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From proteomics to discovery of first-in-class ST2 inhibitors active in vivo

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Figure

Figure 1. Flowchart of integrated high-throughput screening and computational analysis for discovery of ST2 inhibitors
Figure 2. In vitro and in vivo toxicity evaluation of selected candidates. (ing to chemotypes I, II, and III and unclassified are grouped together
Figure 3. IC50point is an average of triplicate measurements ± SD. (of the Kratky plot based on the SAXS profiles of apo-ST2 and ST2/iST2-1, the pair-wise distance distribution [the SAXS profiles
Figure 4. Dosages and treatment schedule for ST2 inhibitors and ex
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