Program
July 9 (Tue)
15:00-17:00 Registration
17:20-17:30 Opening Remarks: Keiji TANAKA
Plenary Lecture
Chair: Keiji TANAKA
17:30-18:30
New insights into biochemical mechanisms of the 26S proteasome
Department of Cell Biology, Harvard Medical School, USA
Alfred L. GOLDBERG
18:40-20:00 Welcome Reception
July 10 (Wed)
7:00-8:50 Breakfast
Session A:
Basic Mechanisms of the Proteasome
Chairs: Wolfgang P. BAUMEISTER, Keiji TANAKA
9:00-9:30 A-1
Recent advances in structural studies of the 26S proteasome
Department of Structural Biology, Max-Planck-Institute of Biochemistry, Germany
Wolfgang P. BAUMEISTER
9:30-10:00 A-2
Regulation of proteasome activity
Department of Cell Biology, Harvard Medical School, USA
Daniel FINLEY
10:00-10:30 A-3
BAG6 is essential for selective elimination of aggregation-prone defective proteins
Department of Biological Sciences, Tokyo Metropolitan University, Japan
Program 11:00-11:15 A-4
(41)
Proteasomal degradation resolves competition between cell polarization and cellular wound healing
Graduate School of Medical Science, Nagoya City University, Japan
Keiko KONO
11:15-11:30 A-5 (35)
Structure and function of moyamoya disease-associated AAA+ ATPase!ubiquitin ligase mysterin
Faculty of Life Sciences, Kyoto Sangyo University, Japan
Daisuke MORITO
11:30-12:00 A-6
In-depth analysis of cellular dynamism of the proteasome
Tokyo Metropolitan Institute of Medical Science, Japan
Keiji TANAKA
12:00-12:30 A-7
Regulation of eukaryotic proteasome assembly
Department of Molecular Biophysics and Biochemistry, Yale University, USA
Mark HOCHSTRASSER
Number in parenthesis: poster number
12:30-14:00 Lunch
Session B:
Regulation of Ubiquitylation
Chairs: Raymond DESHAIES, Shigetsugu HATAKEYAMA
14:00-14:30 B-1
Regulation of culling-RING ubiquitin ligases
California Institute of Technology, USA
Raymond DESHAIES
14:30-15:00 B-2
Ubiquitin-dependent regulation of ASK1 stress signaling in cell death
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Hidenori ICHIJO
15:00-15:30 B-3
Functional analysis of F-box proteins in vivo
School of Medicine, Tohoku University, Japan
Keiko NAKAYAMA
Program
16:00-16:15 B-4 (46)
Real-time, label-free monitoring of poly ubiquitin chain formation with bacterial ubiquitin ligase
Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Japan
Minsoo KIM
16:15-16:30 B-5 (19)
Recognition of K63-linked ubiquitin chains by the Ankrd13 family of UIM-bearing proteins regulates endocytosis of plasma membrane proteins
Department of Biological Sciences, Tokyo Institute of Technology, Japan
Masayuki KOMADA
16:30-17:00 B-6
Regulation of cellular functions by TRIM proteins
Department of Biochemistry, Hokkaido University, Japan
Shigetsugu HATAKEYAMA
17:00-17:30 B-7
The HRD ubiquitin ligase: managing protein quality control and ubiquitylation to maintain protein homeostasis in the secretory pathway
Cancer Department, Max-Delbrück-Center for Molecular Medicine, Germany
Thomas SOMMER
Number in parenthesis: poster number
17:30-19:00 Dinner
19:00-21:00 Poster Session [I]
July 11 (Thu)
7:00-8:50 Breakfast
Keynote Lecture
Chair: Kazuhiro IWAI The ubiquitin proteolytic system-from basic mechanisms thru human diseases and on to drug development
Program
Session C:
Diverse Roles of Ubiquitylation
Chairs: Kazuhiro IWAI, Stefan JENTSCH
9:40-10:10 C-1
Linear polyubiquitination: a new regulator of NF-κB activation
Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Japan
Kazuhiro IWAI
10:10-10:40 C-2
Structural basis of ubiquitin chain recognition
Department of Structural Biology, Stanford School of Medicine, Stanford University, USA
Soichi WAKATSUKI
10:40-11:10 Coffee Break
11:10-11:25 C-3 (20)
Stabilization of mouse CRY proteins by FBXL21 is critical for circadian oscillation of the biological clock.
∼Molecular characterization of FBXL21 in circadian clockwork∼
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Japan
Arisa HIRANO
11:25-11:40 C-4 (31)
Functional analysis of budding yeast SCFYlr224w E3 ligase
Graduate School of Science, Nagoya University, Japan
Takumi KAMURA
11:40-12:10 C-5
Ubiquitin-fold modifier 1 as a transcriptional regulator
Department of Biological Sciences, Seoul National University, Korea
Chin Ha CHUNG
12:10-12:40 C-6
Relevance of substrate-selective and protein group SUMOylation for nuclear activities
Department of Molecular Cell Biology, Max-Planck-Institute of Biochemistry, Germany
Stefan JENTSCH
Number in parenthesis: poster number
Program
Session D:
Pathophysiological Roles of the
Proteasome
Chairs: Ron R. KOPITO, Shigeo MURATA
14:00-14:30 D-1
Presentation of unique peptide repertoire on MHC class I by the thymoproteasome
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Shigeo MURATA
14:30-15:00 D-2
Immunoproteasomes in the regulation of protein homeostasis
Institute of Biochemistry, Charité-Universitätsmedizin Berlin, Germany
Peter-Michael KLOETZEL
15:00-15:30 D-3
Immunoproteasomes and human diseases
Department of Immunology, The University of Tokushima, Japan
Koji YASUTOMO
15:30-16:00 Coffee Break
16:00-16:15 D-4 (32)
A missense mutation in Psmb11 impairs thymoproteasome assembly and T cell development
Department of Immunology and Pathology, National Center for Global Health and Medicine, Japan
Takeshi NITTA
16:15-16:30 D-5 (43)
Loss of MHC class II ubiquitination negatively regulates dendritic cells
Laboratory of integrative infection immunology, Showa Pharmaceutical University, Japan
Satoshi ISHIDO
16:30-17:00 D-6
Regulation of leaf organ size and gene silencing by plant proteasome
Research Faculty of Science, Hokkaido University, Japan
Junji YAMAGUCHI
17:00-17:30 D-7
The role of protein aggregation and ubiquitylation in the pathogenesis of Huntingtons disease
Program
17:30-19:00 Dinner
19:00-21:00 Poster Session [II]
July 12 (Fri)
7:00-8:50 Breakfast
Session E:
Ubiquitin and Diseases
Chairs: Keiichi NAKAYAMA, Michele PAGANO
9:00-9:30 E-1
Control of cell proliferation by SCF ubiquitin ligases and its relevance in human cancers
Howard Hughes Medical Institute and Department of Pathology, NYU Cancer Institute, New York University School of Medicine, USA
Michele PAGANO
9:30-10:00 E-2
Fbw7 is essential for maintenance of quiescence and function of cancer stem cells
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Japan
Keiichi NAKAYAMA
10:00-10:30 E-3
Identification of a primary target of thalidomide’s complex biological effects
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
Hiroshi HANDA
10:30-11:00 Coffee Break
11:00-11:15 E-4 (48)
Coordinated functions of BRCA1, Claspin and HERC2 in DNA damage response and cell cycle
Department of Translational Oncology, St. Marianna University Graduate School of Medicine, Japan
Tomohiko OHTA
11:15-11:30 E-5 (7)
Identifying HECT E3 ubiquitin ligase substrate pairs by mechanism based approach
Department of Chemistry, Northwestern University, USA
Program
11:30-12:00 E-6
Regulation of cullin-RING ligases by viral deneddylases
Department of Cell and Molecular Biology, Karolinska Institutet, Sweden
Maria MASUCCI
12:00-12:30 E-7
The Keap1-Nrf2 system for environmental response
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan
Masayuki YAMAMOTO
Number in parenthesis: poster number 12:30-12:45 Announcement
12:45-12:50 Closing Remarks: Kazuhiro IWAI
