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Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

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Figure

Figure 1 Individual-patient trough FEV 1 data with LOESS curve, with zoom-in on the LOESS curve in the range 1200-1500 mL.
Table 2 Posterior summaries for parameters from the model of trough FEV 1 at steady state in the study-level analysis Mean SD Q2.5 Q50 (median) Q97.5 Model parameters E max (mL) 177 13 152 176 206 ED 50 ( μg) 28 10 12 26 52 Derived parameters ED 90 ( μg) 1
Figure 6 Left: patient-level dose response data by baseline FEV 1 category (quartiles) with LOESS curves through the data; Right:
Figure 8 Impact of baseline FEV 1 and dose on the improvement in trough FEV 1 relative to baseline.

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