Average length (base pairs) Interpretation

Telomere

length 6323 excellent

Case studies

Reduction of pollutant loads

All patients listed below and in detail suffered from chronic complaints, which persisted despite extensive classical as well as naturopathic treatment efforts.

Only the pollutant analysis in the lymphocytes

opened the chance for a causal, profound treatment. Here are a few patient examples that make us sit up and take notice.

CASE 1: Woman, 59 years

• Diagnoses: Polymyalgia rheumatica, Hashimoto‘s thyroiditis

• In the „top 24 pollutant analysis“ are increased nickel, aluminum, antimony, fumigadine, organic mercury, PBB and other 5 toxic substances in the borderline range

CASE 2: Woman, 40 years

• Diagnoses: anxiety syndrome, reactive depression, chronic fatigue, chronic infections, multiple food allergies.

• In the „top 24 pollutant analysis“, cadmium, antimony, and formaldehyde are elevated and another 5 toxic substances are in the borderline range

CASE 3: Man, 45 years

• Diagnoses: chronic irritable bowel, irritable bladder, prostatitis, recurrent infections.

• The „top 2 pollutant analysis“ shows increased levels of aflatoxin B, formaldehyde, chlorotoluene, fumigadine, mercury, cadmium, nickel, lead, nitrosamine, triclosan and 5 other toxic substances in the borderline range.

CASE 4: Woman, 52 years

• Diagnoses: general cognitive performance decline, propensity to chronic viral and fungal infections, multiple chemical sensitivity syndrome.

• The „top 24 pollutant analysis“ includes formaldehyde, chlorotoluene, diesel exhaust, organic mercury, nickel, chromium VI, lindane, glyphosate and another 10 toxic substances in the borderline range

CASE 5: Woman, 39 years

• Diagnoses: multiple allergies (food, grasses, animal dander)

• In the „top 24 pollutant analysis“, aflatoxin B, CTABr, diesel exhaust, organic mercury, antimony, glyphosate as well as phthalates and a further 9 toxic substances in the borderline range

CASE 6: Woman, 22 years

• Diagnoses: chronic sinusitis with obstructed nasal breathing, fatigue, multiple food allergies.

• In the „top 24 pollutant analysis“, formaldehyde, chlorotoluenes, organic mercury, aluminum, lindane, benzoquinones, BPP, phthalates as well as triclosan and a further 4 toxic substances in the borderline range

CASE 7: Woman, 64 years

• Diagnoses: Breast cancer (early stage)

• In the „top 24 pollutant analysis“, aflatoxin B, CTABr, lindane, phthalates as well as triclosan and further 12 toxic substances in the borderline range

CASE 8: Woman, 55 years

• Diagnoses: multiple thromboses, embolism and brain sleep, polycythemia, fatigue syndrome, hormonal disorders and nail mycosis.

• The „top 24 pollutant analysis“ includes formaldehyde, cadmium, aluminum, PBB, eiphenols, phthalates, nitrosamine, triclosan and 13 other toxic substances in the borderline range.

... and many more.

Of course, the best diagnostics are of little use if effective, adequate therapies are not also available.

In this area the concept of the Alpstein Clinic has very extensive possibilities:

Two case studies underline the efficiency of our approach:

1

2

3

4

5

www.alpstein-clinic.ch/therapiekonzept/inuspherese/ )

CASE 1: Man, 72 years

• Diagnoses: early stage Alzheimer‘s disease, hypertension, condition after glaucoma surgery.

• Execution of 2 INUSpheresis, post-treatment with herbal detoxification agents.

• In the „top 24 contaminant analysis“ of the INUSpherese® filtrate are increased.

• A few weeks after the therapy, the patient reports that he is largely free of symptoms and that his vitality has improved significantly.

CASE 2: Woman, 67 years

• Diagnoses: chronic, therapy-resistant right thoracic spine pain, hormonal disorders, exhaustion.

• The „top 24 pollutant analysis“ of the INUSpherese®

filtrate shows an increase in aluminum, lead, fumigadine, fungisterol A, lindane, nitrosamine and 8 other organic substances in the borderline range.

• The patient reports freedom from back pain just a few days after the second treatment, which continues for the next few months. She feels like „at least 10 years younger“. The chronic back pain was obviously caused by a chronic, toxic liver load with radiation in the reflex zone of the lower thoracic spine.

News from the Alpstein Clinic

INUSpherese

: Highly innovative Blood plasma purification to strengthen the

immune defense and self-healing

The Alpstein Clinic offers this procedure as a certified INUS partner in Switzerland and has access to the worldwide wealth of experience in apheresis therapy through its close cooperation with the INUS center in Cham (Germany).

The Alpstein Clinic welcomes Dr.med. Frank Kaiser, who together with Dr. Frank Oberle will take care of the INUSpheresis®.

He also has extensive experience in the field of „interventional pain therapy“ and „manual therapy“. We are happy to have him on our team.

We wish you and your families a wonderful fall season, good health and happiness!

Literature and links:

(1) https://www.mdpi.com/1424-8220/21/6/1929

(2) https://pubs.rsc.org/en/content/articlelanding/2021/TC/D0TC05719C

(3) https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/syst.202000063

ZÜRICH ZURICH

BERNBERNE

GENFGENEVE

BASEL BASEL

LUZERN LUCERNE

CHURCHUR

LUGANO LUGANO

GAIS / APPENZELL GAIS / APPENZELL FRANKFURT/MAIN

FRANKFURT/MAIN

MAILAND MILANO

MÜNCHEN MUNICH

G A I S / S W I T Z E R L A N D

SCHWEIZ SWIT ZERL AND

LOCATION AND ARRIVAL:

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Dorfplatz 5 CH-9056 Gais/Schweiz

Tel: +41 71 791 81 00 [email protected] www.alpstein-clinic.ch