1)
1) commitmentcommitment toto γδγδ -- gamma,gamma, deltadelta -- lineagelineage of of TT cellscells occursoccurs inin whichwhich thethe following
following developmentaldevelopmental stage:stage: -- DNDN
-CD4+CD8+ -CD4+CD8+ DPDP -- SPSP
-- maturemature naïvenaïve TT cellcell 2)
2) WhatWhat thethe differencedifference betweenbetween memorymemory && naïvenaïve cells:cells:
-- MemoryMemory cellscells recirculaterecirculate betweenbetween bloodblood && tissues,tissues, naïvenaïve betweenbetween bloodblood && L.N.L.N. 3)
3) IL-2IL-2 activates:activates:
-- JAK5,JAK5, STAT1STAT1 && STAT3STAT3 4)
4) All All of of thethe followingfollowing willwill notnot protectprotect fromfrom tumor tumor formationformation exceptexcept (i.e.(i.e. whichwhich one
one protectsprotects fromfrom tumors)tumors) a)
a) CD8CD8 cellscells reactingreacting toto tumor tumor antigensantigens [all
[all other other answersanswers werewere thethe evasionevasion mechanisms]mechanisms]
-- IntroductionIntroduction of of tetanustetanus toxoidtoxoid isis classifiedclassified asas ……… immunityimmunity a)
a) arartitifificiaciall activeactive b)
b) artificialartificial passivepassive c)
c) naturalnatural activeactive d)
d) naturalnatural passivepassive e)
e) acquiredacquired activeactive 5)
5) WhichWhich of of thethe followingfollowing isis mismatchedmismatched a
a) ) IILL--110 0 : : mamasstt cellscells b)
b) IL-6IL-6 :: Th2Th2 cellscells 6)
6) TheThe mechanismmechanism thatthat breakdownbreakdown peripheralperipheral tolerance:tolerance: -- Molecular Molecular mimicry.mimicry.
7)
7) Autoan Autoantiboditibodieses bindbind aa glycoproteinglycoprotein inin thethe basementbasement membranemembrane of of thethe lunglung && glomeruli
glomeruli thisthis occur occur in:in: -- Goodpasture'sGoodpasture's syndromesyndrome 8)
8) C-ANCA:C-ANCA:
-- Wegener'sWegener's granulomatosisgranulomatosis 9)
-- OncogeneOncogene 10)
10) DiGeorgeDiGeorge syndromesyndrome is:is: -- MonogenicMonogenic
1
11)1) TheThe diseasedisease thatthat defectdefect inin actinactin cytoskeleton:cytoskeleton: -- Wiskott-AldrichWiskott-Aldrich syndromesyndrome
12)
12) PromotePromote transcriptiontranscription of of HIVHIV genes:genes: -- NF-Kb,NF-Kb, NF-ATNF-AT
13-13- notnot aa causecause of of secondarysecondary immuneimmune deficiencydeficiency :: -- GeneticGenetic mutationmutation
14)
14) thethe bestbest placeplace wewe cancan getget stemstem cellcell fromfrom it:it: -- CordCord bloodblood
15)
15) thethe mostmost challengechallenge atat BoneBone marrowmarrow transplantation:transplantation: -- graftgraft versusversus hosthost reactionreaction –GVHD- –GVHD- ..
16)
16) CyclosporineCyclosporine && tacrolimustacrolimus are:are: -- T-cellT-cell signalingsignaling BlockadeBlockade
17)
17) Carcino-embryonicCarcino-embryonic antigensantigens are:are: -- DevelopmentalDevelopmental proteinsproteins
18)
18) TToo increaseincrease thethe half-lifehalf-life of of INF-aINF-a wewe add:add: -- PolyethylenePolyethylene glycolglycol (PEG)(PEG)
19-19- InterlukeinInterlukein 1212 isis secretedsecreted fromfrom whichwhich cell:cell: -- MacrophageMacrophage
20-20- complementcomplement defectsdefects leadlead toto :: -
- neineisssserieria a infinfectectioionsns
21-21- WhatWhat isis thethe tissuetissue typingtyping techniquetechnique thatthat isis usedused toto detectdetect antibodiesantibodies againstagainst donor
donor HHLLA A :: -
- HLHLA A ccrroosss s mamattcchihingng
23-23- cyclosporinecyclosporine actsacts onon ::
24-24- TheThe disadventagedisadventage of of usingusing musemuse monoclonalmonoclonal antibodiesantibodies :: -
- tthhe e huhumaman n bbooddy y pprrododuuccees s aanntiti moumouse se antantiboibodiediess 25
25 -- thethe diseasedisease thatthat improvesimproves duringduring pregnancypregnancy isis :: -- MultipleMultiple sclerosissclerosis
-- SLESLE 26
26 -- thethe tendencytendency toto havehave IgEIgE responseresponse ……… isis called:called: -- Allergy Allergy
-- hypersensitivityhypersensitivity --atopyatopy
27-27- allall areare peripheralperipheral tolerancetolerance mechanismsmechanisms except:except: T-cell
T-cell killingkilling inin thethe thymusthymus
Cases Cases :: 28
28 -- aa boyboy waswas playingplaying outsideoutside ,, daysdays after after hehe comescomes homehome hehe developeddeveloped rashrash and
and irritationirritation of of thethe skin...skin... ,, thisthis typetype of of hypersensitivityhypersensitivity :: -- DelayedDelayed hypersensitivityhypersensitivity contactcontact dermatitisdermatitis ..
29
29 -- aa manman 6060 yearsyears oldold hadhad aa BMBM transplantationtransplantation ,, thethe operationoperation waswas successful
successful ,, 2-32-3 daysdays after after thethe operationoperation thethe manman developeddeveloped jundice jundice ,diarrhea,,diarrhea, hematouria
hematouria the
the typetype of of thisthis rejectionrejection isis :: -- hyperacutehyperacute rejectionrejection
-- acuteacute Graft-Versus-Graft-Versus- HostHost diseasedisease -- chronicchronic Graft-Versus-Graft-Versus- HostHost diseasedisease -- chronicchronic rejectionrejection
30
30 -- aa casecase aboutabout kidneykidney diseasedisease ,, inin thethe teststests therethere waswas antibodies
antibodies againstagainst glomerulusglomerulus basementbasement membranemembrane :: -- GoodpastureGoodpasture syndromesyndrome..
31
31 – – casecase …… thethe lablab testtest showedshowed thatthat thethe patientpatient hadhad c-ANCA,c-ANCA, what'swhat's thethe diagnosis?
diagnosis? Wegener's
Wegener's Granulomatosis.Granulomatosis. 32
32 -- WhichWhich of of thethe followingfollowing isis wrongwrong aboutabout adjuvantsadjuvants a)
a) theythey actact asas antigenantigen depotdepot b)
c)
c) theythey makemake anyany moleculemolecule immunogenicimmunogenic d
d) ) tthhey ey ccaauuse se lloocacall inflammationinflammation 33
33 -- AB+ AB+ childchild waswas bornborn toto anan AB- AB- mother,mother, hehe hadhad jaundice, jaundice, fever fever andand splenomegaly,
splenomegaly, directdirect coomb'scoomb's testtest resultresult willwill be:be: a)
a) Anti-Rh Anti-Rh antibodiesantibodies boundbound toto thethe mother'smother's erythrocyteserythrocytes b)
b) AnAntiti-R-Rh h anantitibobodidies es bobounund d to to ththe e ininfafantnt's 's ererytythrhrococytyteses c)
c) Anti-A Anti-A andand Anti-B Anti-B inin thethe infant'sinfant's serumserum
34-34- RAG-1RAG-1 andand RAG-2RAG-2 areare downregulateddownregulated inin somesome stagesstages of of B-cellB-cell development,
development, soso thth atat eacheach BB cellcell willwill havehave onlyonly oneone specificity.specificity. TheThe underlyingunderlying mechanism
mechanism isis a)
a) somaticsomatic hypermutationhypermutation b)
b) classclass switchingswitching c)
c) affinityaffinity maturationmaturation d)
d) alallelelilic c exexclclususioionn 35
35 -- Aspirin Aspirin mediatesmediates itsits effectseffects throughthrough blockingblocking thethe synthesissynthesis of of a)
a) leuktriensleuktriens b)
b) proprostastaglaglandinndinss c)
c) histaminehistamine 36
36 -- A A personperson hadhad aa rarerare pan-T-cellpan-T-cell deficiency.deficiency. OnOn performingperforming flowflow cytometrycytometry byby the
the FACSFACS machine,machine, whichwhich cellcell marker marker willwill bebe thethe leastleast inin number number ?? a) a) CD19CD19 b b) ) CCDD33 c) c) CD5CD5 d) d) CD11aCD11a 37
37 -- CertainCertain skinskin diseasesdiseases areare aa resultresult of of highhigh number number of of activatedactivated TT cells.cells. OneOne hypothesis
hypothesis sayssays thatthat wewe cancan useuse thethe tetanustetanus toxoidtoxoid toto fightfight thesethese disease.disease. Which
Which of of thethe followingfollowing cytokinescytokines cancan givegive thethe bestbest resultsresults if if conjugatedconjugated toto thethe toxoid
toxoid ?? a)
a) IL-2IL-2 b)
b) TNFTNF-a-alplphaha c)
c) IL-4IL-4 d)
d) IFN-gammaIFN-gamma 38
38 -Which-Which of of thethe followingfollowing cytokinescytokines willwill bebe mostmost numerousnumerous inin thethe brainbrain of of aa patient
patient withwith multiplemultiple sclerosissclerosis ?? a)
39
39 -- [A[A casecase aboutabout rheumatoidrheumatoid arthritis]arthritis] TheThe patientpatient hashas joint joint painpain inin thethe ankles,ankles, wrists.
wrists. TheThe rheumatoidrheumatoid factor factor inin serumserum == 100100 ,, ESRESR == (elevated).(elevated). WhichWhich of of thethe following
following antibodiesantibodies mainlymainly contributescontributes toto thethe pathogenesispathogenesis of of thethe diseasedisease ?? a)
a) IgMIgM againstagainst IgGIgG b)
b) IgAIgA againstagainst synovialsynovial cellscells c)
c) IgMIgM againstagainst histoneshistones d)
d) IgGIgG againstagainst dsDNAdsDNA e)
e) IgGIgG againstagainst topoisomerasetopoisomerase II enzyme.enzyme. 40
40 -- A A patientpatient hashas undergoneundergone stemstem cellcell transplantation.transplantation. HeHe didn'tdidn't showshow anyany signs
signs of of rejectionrejection for for 33 days,days, thenthen hehe hadhad somesome macular macular yellowyellow rashesrashes onon thethe skin,
skin, withwith abnormalabnormal liver liver functionfunction test,test, abnormalabnormal creatinine,creatinine, (…many(…many things!).things!). What's
What's mostmost probablyprobably happeninghappening ?? a)
a) HyperacuteHyperacute graftgraft rejectionrejection b)
b) acuteacute graftgraft rejectionrejection c
c) ) aacucutte e GVGVHDHD d)chronic
d)chronic GVHDGVHD e)
e) chronicchronic rejectionrejection
41
41 )) TheThe disorder disorder relatedrelated toto abnormalabnormal actinactin functionfunction is:is: a)
a) Wiskot-AldrichWiskot-Aldrich syndrome.syndrome.
-- A A patientpatient withwith staphylococcalstaphylococcal infectioninfection hadhad normalnormal IgMIgM butbut lowlow IgA,IgA, IgGIgG levelslevels in
in serum.serum. WhichWhich of of thethe followingfollowing isis deficient?deficient? a) a) CD(B7)CD(B7) b) b) CD80CD80 c) c) CD40CD40 d) d) CDCD4040LL 42
42 )) CiclosporinCiclosporin andand tacrolimustacrolimus belongbelong toto whichwhich classclass of of immunosuppressantsimmunosuppressants ?? a)
a) antiprolirferativesantiprolirferatives b)
b) IL-2IL-2 blockersblockers c)
c) T-cT-celelll signsignalialing ng bloblockackadede d)
d) corticosteroidscorticosteroids 43
43 )) [A[A casecase aboutabout glomerulonephritis]glomerulonephritis] thethe patientpatient hadhad elevatedelevated bloodblood ureaurea nitrogen,
nitrogen, bronchospasm,bronchospasm, reddishreddish urine,urine, thethe diagnosisdiagnosis waswas rapidlyrapidly propagatingpropagating glomerulonephritis.
glomerulonephritis. WhichWhich of of thethe followingfollowing isis ture?ture? a)
a) therethere shouldshould bebe aa lotlot of of mastmast cellscells inin thethe tissuetissue b)
b) therethere areare antibodiesantibodies reactingreacting againstagainst tissuetissue antigensantigens 44)
44) InIn cross-matching,cross-matching, wewe use:use: a)indirect
b)
b) directdirect coomb'scoomb's testtest 45)
45) All All of of thethe followingfollowing areare likelylikely toto induceinduce tolerancetolerance exceptexcept a)
a) anatomicanatomic sequestrationsequestration b)
b) introductionintroduction of of antigenantigen duringduring embryogenesisembryogenesis c)
c) introductionintroduction of of antigenantigen toto immatureimmature cellscells d)
d) strongstrong bindingbinding toto autoantigenautoantigen e)
e) a a papatthhoogegen n bibindndiing ng tto o a a sselelff-a-antntiigegenn 46)
46) All
All of of thethe followingfollowing areare truetrue aboutabout adjuvantadjuvant EXCEPT:EXCEPT: &
& All All of of thethe followingfollowing areare truetrue aboutabout atopyatopy EXCEPT:EXCEPT: So
So youyou mustmust focusfocus inin thesethese termsterms ..
46
46 )) WhichWhich drugdrug willwill hopefullyhopefully causecause sterilizingsterilizing immunityimmunity inin HIVHIV infectioninfection a)
a) IL-7IL-7 b
b) ) IILL--22 47
47 )) [a[a case]case] …… thethe patientpatient hadhad nono lymphoidlymphoid progenitors…Whichprogenitors…Which of of thesethese isis likely
likely toto bebe abscent?abscent? Answer:
Answer: IL-7IL-7 48)
48) WhichWhich of of thethe followingfollowing hashas itsits onlyonly FcFc portionportion fromfrom humanhuman originsorigins a)
a) humanizedhumanized mAbsmAbs b)
b) chchiimemerriic c mAmAbsbs c)
c) phagephage librarieslibraries 49)
49) OneOne methodmethod toto increaseincrease thethe half-lifehalf-life of of IFN-aphaIFN-apha inin thethe treatmenttreatment of of Hepatitis
Hepatitis BB isis byby PEGylation
PEGylation
-- TheThe firstfirst thingthing toto dodo whenwhen preparingpreparing for for transplantationtransplantation isis toto checkcheck a)
a) major major HLAHLA compatibilitycompatibility b)
b) minor minor HLAHLA == c)
50)
50) [a[a case]…thecase]…the patientpatient hadhad antibodiesantibodies againstagainst thethe basementbasement membranemembrane of of the
the kidney,kidney, what'swhat's your your diagnoisisdiagnoisis ?? Goodpasture's
Goodpasture's syndromesyndrome -51
-51 )) WhichWhich cellcell decidesdecides thethe polarizationpolarization of of adaptiveadaptive immuneimmune response(response( toto Th1Th1 or
or Th2)Th2) is:is: a
a) ) AAPPCC b)
b) naïvenaïve TT cellcell c)Tregs
c)Tregs
-- 52)52) ThereThere werewere twotwo questionsquestions aboutabout thethe associationassociation betweenbetween ChronicChronic granulomatous
granulomatous diseasedisease andand thethe NBTNBT test.test.
-- WhichWhich of of thethe followingfollowing cancan bebe producedproduced fromfrom thethe MHCMHC genesgenes onon thethe shortshort armarm of
of chromosomechromosome 66 a)
a) cocomplmplemeementnt C3C3 b)
b) complementcomplement C5C5
-- 53)53) aa casecase aboutabout SCID.SCID. WhichWhich of of thethe followingfollowing isis wrong?wrong? The
The patient'spatient's genesgenes areare normal.normal.
-- 54)54) MonoclonalMonoclonal Abs Abs thatthat havehave thethe humanhuman constantconstant regionregion areare called:called: -- humanizedhumanized
-- ChimericChimeric -transgenic -transgenic
-55)
-55) Case:Case: fever,fever, dyspneadyspnea && hemoglobinuria,,hemoglobinuria,, thethe immunofleorescenseimmunofleorescense testtest showed
showed linear linear immuneimmune complexcomplex precipitation..precipitation.. thisthis typetype of of autoimmuneautoimmune diseasedisease is
is mediatedmediated by:by:
-- solublesoluble Ag Ag againstagainst fixedfixed Abs Abs
-- stimulationstimulation of of cellscells byby autoantibodiesautoantibodies
-- cell-mediatedcell-mediated immunityimmunity && GranulomaGranuloma formationformation -56)
-56) 9-year-old9-year-old childchild withwith recuurentrecuurent staphylococcalstaphylococcal infection,infection, differentialdifferential CBCCBC showed
showed normalnormal PMNPMN count,,count,, further further teststests willwill mostmost likelylikely show:show: -- complementcomplement deficiencydeficiency
-low
-low CD4+CD4+ cellcell countcount -- -ve-ve NBTNBT testtest
57)
57) autopsyautopsy of of abortedaborted fetusfetus showedshowed absentabsent peripheralperipheral countscounts of of TT && BB cellscells although
although hishis BMBM containedcontained normalnormal number number of of lymphoidlymphoid precursors,,precursors,, if if deficiencydeficiency in
in oneone IL-receptor IL-receptor waswas responsibleresponsible for for thisthis case>>case>> it'sit's mostmost likelylikely toto be:be: --IL-7IL-7
-IL-1 -IL-1 -IL-2 -IL-2 -IL-3 -IL-3 58)
58) *the*the mostmost informativeinformative sentencesentence aboutabout mastmast cells:cells:
-- theythey causecause inflammationinflammation notnot onlyonly cuzcuz of of histaminehistamine releaserelease butbut alsoalso duedue toto metabolism
metabolism of of A.A. A.A. 59)
59) whichwhich cytokinecytokine cancan induceinduce apoptosis:apoptosis: -IL-1 -IL-1 -IL-6 -IL-6 --TNFTNF 60)
60) whichwhich makesmakes lymphocyteslymphocytes && neutrophilsneutrophils slowslow or or stopstop atat sitesite of of extravasationextravasation from
from bloodblood vessels:vessels: -- LFA-1LFA-1 -ICAM-1 -ICAM-1 -VLA-4 -VLA-4 61)
61) neededneeded for for BB cellcell stimulation:stimulation: -- cytokinescytokines && occupationoccupation of of TCRTCR -- Ag Ag && cytokinescytokines
-- THTH cellcell && APC APC helphelp 62)
62) 2-year-old2-year-old toddler toddler sufferingsuffering diarrhea,diarrhea, recurrentrecurrent infectionsinfections && failurefailure toto thrive..thrive.. his
his parentsparents refusedrefused vaccinesvaccines for for religiousreligious reasons,,reasons,, examinationsexaminations revealedrevealed absent
absent thymusthymus gland;gland; hehe has:has: -- DiGeorgeDiGeorge syndromesyndrome
63)
63) Ags Ags expressedexpressed inin cancer cancer && tissuestissues fromfrom whichwhich theythey arise,arise, belongsbelongs toto whichwhich type
type of of tumor tumor Ags: Ags: -- lineage-specificlineage-specific Ags Ags
64)
64) skinskin disorder disorder characterizedcharacterized byby over-activationover-activation of of T-cells..T-cells.. whichwhich cytokinecytokine isis most
most likelylikely toto bebe usedused conjugatedconjugated toto diphtheriadiphtheria toxoidtoxoid asas aa treatmenttreatment for for thisthis case: case: -- Inf-γInf-γ -IL-2 -IL-2 -IL-4 -IL-4 65)
-- defensindefensin
--hyphypochlochloruorus s aciacidd -- lactoferrinlactoferrin
-acidification
-acidification of of lysosymeslysosymes 66)
66) tumor tumor Ags Ags expressedexpressed inin tissuestissues duringduring fetalfetal life:life: -- developmentaldevelopmental Ags Ags
67)
67) CyclosporinCyclosporin mech.mech. Of Of Action: Action: -- intracellular intracellular signalingsignaling blockadeblockade 68)
68) allall truetrue except:except:
-- IgsIgs transportedtransported inin thethe lastlast monthmonth of of pregnancypregnancy -- IgsIgs transportedtransported viavia specializedspecialized FcRFcR inin placentaplacenta -- IgsIgs areare transportedtransported inin energy-dependentenergy-dependent mech.mech.
69)
69) casecase question:question: ……..…….. aa defectdefect inin thethe hypochlorushypochlorus acidacid thisthis willwill affectaffect :: The
The acidityacidity of of thethe lysosmeslysosmes 70)
70) casecase questionquestion :: ……… soso thethe patientpatient isis diagnoseddiagnosed withwith fewfew TT cellcell count,
count, thethe sitesite inin thethe LNLN thatthat isis mostmost likelylikely toto bebe affectedaffected thethe most?most? Paracortical
Paracortical area.area.
71)
71) A A boyboy waswas infectedinfected byby tetanustetanus infectioninfection ,, thethe doctor doctor isis notnot suresure thatthat hehe isis protected
protected fromfrom thethe tetanustetanus soso hehe givegive himhim aa booster booster of of tetanustetanus toxoidtoxoid thisthis typetype of
of immunityimmunity isis ::
)-)- artificiallyartificially activeactive immunityimmunity
72)
72) hehe mostmost commoncommon antibodiesantibodies inin thethe mucosalmucosal surfacesurface of of thethe genitalgenital track?(from
track?(from thethe first)first) IgA
IgA 73)
73) thethe randomrandom additionaddition of of nucleotidenucleotide byby TdTTdT isis inin ?? (from(from thethe first)first) Junctional
Junctional diverstydiversty
74)
74) TheThe changechange inin thethe antigenantigen bindingbinding sitesite toto createcreate aa higher higher affinityaffinity bindingbinding known
Somatic
Somatic hypermutaionhypermutaion 75
75 )) thethe childchild willwill useuse oneone chromosomechromosome fromfrom thethe parentsparents chromosomschromosoms thisthis isis known
known asas (( thethe questionquestion isis notnot inin thisthis formulaformula butbut thethe ideaidea isis thisthis !!!)?!!!)? Allelic
Allelic exclusion.exclusion.
76)
76) oneone of of thethe followingfollowing isis notnot correctcorrect aboutabout TITI :: (( notnot suresure aboutabout thethe formulaformula of of the
the question)question) It
It hashas aa memorymemory 77)
77) oneone of of thethe followingfollowing willwill notnot shareshare inin thethe synapsesynapse ?? (from(from thethe firstfirst )) CD3
CD3
78
78 )) oneone of of thethe followingfollowing isis notnot aa responsibilityresponsibility of of thethe anphlatoxinsanphlatoxins ?????????? II don’tdon’t remember remember thethe choiceschoices sorrysorry !!!!!!!!!!
79)
79) casecase questionquestion :………….:…………. SoSo hehe foundfound thatthat therethere areare immuneimmune complexescomplexes inin the
the kidneykidney thisthis anan indicationindication of of :: SLE
SLE 80)
80) oneone of of thethe followingfollowing isis notnot aa causecause of of secondarysecondary immuneimmune deficiencydeficiency ?? Mutations
Mutations 81)
81) moleculesmolecules producedproduced byby tumor tumor cellcell andand cancan bebe recognizedrecognized byby thethe immuneimmune system
system knownknown asas ?? Tumor
Tumor antigensantigens F
Frroom m tthhiis s tto o EENND D FFRROOM M HHAYAT AYAT AANND D SSHHIIFA FA EEXXAAMMS S :: 82)
82) Tumor Tumor correctcorrect exceptexcept a)
a) tyrosinasetyrosinase – – melanomamelanoma b)
b) CEACEA && GIGI cancer cancer c)
c) ViralViral EBVEBV – – LymphomaLymphoma d)
d) BCR-AblBCR-Ablfusionfusion proteinprotein – – multiplemultiplemyelomamyeloma e)
e) Alpha- Alpha- fetofeto proteinprotein –hepatoma –hepatoma 83)
83) HIVHIV virusvirus infectsinfects whichwhich cell?cell? a) a) NKNK b) b) CD-8CD-8 c) c) BB cellcell
d)
d) GlialGlial cellcell e)
e) BasophileBasophile 84
84 )) Factor Factor BB a)
a) IsIs thethe enzymaticenzymaticpartpart of of thethe C3C3 convertaseconvertaseinin thethe alternativealternativepathwaypathway b)
b) OnlyOnly componentcomponent of of complementcomplement pathwaypathway thatthat circulatecirculate activeactive enzymeenzyme c)
c) BindBind covalentlycovalently toto pathogenpathogen throughthrough thioster thioster bondbond d)
d) HasHas nono potentialpotential enzymaticenzymatic activityactivity e)
e) CleavageCleavage factor factor DD 85
85 )mostly)mostly affectedaffected byby INFINF typetype II (INF(INF alphaalpha andand beta)beta) a)
a) Aspergellus Aspergellus b)
b) PlasmodiumPlasmodium c)
c) ListeriaListeria bacteriabacteria d)
d) StaphylococcusStaphylococcus bacteriabacteria e)
e) InfluenzaInfluenza virusvirus 86)
86) TheThe enzymeenzyme neededneeded inin liberationliberation of of HIVHIV fromfrom infectedinfected cellcell a)
a) Gp120Gp120 b)
b) ProteaseProtease c)
c) ReverseReverse transcriptasetranscriptase d)
d) IntegraseIntegrase e)
e) CollagenaseCollagenase 87)Active
87)Active immunityimmunity cancer cancer exceptexcept a)
a) VaccinationVaccination byby tumor tumor antigenantigen b)
b) BCGBCG locallocal injectionsinjections c)
c) Anti-CD20Anti-CD20infusioninfusion d)
d) VaccinationVaccination byby wholewhole cellcell e)
e) IL-2IL-2 infusioninfusion 88
88 )) serumserum sicknesssickness exceptexcept a)
a) C-factor C-factor b)
b) MonovalentMonovalentantigenantigen c)
c) PersistencePersistence immuneimmune complexcomplex d)
d) NutrophilsNutrophils e)
e) EquivalenceEquivalence of of antigenantigen andand antibodyantibody 89
89 )) virusesviruses andand malignancymalignancy exceptexcept a)
a) HumanHuman papillomapapilloma virus-virus- cervicalcervical cancer cancer b)
b) EBVEBV – – lymphomalymphoma c)
c) HumanHumanherpesherpes virusvirus 88 andand lymphomalymphoma d)
e)
e) EBVEBV – – nasopharyngealnasopharyngeal 90)
90) eliminationelimination of of bacteriabacteria byby opsonizationopsonization a)
a) neutralizationneutralization of of bacterialbacterial toxintoxin b)
b) recognitionrecognitionof of bacteriabacteriaboundbound antibodiesantibodiesbyby FcFc receptor receptor onon macrophage
macrophage c)
c) preventionprevention of of bacteriabacteria adhesionadhesion toto endothelialendothelial cellcell d)
d) bindingbinding antibodiesantibodies FcFc onon bacteriabacteria e)
e) classclass 11 MHCMHC antigenantigen 91)
91) recombinationrecombination signalsignal sequencesequence bestbest describesdescribes a)
a) sequencesequence thatthat containcontain ITAM-ITAM- signalingsignaling BB cellcell b)
b) sequencesequencerecognizedrecognizedbyby RAG1RAG1 – – RAG2RAG2 c)
c) sequencesequence responsibleresponsible for for typetype switchingswitching inin BB cellcell d)
d) sequencesequence encodesencodes signalsignal peptidepeptide responsibleresponsible IgIg e)
e) sequencesequence RNARNA splicingsplicing eventevent IgM/IgDIgM/IgD 92)
92) MHCMHC II andand MHCMHC IIII a)
a) ConstituvelyConstituvely expressedexpressed byby mostmost cellscells inin thethe b)
b) expressedexpressedbyby MacrophageMacrophageandand dentriticdentritic cellcell c)
c) ConstituvelyConstituvely associatedassociated – – haptenhapten d)
d) ExpressedExpressed – – INFINF gammagamma
93)
93) InjectingInjecting ComplementComplement CC killingkilling antigen-Abantigen-Ab inin patientpatient lackslacks C3C3 a)
a) DepressDepress levellevel of of serumserum factor factor BB b)
b) IncreasedIncreased chemotacticchemotactic C5aC5a serumserum levellevel c)
c) IncreasedIncreased serumserum levellevel of of C8C8 d)
d) DecreasedDecreasedlevellevel of of C2C2 94)
94) TrophoblastTrophoblast ….…. ImmunologicalImmunological phenomenonphenomenon exceptexcept a)
a) antibodyantibody againstagainst paternalpaternal antigensantigens b)
b) IncreasedIncreased HLA-HLA- GG antigensantigens c)
c) DecreasedDecreased MHCMHC II d)
d) BlockingBlocking antibodyantibody e)
e) IncreasedIncreasedCD8-CD8- TT recognitionrecognition 95)
95) WhichWhich oneone isis false?false? a)
a) MastMast cellcell :: ILIL 1212 b)
b) TH2TH2 :: IL6IL6 c)
c) TH1TH1 :: INFINF gammagamma d)
96)
96) RegardingRegarding pregnancy,pregnancy, whichwhich isis wrong?wrong? a)
a) Androgen Androgen suppresssuppress T/BT/B cellscells b)
b) EstrogenEstrogen suppresssuppress TT cellscells c)
c) PlacentaPlacentaTHTH11 suppresssuppressTT cellcell d)
d) NKNK cellcell suppressedsuppressed byby increasedincreased HLA-GHLA-G
97)
97) A A 1010 yearsyears oldold boyboy hashas recurrentrecurrent skinskin andand lunglung infectionsinfections byby staphylococcusstaphylococcus aureus,
aureus, whatwhat cancan bebe foundfound atat hishis diagnosisdiagnosis a)
a) LowLow IgM,IgM, absenceabsence of of BB cellcell b)
b) LowLow IgIg lowlow BB cellcell c)
c) LowLow terminalterminal complementcomplement d)
d) AbnormalAbnormalNBNBTT testtest 98)
98) PulmonaryPulmonary edemaedema thatthat followsfollows incompatibleincompatible transfusiontransfusion resultsresults inin a)
a) Donor Donor WBWBCC antibodiesantibodiesagainstagainst recipientrecipientgranulocytesgranulocytes 99)
99) DuringDuring B-cellB-cell developmentdevelopment thethe rearrangementrearrangement inin IgIg lociloci a)
a) DHDH toto JHJH,, DJDJ toto VHVH,, VLVL toto JLJL 100)
100) Activation Activation of of maturemature BB cellcell requiresrequires twotwo signalssignals a)
a) An An antigenantigen andand TT cellcell helphelp b)
b) TCTCRR occupancyoccupancyandand TT cellcell help???help??? c)
c) AntigenAntigenandand cytokines???cytokines??? d)
d) TCRTCR occupancyoccupancy andand cytokinescytokines 101)
101) TheThe BMBM transplantationtransplantation isis thethe mostmost difficultdifficult ……..…….. a)
a) HyperacuteHyperacute b)
b) Acute Acute rejectionsrejections c)
c) GVHDGVHD d)
d) ToleranceTolerance 102)
102) MacrophagesMacrophages secretessecretes allall exceptexcept a)
a) IL-IL- 66 b)
b) IL-8IL-8 c)
c) INFINF gammagamma d)
d) TNFTNF alphaalpha 103)
103) CausesCauses tolerancetolerance rather rather thethe immunityimmunity a)
a) InsolubleInsoluble antigenantigen b)
b) HeterologousHeterologous antigenantigen c)
c) ParticulateParticulate antigenantigen d)
e)
e) InjectingInjectingantigenantigen toto fetusfetus inin developmentdevelopment 104
104 )) Autoimmune Autoimmune diseasedisease a)
a) ShowsShowsHLHLAA associationassociation b)
b) RunRun aa steadysteady clinicalclinical coursecourse c)
c) Affect Affect bothboth sexessexes equallyequally d)
d) areare triggeredtriggered byby differentdifferent antigenantigen inin differentdifferent individualsindividuals 105)
105) CyclosporineCyclosporine A A inhibitsinhibits a)
a) CalcineriumCalcinerium 106
106 )) NotNot usedused asas anan evadingevading mechanismmechanism byby virusesviruses a)
a) MutationMutation b)
b) ProductionProductionof of cytotoxiccytotoxicAbAbss c)
c) DownregulatinDownregulatin of of MHCMHC classclass II moleculesmolecules d)
d) DestroyingDestroying thethe immuneimmune systemsystem 107
107 )) WhichWhich onon isis notnot involvedinvolved inin respiratoryrespiratory burstburst pathwaypathway of of neutrophilsneutrophils killingkilling a)
a) PhospholipaseCPhospholipaseC gammagamma 108)
108) InvolvedInvolved inin stoppingstopping lymphocytelymphocyte inin HEVHEV a)
a) L-selectinL-selectin b)
b) LFA-1LFA-1 109)
109) RestrictionRestriction meansmeans a)
a) TheThe recognitionrecognitionof of self self MHMHCC withwith antigenantigenbyby TT cellscells 110)
110) WhichWhich of of thethe followingfollowing isis wrongwrong regardingregarding thethe fetus?fetus? a)
a) ReversedReversed numnum of of pmnpmn andand lymphocyteslymphocytes b)
b) NoNo IgM,IgM, IgA,IgA, IgGIgG 111)
111) ComplementComplement activationactivation a)
a) Activate Activate haptenhapten b)
b) ActiveActive C1C1qq bindsbinds antigen-antibodycomplexantigen-antibodycomplex c)
c) C3C3 convertaseconvertase C4bc2bC4bc2b d)
d) C3C3 convertaseconvertase C3bBbC3bBb e)
e) RegulateRegulate factor factor HH
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