Ramez Haddadin, MD. (617)

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Ramez Haddadin, MD

ramez@post.harvard.edu

(617) 331 4888

Bio

Ramez Haddadin, MD grew up in the Chicagoland and Northwest Indiana area.

After graduating

summa cum laude

from the University of Pennsylvania, he moved

to Boston and completed his medical degree with honors from Harvard Medical

School. Dr. Haddadin received several research grants while in Boston and

subsequently completed the Harvard Ophthalmology Residency Program for which

he was honored the Alcon Resident Excellence award. He subspecialized in Cornea

and Refractive Surgery at the Massachusetts Eye & Ear Infirmary, Harvard Medical

School with recognition as a Heed Fellow as well as Chief Fellow.

Having participated in over 1500 eye surgeries, Dr. Haddadin is trained in all

aspects of general ophthalmology, cornea and refractive surgery. He has

performed hundreds of cataract surgeries and was recognized with awards for his

work. Dr. Haddadin has performed over 100 eyelid surgeries and hundreds of

corneal procedures including cornea transplants and LASIK. While working in

Boston, he served as a teacher to senior residents of the Harvard Ophthalmology

Residency performing ophthalmic surgery.

Dr. Haddadin has relocated to Chicago with his wife and 2 year-old son. He is

currently teaching residents at Stroger Hospital, and is the Director of the

Ophthalmology Division of Provident Hospital of Cook County. He also

participates in Chicago-wide residency training events for ophthalmic surgery.

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Education

• Harvard Medical School, Boston, MA 09/2004 – 06/2009

Medical Degree, cum laude

Research Fellowship in Glaucoma, Howe Laboratory 07/2007 – 06/2008

• University of Pennsylvania, Philadelphia, PA 09/2000 – 05/2004

BSE in Bioengineering, minor in Chemistry; GPA: 3.95/4.0, summa cum laude

Postgraduate Work and Training

• Cook County Health & Hospitals System, Chicago, IL 2014 – present

John H. Stroger, Jr. Hospital - Attending Physician

Provident Hospital – Director of Ophthalmology Division

• Massachusetts Eye & Ear Infirmary, Boston, MA 07/2013 – 07/2014

Cornea & Refractive Surgery Fellowship (Chief Fellow), Harvard Medical School

• Harvard Ophthalmology Residency, Boston, MA 06/2010 – 06/2013

Massachusetts Eye & Ear Infirmary, Harvard Medical School

• Cambridge Health Alliance, Cambridge, MA 06/2009 – 06/2010

Transitional Internship Program, & Clinical Fellow at Harvard Medical School

Honors and Awards

• The Heed Ophthalmic Foundation Fellowship awardee 2013-2014 • Massachusetts House of Representatives recognition of “Outstanding 2013

Performance and Devotion in the Field of Cataract Surgery at the Veteran Health Care Center.”

• Massachusetts State Senate Offical Citation “Outstanding Service in 2013

Performing Cataract Surgery at the VA Hospital.”

• Alcon Resident Excellence Award 2013

• Fight for Sight Research Fellowship 2008

• National Eye Institute ARVO Travel Grant 2008

• Carl W. Walter Research Fellowship, Harvard Medical School 2007 - 2008 • Louis W. Gilbert Research Fellowship, Harvard Medical School 2005

• Herman P. Schwan Bioengineering Award, Univ. of Penn. 2004 • School-wide Senior Design Projects Competition, First Runner Up, 2004

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• Bioengineering Senior Design Award, University of Pennsylvania 2004

• Barry M. Goldwater Scholar 2003

• Tau Beta Pi Engineering Honor Society 2002 - present

• Arthur Lehman Scholarship 2004 - 2007

• Peter V. Westhaysen Medical Education Trust Merit Scholarship 2004 - 2005 • University Scholar, University Scholar Research Grant (2002), Univ. of Penn. 2000 - 2004 • Dean’s List, University of Pennsylvania 2000 - 2004 • Most Active Member of the Society of Bioengineers Award, Univ. of Penn. 2000 - 2001

Teaching and Mentoring Experience

• Attending Physician of Stroger & Provident Hospitals of Cook County 2014 – present • Attending Physician of Eye Trauma Service, Massachusetts Eye & Ear, 2013 – 2014

Harvard Medical School

• Penn Engineering Mentoring Program, 5/2012 – 6/2014

• Non-resident tutor at the Harvard College Leverett House for the 2007 – 2010

purposes of premedical advising,

• Patient-Doctor tutor; mentored 2nd-year Harvard medical students to 2007 – 2009

refine their doctoring skills

• Student Teaching Corps; held review sessions for Harvard Medical School 2006

• Teaching Assistant for “Properties of Biomaterials” to Dr. William Graham 2003 - 2004

at University of Pennsylvaia

• Teaching Assistant for Introduction to Engineering to Dr. David Pope 2003

at University of Pennsylvania

• Tutor in Mathematics (Calculus I – IV) at University of Pennsylvania 2001

Research

• Glaucoma; Douglas J. Rhee, MD., Mass. Eye & Ear Infirmary, 2007 – 2013

Studied the role of various matricellular proteins - including SPARC and thrombospondin - as they relate to intraocular pressure regulation. Studies involved the measurement of intraocular pressures of knockout mice as well as viral transfection to reintroduce proteins in knock-out mice. We also performed molecular and morphologic studies on aqueous outflow pathways including

immunohistochemistry as well as light, electron, and confocal microscopy. We also studied the role of SPARC in steroid-induced ocular hypertension and trabecular meshwork changes. I also

participated in studies involving anterior segment (organ explant) perfusion & in vitro models of trabecular meshwork.

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• Cartilage degeneration; Martha Gray, PhD., Harvard Institute of Medicine, 2005

Studied the biosynthetic response of cartilage to mechanical loading using radiolabeling, spectrophotometry, and MRI.

• Sleep Apnea; Allan Pack, MD., PhD., Center for Sleep Research, U. Penn., 2003 - 2004

Designed and built transcranial mouse oximeter for screening mice with ventilatory disorders, including sleep apnea.

• Lung Injury; Susan Margulies, PhD., Bioengineering, U. Penn., 2002 - 2003

Designed an incubator-housed, computer-driven, cell stretching device & studied its effects upon the cytoskeleton.

Publications

Peer-Reviewed Publications

• Haddadin RI, Chodosh J. Corneal Transplantation and Glaucoma. Seminars in Ophthalmology

(accepted 7/2014)

• Wiggs J, Pawlyk B, Connolly E, Adamian M, Miller J, Pasquale L, Haddadin R, Grosskreutz C,

Rhee D, Li T. LOXL1 deficiency causes disruption of the blood-aqueous barrier and cataract. Invest Ophthalmol Vis Sci 2014 Feb 10;55(2):856-64.

• Simon SS, Chee Y, Haddadin RI, Veldman PB, Borboli-Gerogiannis S, Brauner SC, Chang KK,

Chen SH, Gardiner MF, Greenstein SH, Kloek CE, Chen TC. Achieving Target Refraction After Cataract Surgery. Ophthalmology 2014 Feb;121(2):440-4.

• Keller KE, Vranka JA, Haddadin RI, Kang MH, Oh DJ, Rhee DJ, Yang YF, Sun YY, Kelley MJ,

Acott TS. The effects of tenascin C knockdown on trabecular meshwork outflow resistance. Invest Ophthalmol Vis Sci. 2013 Aug 19;54(8):5613-23.

• Vora GK, Haddadin RI, Chodosh J. Management of Corneal Lacerations and Perforations. Int

Ophthalmol Clin. 2013 Fall;53(4):1-10.

• Haddadin RI, Vora GK, Chodosh J. Corneal Trauma following Keratoplasty. Int Ophthalmol

Clin. 2013 Fall;53(4):23-32.

• Haddadin RI, Oh DJ, Kang MH, Villarreal G Jr., Kang JH, Jin R, Gong H, Rhee DJ.

Thrombospondin-1 (TSP1)-Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures.

Invest Ophthalmol Vis Sci: 2012 Sep 28;53(10):6708-17.

• Chatterjee A, Oh DJ, Kang MH, Haddadin R, Villarreal G, Toetenberg M, Swaminathan S,

Rhee DJ. The Role of SPARC in Trabecular Meshwork Extracellular Matrix Turnover and IOP Regulation. Glaucoma Today 2012 (September-October).

• Haddadin RI, Dohlman CH. Keratoprosthesis in congenital hereditary endothelial dystrophy

after multiple failed grafts. Digital Journal of Ophthalmology. September 23, 2011. Volume 17, Number 3.

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• Haddadin RI, Oh DJ, Kang MH, Filippopoulos T, Gupta M, Hart L, Sage EH, Rhee DJ.

SPARC-null Mice Exhibit Lower Intraocular Pressures. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3771-7 Epub 2009 Jan 24.

• Rhee DJ, Haddadin RI, Kang MH, Oh DJ. Matricellular proteins in the trabecular meshwork.

Exp Eye Res. 2009 Apr;88(4):694-703. Epub 2008 Dec 11.

Manuscripts in preparation

• Haddadin RI, Oh DJ, Rhee DJ. Inhibitory Effect of Secreted Protein Acidic and Rich in

Cysteine (SPARC) on Corticosteroid-Induced Ocular Hypertension. (manuscript in

preparation).

• Oh DJ, Haddadin RI, Rhee DJ. SPARC is not involved in latanoprost-induced changes in

intraocular pressure, nor in trabecular meshwork or ciliary body smooth muscle cells.

(manuscript in preparation).

Book Chapter

• Haddadin RI, Rhee DJ. Control of Intraocular Pressure. In: Nouri K, ed. Lasers in

Dermatology and Medicine: Laser/Light Applications in Ophthalmology. New York, NY:

Springer. 2012, pages 447-461. Paper Presentations

• Haddadin RI, Oh D,Peck RE, Sage EH, Rhee DJ. Dexamethasone Administration Affects

SPARC Expression in Human Trabecular Meshwork and Increases IOP in SPARC-null Mice. Invest Ophthalmol Vis Sci. 2011: ARVO E-Abstract 882. Glaucoma Models Session. Abstracts

• Haddadin RI, Oh DJ, Rhee DJ. Latanoprost Lowers Intraocular Pressure in Matrix

Metalloproteinase 9-null Mice. Invest Ophthalmol Vis Sci. 2013: ARVO E-Abstract 789.

• Lefebvre DR, Chandra RV, Haddadin R, Ogilvy CS, Freitag SK. Anterior Orbital Vascular

Malformation Mimicking a Carotid-Cavernous Sinus Fistula. American Society of Ophthalmic Plastic and Reconstructive Surgery Spring Meeting 2012.

• Haddadin RI, Oh DJ, Rhee DJ. SPARC Is Not Involved In Latanoprost-induced Changes In

Intraocular Pressure, Nor In Trabecular Meshwork Or Ciliary Body Smooth Muscle Cells.

Invest Ophthalmol Vis Sci. 2012: ARVO Abstract 253.

• Wiggs JL, Pawlyk B, Connolly E, Xu X, Adamian M, Kim IK, Miller JW, Rhee D, Haddadin RI, Li

T.Phenotypic Characterization of the LOXL1 Null Mouse. Invest Ophthalmol Vis Sci. 2009: ARVO E-Abstract 882.

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• Oh DJ, Haddadin RI, Rhee DJ. Thrombospondin-1 and -2 Knockout Mice Have Lower

Intraocular Pressures. Invest Ophthalmol Vis Sci. 2009: ARVO E-Abstract 4847.

• Haddadin RI. SPARC-null mice have lower intraocular pressures. Harvard Medical School Soma Weiss Student Research Day, April 2009. Boston, MA.

• Haddadin RI, Oh DJ, Gupta M, Sage EH, Rhee DJ. SPARC-null mice have lower intraocular

pressures. Invest Ophthalmol Vis Sci. 2008: ARVO E-Abstract 1609.

• Haddadin RI, Gray ML. Biosynthetic Response of Human Articular Cartilage Explants to Static

Loading. Harvard Medical School Soma Weiss Student Research Day, April 2006. Boston, MA.

• Gabriel N, Haddadin R, Margulies S. Prolonged stretch increases alveolar epithelial cell death. Biomedical Engineering Society. 2004 Annual Fall Meeting. Univ. of Pennsylvania,

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