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Control of lens development by Lhx2 regulated neuroretinal FGFs

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Figure

Fig. 1. Loss of function of Lhx2 in neuroretina led to microphthalmia and lens development defects
Fig. 2. Fgf3Data were analyzed using unpaired two-tailedexpression levels in, Fgf9 and Fgf15 were downregulated in Chx10-Cre;Lhx2lox/lox retinas
Fig. 3. Cre-mediated induction of Fgf10 expression in Chx10-Cre;Lhx2lox/lox;pMes-Fgf10 retinas restored expression of FGF-regulated genes in lens.(A-D) Mouse genetics and anticipated retinal-derived FGF expression for (A) Chx10-Cre;Lhx2lox/+, (B) Chx10-Cre
Fig. 5. Chx10-Cre;Lhx2for Prox1 (green) and Aquaporin-0 (red) expression in lenses at E11.5 (A-D), E12.5 (E-H), E13.5 (I-L), E15.5 (M-P), E18.5 (Q-T) and P0.5 (U-X) ofLhx2lox/lox;pMes-Fgf10 animals expressed the mature lens fiber marker Aquaporin-0
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