Ramez Haddadin, MD
ramez@post.harvard.edu(617) 331 4888
Bio
Ramez Haddadin, MD grew up in the Chicagoland and Northwest Indiana area.
After graduating
summa cum laude
from the University of Pennsylvania, he moved
to Boston and completed his medical degree with honors from Harvard Medical
School. Dr. Haddadin received several research grants while in Boston and
subsequently completed the Harvard Ophthalmology Residency Program for which
he was honored the Alcon Resident Excellence award. He subspecialized in Cornea
and Refractive Surgery at the Massachusetts Eye & Ear Infirmary, Harvard Medical
School with recognition as a Heed Fellow as well as Chief Fellow.
Having participated in over 1500 eye surgeries, Dr. Haddadin is trained in all
aspects of general ophthalmology, cornea and refractive surgery. He has
performed hundreds of cataract surgeries and was recognized with awards for his
work. Dr. Haddadin has performed over 100 eyelid surgeries and hundreds of
corneal procedures including cornea transplants and LASIK. While working in
Boston, he served as a teacher to senior residents of the Harvard Ophthalmology
Residency performing ophthalmic surgery.
Dr. Haddadin has relocated to Chicago with his wife and 2 year-old son. He is
currently teaching residents at Stroger Hospital, and is the Director of the
Ophthalmology Division of Provident Hospital of Cook County. He also
participates in Chicago-wide residency training events for ophthalmic surgery.
Education
• Harvard Medical School, Boston, MA 09/2004 – 06/2009
Medical Degree, cum laude
Research Fellowship in Glaucoma, Howe Laboratory 07/2007 – 06/2008
• University of Pennsylvania, Philadelphia, PA 09/2000 – 05/2004
BSE in Bioengineering, minor in Chemistry; GPA: 3.95/4.0, summa cum laude
Postgraduate Work and Training
• Cook County Health & Hospitals System, Chicago, IL 2014 – present
John H. Stroger, Jr. Hospital - Attending Physician
Provident Hospital – Director of Ophthalmology Division
• Massachusetts Eye & Ear Infirmary, Boston, MA 07/2013 – 07/2014
Cornea & Refractive Surgery Fellowship (Chief Fellow), Harvard Medical School
• Harvard Ophthalmology Residency, Boston, MA 06/2010 – 06/2013
Massachusetts Eye & Ear Infirmary, Harvard Medical School
• Cambridge Health Alliance, Cambridge, MA 06/2009 – 06/2010
Transitional Internship Program, & Clinical Fellow at Harvard Medical School
Honors and Awards
• The Heed Ophthalmic Foundation Fellowship awardee 2013-2014 • Massachusetts House of Representatives recognition of “Outstanding 2013
Performance and Devotion in the Field of Cataract Surgery at the Veteran Health Care Center.”
• Massachusetts State Senate Offical Citation “Outstanding Service in 2013
Performing Cataract Surgery at the VA Hospital.”
• Alcon Resident Excellence Award 2013
• Fight for Sight Research Fellowship 2008
• National Eye Institute ARVO Travel Grant 2008
• Carl W. Walter Research Fellowship, Harvard Medical School 2007 - 2008 • Louis W. Gilbert Research Fellowship, Harvard Medical School 2005
• Herman P. Schwan Bioengineering Award, Univ. of Penn. 2004 • School-wide Senior Design Projects Competition, First Runner Up, 2004
• Bioengineering Senior Design Award, University of Pennsylvania 2004
• Barry M. Goldwater Scholar 2003
• Tau Beta Pi Engineering Honor Society 2002 - present
• Arthur Lehman Scholarship 2004 - 2007
• Peter V. Westhaysen Medical Education Trust Merit Scholarship 2004 - 2005 • University Scholar, University Scholar Research Grant (2002), Univ. of Penn. 2000 - 2004 • Dean’s List, University of Pennsylvania 2000 - 2004 • Most Active Member of the Society of Bioengineers Award, Univ. of Penn. 2000 - 2001
Teaching and Mentoring Experience
• Attending Physician of Stroger & Provident Hospitals of Cook County 2014 – present • Attending Physician of Eye Trauma Service, Massachusetts Eye & Ear, 2013 – 2014
Harvard Medical School
• Penn Engineering Mentoring Program, 5/2012 – 6/2014
• Non-resident tutor at the Harvard College Leverett House for the 2007 – 2010
purposes of premedical advising,
• Patient-Doctor tutor; mentored 2nd-year Harvard medical students to 2007 – 2009
refine their doctoring skills
• Student Teaching Corps; held review sessions for Harvard Medical School 2006
• Teaching Assistant for “Properties of Biomaterials” to Dr. William Graham 2003 - 2004
at University of Pennsylvaia
• Teaching Assistant for Introduction to Engineering to Dr. David Pope 2003
at University of Pennsylvania
• Tutor in Mathematics (Calculus I – IV) at University of Pennsylvania 2001
Research
• Glaucoma; Douglas J. Rhee, MD., Mass. Eye & Ear Infirmary, 2007 – 2013
Studied the role of various matricellular proteins - including SPARC and thrombospondin - as they relate to intraocular pressure regulation. Studies involved the measurement of intraocular pressures of knockout mice as well as viral transfection to reintroduce proteins in knock-out mice. We also performed molecular and morphologic studies on aqueous outflow pathways including
immunohistochemistry as well as light, electron, and confocal microscopy. We also studied the role of SPARC in steroid-induced ocular hypertension and trabecular meshwork changes. I also
participated in studies involving anterior segment (organ explant) perfusion & in vitro models of trabecular meshwork.
• Cartilage degeneration; Martha Gray, PhD., Harvard Institute of Medicine, 2005
Studied the biosynthetic response of cartilage to mechanical loading using radiolabeling, spectrophotometry, and MRI.
• Sleep Apnea; Allan Pack, MD., PhD., Center for Sleep Research, U. Penn., 2003 - 2004
Designed and built transcranial mouse oximeter for screening mice with ventilatory disorders, including sleep apnea.
• Lung Injury; Susan Margulies, PhD., Bioengineering, U. Penn., 2002 - 2003
Designed an incubator-housed, computer-driven, cell stretching device & studied its effects upon the cytoskeleton.
Publications
Peer-Reviewed Publications
• Haddadin RI, Chodosh J. Corneal Transplantation and Glaucoma. Seminars in Ophthalmology
(accepted 7/2014)
• Wiggs J, Pawlyk B, Connolly E, Adamian M, Miller J, Pasquale L, Haddadin R, Grosskreutz C,
Rhee D, Li T. LOXL1 deficiency causes disruption of the blood-aqueous barrier and cataract. Invest Ophthalmol Vis Sci 2014 Feb 10;55(2):856-64.
• Simon SS, Chee Y, Haddadin RI, Veldman PB, Borboli-Gerogiannis S, Brauner SC, Chang KK,
Chen SH, Gardiner MF, Greenstein SH, Kloek CE, Chen TC. Achieving Target Refraction After Cataract Surgery. Ophthalmology 2014 Feb;121(2):440-4.
• Keller KE, Vranka JA, Haddadin RI, Kang MH, Oh DJ, Rhee DJ, Yang YF, Sun YY, Kelley MJ,
Acott TS. The effects of tenascin C knockdown on trabecular meshwork outflow resistance. Invest Ophthalmol Vis Sci. 2013 Aug 19;54(8):5613-23.
• Vora GK, Haddadin RI, Chodosh J. Management of Corneal Lacerations and Perforations. Int
Ophthalmol Clin. 2013 Fall;53(4):1-10.
• Haddadin RI, Vora GK, Chodosh J. Corneal Trauma following Keratoplasty. Int Ophthalmol
Clin. 2013 Fall;53(4):23-32.
• Haddadin RI, Oh DJ, Kang MH, Villarreal G Jr., Kang JH, Jin R, Gong H, Rhee DJ.
Thrombospondin-1 (TSP1)-Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures.
Invest Ophthalmol Vis Sci: 2012 Sep 28;53(10):6708-17.
• Chatterjee A, Oh DJ, Kang MH, Haddadin R, Villarreal G, Toetenberg M, Swaminathan S,
Rhee DJ. The Role of SPARC in Trabecular Meshwork Extracellular Matrix Turnover and IOP Regulation. Glaucoma Today 2012 (September-October).
• Haddadin RI, Dohlman CH. Keratoprosthesis in congenital hereditary endothelial dystrophy
after multiple failed grafts. Digital Journal of Ophthalmology. September 23, 2011. Volume 17, Number 3.
• Haddadin RI, Oh DJ, Kang MH, Filippopoulos T, Gupta M, Hart L, Sage EH, Rhee DJ.
SPARC-null Mice Exhibit Lower Intraocular Pressures. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3771-7 Epub 2009 Jan 24.
• Rhee DJ, Haddadin RI, Kang MH, Oh DJ. Matricellular proteins in the trabecular meshwork.
Exp Eye Res. 2009 Apr;88(4):694-703. Epub 2008 Dec 11.
Manuscripts in preparation
• Haddadin RI, Oh DJ, Rhee DJ. Inhibitory Effect of Secreted Protein Acidic and Rich in
Cysteine (SPARC) on Corticosteroid-Induced Ocular Hypertension. (manuscript in
preparation).
• Oh DJ, Haddadin RI, Rhee DJ. SPARC is not involved in latanoprost-induced changes in
intraocular pressure, nor in trabecular meshwork or ciliary body smooth muscle cells.
(manuscript in preparation).
Book Chapter
• Haddadin RI, Rhee DJ. Control of Intraocular Pressure. In: Nouri K, ed. Lasers in
Dermatology and Medicine: Laser/Light Applications in Ophthalmology. New York, NY:
Springer. 2012, pages 447-461. Paper Presentations
• Haddadin RI, Oh D,Peck RE, Sage EH, Rhee DJ. Dexamethasone Administration Affects
SPARC Expression in Human Trabecular Meshwork and Increases IOP in SPARC-null Mice. Invest Ophthalmol Vis Sci. 2011: ARVO E-Abstract 882. Glaucoma Models Session. Abstracts
• Haddadin RI, Oh DJ, Rhee DJ. Latanoprost Lowers Intraocular Pressure in Matrix
Metalloproteinase 9-null Mice. Invest Ophthalmol Vis Sci. 2013: ARVO E-Abstract 789.
• Lefebvre DR, Chandra RV, Haddadin R, Ogilvy CS, Freitag SK. Anterior Orbital Vascular
Malformation Mimicking a Carotid-Cavernous Sinus Fistula. American Society of Ophthalmic Plastic and Reconstructive Surgery Spring Meeting 2012.
• Haddadin RI, Oh DJ, Rhee DJ. SPARC Is Not Involved In Latanoprost-induced Changes In
Intraocular Pressure, Nor In Trabecular Meshwork Or Ciliary Body Smooth Muscle Cells.
Invest Ophthalmol Vis Sci. 2012: ARVO Abstract 253.
• Wiggs JL, Pawlyk B, Connolly E, Xu X, Adamian M, Kim IK, Miller JW, Rhee D, Haddadin RI, Li
T.Phenotypic Characterization of the LOXL1 Null Mouse. Invest Ophthalmol Vis Sci. 2009: ARVO E-Abstract 882.
• Oh DJ, Haddadin RI, Rhee DJ. Thrombospondin-1 and -2 Knockout Mice Have Lower
Intraocular Pressures. Invest Ophthalmol Vis Sci. 2009: ARVO E-Abstract 4847.
• Haddadin RI. SPARC-null mice have lower intraocular pressures. Harvard Medical School Soma Weiss Student Research Day, April 2009. Boston, MA.
• Haddadin RI, Oh DJ, Gupta M, Sage EH, Rhee DJ. SPARC-null mice have lower intraocular
pressures. Invest Ophthalmol Vis Sci. 2008: ARVO E-Abstract 1609.
• Haddadin RI, Gray ML. Biosynthetic Response of Human Articular Cartilage Explants to Static
Loading. Harvard Medical School Soma Weiss Student Research Day, April 2006. Boston, MA.
• Gabriel N, Haddadin R, Margulies S. Prolonged stretch increases alveolar epithelial cell death. Biomedical Engineering Society. 2004 Annual Fall Meeting. Univ. of Pennsylvania,
