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Fundamental design principles for transcription factor based metabolite biosensors

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Figure

Figure 1A. Since Eq. (8) scales with both
424 FIGURES 425 426 Figure 1. Design constraints in dose-response curves of metabolite biosensors
Figure 2. Control of biosensor dose-response curves with tunable parameters. (A) Dose-response curves predicted from the model for biosensors with variable operator affinities
Figure 3: Orthogonal control of biosensor dynamic range and threshold.  (A) Dose-response curves of the lac strains from Figure 1C induced with TMG, which has a 10-fold lower affinity to LacI than IPTG

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