Michael A. Samuel, MD

California Center

Fax: 626-284-8636

www. researchcalifornia. corn

LICENSE State of California Medical License No. A83237 State of Ohio Medical License - 2007

State of Pennsylvania Medical License - 2005 State of New Jersey Medical License - 2006 DEA: FSO435710

CERTIFICATION Board Certified - American Board of Ophthalmology - 2004 & MEMBERSHIP American Academy of Ophthalmology

American Society of Retinal Specialists

The Association for Research in Vision and Ophthalmology

PROFESSIONAL California Center for Clinical Research

AFFILIATIONS 207 S. Santa Anita, Suite P30 San Gabriel, CA 91776 Tel: (626) 284-8401 Fax: (626) 284-8636

Retina Institute of California

301 W. Huntington Drive, Suite 107 Arcadia, CA 91007

Tel: (626) 574-0188 Fax: (626) 574-0488

Retina Institute of California 800 S. Fairmount Ave., Ste 312 Pasadena, CA 91105

Tel: (626) 568-8839 Fax: (626) 583-8838

Retina Institute of California 17138-B Colima Road Hacienda Heights, CA 91745 Tel: (626) 965-8895

Fax: (626) 965-8876

Retina Institute of California 72301 Country Club Dr., Ste 109 Rancho Mirage, CA 92270 Tel: (760) 779-0800 Fax: (760) 779-0801

Retina Institute of California 160 E. Artesia Street, Ste 120 Pomona, CA 91767

Tel: (909) 629-5965 Tel: (909) 629-5968

EDUCATION & Fellowships:

TRAINING Vitreo-Retinal Surgery

Doheny Retina Institute / University of Southern California 2004 — 2005

Pediatric Vitreo-Retinal Surgery & Ocular Oncology Children's Hospital Los Angeles

University of Southern California 2003 — 2004

Residency:

Ophthalmology

Henry Ford Health System Detroit, MI

2000 — 2003

Internship:

Transitional Year

Mount Carmel Medical Center Columbus, OH

1999 -2000

Graduate:

Meharry Medical College — M.D. Nashville, TN

1995 - 1999

Undergraduate:

Capital University, B.A. Columbus, OH

1992 - 1995

PROFESSIONAL 2010 — Present

POSITIONS California Center for Clinical Research San Gabriel, CA

Medical Director 2009-Present

Retina Institute of California Pasadena, CA

2008-2009

Columbus Eye Center — The Retina Group Columbus, OH

2008-2009

Nationwide Children's Hospital Columbus, OH

2004-2008

Wills Eye Hospital — Attending Retina Service Philadelphia, PA

Thomas Jefferson University — Assistant Professor of Ophthalmology Philadelphia, PA

2004-2008

Children's Hospital of Philadelphia — Clinical Affiliate Philadelphia, PA

Central Montgomery Medical Center Lansdale, PA

Montgomery Hospital Norristown, PA

RESEARCH, "A PHASE III, DOUBLE-MASKED, MULTICENTER,

CLINICAL TRIALS RANDOMIZED, ACTIVE TREATMENT-CONTROLLED STUDY

OF THE EFFICACY AND SAFETY OF 0.5mg AND 2.0mg DRUG ADMINISTERED MONTHLY OR ON AN AS NEEDED BASIS (PRN) IN PATIENTS WITH SUBFOVEAL NEOVASCULAR AGE-RELATED MACULAR DEGENERATION"

"A 24-MONTH RANDOMIZED, DOUBLE-MASKED, CONTROLLED, MULTICENTER, PHASE IIIB STUDY ASSESSING SAFETY AND EFFICACY OF DRUG PHOTODYNAMIC THERAPY ADMINISTERED IN

CONJUNCTION WITH DRUG VERSUS DRUG MONOTHERAPY IN PATIENTS WITH SUBFOVEAL CHOROIDAL

NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION"

"DRUG FOR EDEMA OF THE MACULA IN DIABETES: A PHASE 2 STUDY"

"A RANDOMIZED, SINGLE-MASKED, LONG-TERM, SAFETY, AND TOLERABILITY STUDY OF INTRAVITREAL DRUG IN

SUBJECTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION"

"A DOUBLE-MASKED, RANDOMIZED, CONTROLLED STUDY OF THE SAFETY, TOLERABILITY AND BIOLOGICAL EFFECT OF REPEATED INTRAVITREAL ADMINISTRATION OF DRUG IN PATIENTS WITH DIABETIC MACULAR EDEMA (DME)"

"A RANDOMIZED, DOUBLE-MASKED, ACTIVE CONTROLLED

PHASE III STUDY OF THE EFFICACY, SAFETY, AND

TOLERABILITY OF REPEATED DOSES OF INTRAVITREAL DRUG IN SUBJECTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION"

"A PHASE III, MULTICENTER, RANDOMIZED, SHAM

INJECTION-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF DRUG INJECTION COMPARED WITH SHAM IN SUBJECTS WITH MACULAR EDEMA SECONDARY TO BRANCH RETINAL VEIN OCCLUSION"

"A PHASE III, MULTICENTER, RANDOMIZED, SHAM

INJECTION-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF DRUG INJECTION COMPARED WITH SHAM IN SUBJECTS WITH MACULAR EDEMA SECONDARY TO CENTRAL RETINAL VEIN OCCLUSION"

"AN OPEN-LABEL, MULTICENTER EXTENSION STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF DRUG IN SUBJECTS WITH CHOROIDAL NEOVASCULARIZATION (CNV) SECONDARY TO AGE-RELATED MACULAR DEGENERATION (AMD) OR MACULAR EDEMA SECONDARY TO RETINAL VEIN OCCLUSION (RVO) WHO HAVE COMPLETED A XXXXXX-SPONSORED DRUG STUDY"

"A PHASE III, DOUBLE-MASKED, MULTICENTER, RANDOMIZED, SHAM-CONTROLLED STUDY OF THE

EFFICACY AND SAFETY OF DRUG INJECTION IN SUBJECTS WITH CLINICALLY SIGNIFICANT MACULAR EDEMA WITH CENTER INVOLVEMENT SECONDARY TO DIABETES

MELLITUS"

"A PHASE 2, RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, DOSE-RANGING CLINICAL STUDY TO ASSESS THE SAFETY AND EFFICACY OF SUBCONJUNCTIVAL

INJECTIONS OF DRUG IN PATIENTS WITH DIABETIC MACULAR EDEMA SECONDARY TO DIABETIC

RETINOPATHY"

"A RANDOMIZED, DOUBLE MASKED, CONTROLLED PHASE 3 STUDY OF THE EFFICACY, SAFETY, AND TOLERABILITY OF REPEATED INTRAVITREAL ADMINISTRATION OF DRUG IN SUBJECTS WITH MACULAR EDEMA SECONDARY TO CENTRAL RETINAL VEIN OCCLUSION (CRVO)"

Principal Investigator, CABERNET trial, 2007

Cnv Secondary Amd Treated with BEta RadiatioN Epiretinal Therapy. NeoVista Inc, Fremont, CA

Principal Investigator, RADICAL trial, 2007

Reduced Fluence Visudyne-Anti-VEGF-Dexamethasone In Combination jar AMD Lesions. QLT Inc. Vancouver, BC

Diabetes Research Training Program -Vanderbilt University -1996 Vanderbilt University Research Grant -1996 -97 -Wound healing

using the Free Electron Laser (FEL).

HONORS & AOS-Knapp Fellowship Award — 2004 AWARDS

Outstanding Resident Award 2003 - 8 of 600+ residents in Henry

Ford Health System

Barsky Award - Study design and implementation. 2004 HFHS

Meharry Public Service Award co-founding the Vanderbilt - Meharry

Program for Prenatal Health.

PEER REVIEWED Samuel MA, Kaufman SC, Ahee JA, Wee C, Bogorad D. Diffuse PUBLICATIONS lamellar keratitis associated with carboxymethylcellulose sodium 1%

(Celluvisc) after laser in situ keratomileusis. J of Cataract & Refract

Surg. 2002 Sep;28(9):1651-4

Ahee JA, Kaufman SC, Samuel MA. Decreased incidence of epithelial defects during lasik with intraoperative carboxymethylcellulose 0.5% solution. J Cataract Refract Surg. 2002Aug;28(8):1409-11.

Samuel MA, Gandolfo C, Desai DR. Peripapillary retinal detachment

after radial optic neurotomy for central retinal vein occlusion. Retina. 2003 Aug;23(4):580-3.

Samuel MA, Desai DR, Strassman I, Abusamak M. Intraocular

bicarbonate fortified BSS as an infusate during pars plana vitrectomy.

Indian J Ophthalmol. 2003 Sep;51(3):237-42.

Trick G, Samuel MA. Clinical applications of short wave length automated perimetry. Comprehensive Ophthalmol Update. 2003 Nov;4(6):269-76

Raman SV, Desai DR, Anderson S, Samuel MA. Visual prognosis in patients with traumatic choroidal rupture. Can J Ophthalmol. 2004 Apr;39(3):260-6.

Tawansy KA, Samuel MA. Retinopathy of prematurity: practical surgical management in the new millennium. Techniques in

Ophthalmology 2004 Jun;2(2):60-65.

Kiahmi M, Samuel MA, Desai DR, Imami NR. Familial HLA-A2B7 associated anterior uveitis. Can J Ophthalmol. 2004 Oct;39(6):664-6

Samuel MA, Desai UR. Ocular trauma associated with Pickwickian

Syndrome. Journal of Injury - Online journal 2004, July

Kuarana RN, Charonis A, Samuel MA, Gupta A, Tawansy KA. Intravenous foscarnet in the management of acyclovir-resistant herpes simplex virus type 2 in acute retinal necrosis in children. Med Sci

Monit. 2005 Nov 24;11(12):CS75-78

Khurana RN, Samuel MA, Murphree AL, Loo RH, Tawansy KA. Subfoveal nodule in Coats' disease. Clin Experiment Ophthalmol. 2005 Jun;33(3):301-2.

Tawansy KA, Samuel MA, Shammas M, Murphree AL. Vitreoretinal complications of retinoblastoma treatment. Retina. 2006 Sep;26(7 Suppl):S47-52.

Samuel MA, Equi RA, Chang TS, Mieler W, Jampol LM, Hay D,

Yannuzzi LA. Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): new observations and a proposed staging system. Ophthalmology. 2007 Aug;114(8):1526-1529.el.

Lam HD, Samuel MA, Rao NA, Murphree AL. Retinoblastoma presenting as Coats' disease. Eye. 2007 Nov 30.

Hsu J, Kaiser RS, Sivalingam A, Abraham P, Fineman MS, Samuel MA, et al. Intravitreal bevacizumab (avastin) in central retinal vein occlusion. Retina. 2007 Oct;27(8):1013-9.

ABSTRACTS Samuel MA. Treating CNV Caused By AMD with Verteporfin PDT

and Bevacizumab: The Registry ofVisudyne0 AMD Therapy Database. Retina Society Meeting. 2007 Boston.

Samuel MA, Tawansy KA, Oppenheimer N. Rhegmatogenous

retinal detachment in neonatal retinopathy of prematurity. ARVO 2005. Poster

Hill JR, Crawford BD, Samuel MA, Tawansy KA. Evaluation of open-globe injuries of children in the last 15 years. ARVO 2005. Poster

Samuel MA, Tawansy KA. (2004) Current indications for scleral

buckling in neonatal rop retinal detachment. 22"d Annual Meeting

American Society of Retina Specialists, San Diego, CA. Paper

Shammas MC, Samuel MA, Murphree AL. (2004) Late recurrence of intraocular retinoblastoma. 22"d Annual Meeting American Society

of Retina Specialists, San Diego, CA. Paper

Lam D, Tawansy KA, Samuel MA. (2004) Smoldering retinopathy of prematurity: late onset neonatal retinal detachment. 22nd Annual

Meeting American Society of Retina Specialists, San Diego, CA.

Paper

Samuel MA, Stewart JM, Tawansy KA. (2004) Open-sky vitrectomy

for pediatric retinal detachments. Doheny Eye Institute Alumni Meeting. Los Angeles, CA. Paper.

Samuel MA, Tawansy KA. (2003) Top ten reasons for a pediatric

vitreo-retinal consult. Doheny Retina Forum, Los Angeles, CA. Paper.

Samuel MA, Tawansy KA, Murphree AL. (2003) Vitreo-retinal

complications of retinoblastoma. 21st Annual Meeting American

Society of Retina Specialists, New York, NY. Paper.

Samuel MA, Jackson J, Adusumalli M. (1996). Characterization of the

free electron laser (FEL) in a diabetic model of impaired wound healing. Vanderbilt University Diabetes Research Symposium, Nashville, Tennessee. Paper

Samuel MA, Kaufman SC, Ahee JA, Wee C, Bogorad D. (2001).

Diffuse lanlellar keratitis associated with carboxymethylcellulose sodium 1% (Celluvisc) after laser in situ keratomileusis. Henry Ford

Samuel MA, Desai DR, Strassman I, Abusamak M, Schiffman RM.

(2002). Intraocular irrigating solutions: a clinical study of BSS Plus and dextrose bicarbonate fortified BSS as an infusate during pars plana vitrectomy. Henry Ford Hospital Alumni Meeting -Eye Care Services, Detroit, Michigan.

Bhatti RA, Samuel MA, Fantin A, Dennehy P, Desai DR, Bachyinski B. (2005). The role of fetal hemoglobin in the development and progression of retinopathy of prematurity. ARVO 2005. Poster Pons M, Samuel MA, Murphree AL. (2004) Regression patterns of retinoblastoma after primary chemotherapy and local consolidation.

Annual Meeting American Society of Retina Specialists, San Diego,

CA. Poster.

Khurana R, Charonis A, Samuel MA, Tawansy KA. (2004)

Pediatric acute retinal necrosis resistant to acyclovir and responsive to foscarnet. Annual Meeting American Society ofRetina

Specialists, San Diego, CA. Poster.

Samuel MA, Tawansy KA, Murphree AL, Roa NA. (2004) Clinical

and fluorescein angiographic characteristics of late-onset retinoblastoma with coats' response in children. ARVO -Poster Lam DH, Tawansy KA, Samuel MA. (2004) Delayed retinal vascular maturation and late onset macular dragging and retinal detachment in neonates with retinopathy of prematurity. ARVO -Poster

Khaimi M, Samuel MA, Desai UR, Imami NR, Schiffinan RM. (2002) Familial HLAA2B7 associated anterior uveitis. Retina

Congress --The Combined Meeting, San Francisco, California.

Poster.

Abdulhak MM, Samuel MA, Desai UR, Edwards PA. (2002) Retinal manifestations of patients with sickle cell trait. Retina Congress -The

Combined Meeting, San Francisco, California. Poster.

Desai UR, Gandolfo CB, Samuel MA. (2002). Timing of macula-on retinal detachment surgery. Retina Congress -The Combined Meeting, San Francisco, California. Poster

Deasi UR, Raman SV, Edwards PA, Gandolfo CB, Samuel MA. (2002). Visual outcomes of choroidal ruptures. Retina Congress -The