1-34 Parathyroid Hormone
Effects of Parathyroid Hormone on Skeletal Muscle Protein and Amino Acid Metabolism in the Rat
... parathyroid hormone and the synthetic 1-34 fragment of this hormone stimulated the release of alanine and glutamine from muscle of control but not from chronically uremic ...of ...
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Parathyroid hormone (1-34) promotes the effects of 3D printed scaffold-seeded bone marrow mesenchymal stem cells on meniscus regeneration
... efficacy [30]. In our study, the immunohistochemistry of meniscus implants in the BMSCs–scaffold group showed high expression of the chondrocyte terminal differentiation markers Col10 and MMP13, indicating the terminal ...
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Intermittent parathyroid hormone (1–34) supplementation of bone marrow stromal cell cultures may inhibit hypertrophy, but at the expense of chondrogenesis
... Figure 1 provides a schematic of how the Microwell- mesh enables the rapid manufacture and culture of hun- dreds of uniform ...for 1 h at room temperature, followed by 3 washes with sterile phosphate- ...
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Poly(lactic-co-glycolic acid) Microspheres Containing a Recombinant Parathyroid Hormone (1-34) for Sustained Release in a Rat Model
... Recombinant parathyroid hormone (1-34), the drug of choice for treating severe osteoporosis, has a short half- life and requires daily subcutaneous ...recombinant parathyroid ...
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Human Parathyroid Hormone IMMUNOLOGICAL CHARACTERIZATION OF ANTIBODIES AGAINST A GLANDULAR EXTRACT AND THE SYNTHETIC AMINO TERMINAL FRAGMENTS 1 12 AND 1 34 AND THEIR USE IN THE DETERMINATION OF IMMUNOREACTIVE HORMONE IN HUMAN SERA
... human parathyroid tumors and to the synthetic NH 2 -terminal fragments of human parathyroid hormone hPTH-(1-12) and -(1-34) were developed in goats to characterize ...
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Enhancement of the effects of intermittent parathyroid hormone (1-34) by bone morphogenetic protein in a rat femoral open fracture model
... The explanted femoral bones obtained at the 6–week time point were photographed using a Softex X-ray apparatus (Softex CSM-2; Softex, Tokyo, Japan) using HS Fuji Softex film (Fuji Film, Tokyo, Japan) at 45 cm with 30 kV ...
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Effects of a synthetic peptide of a parathyroid hormone related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents
... first 34 amino acids of the parathyroid hormone- related protein (PTH-rP) produced by a human tumor associated with hypercalcemia was examined for skeletal and renal effects on calcium metabolism in ...
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The combined effect of Parathyroid hormone (1 34) and whole body Vibration exercise in the treatment of OSteoporosis (PaVOS) study protocol for a randomized controlled trial
... WBV therapy may also improve blood circulation in muscle and bone and increase the supply of nutrients needed to build bones [16]. Platforms for WBV are now commercially available and are used in gyms, as an alternative ...
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Expression of parathyroid hormone/parathyroid hormone-related peptide receptor 1 in normal and diseased bladder detrusor muscles: a clinico-pathological study
... Detrusor muscle tissues in normal control bladders stained positive for PTH1R, especially in the cytosol. This result seems to contradict the fact that PTH1R is a membrane-anchored G protein-coupled receptor, [14] ...
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Absence of functional receptors for parathyroid hormone and parathyroid hormone related peptide in Blomstrand chondrodysplasia
... Functional properties and expression of the mutant recep- tor. To investigate the functional consequences of the muta- tion, a sequence encoding a 12–amino acid epitope tag was added to the COOH-terminal end of the ...
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Effect of parathyroid hormone on erythropoiesis
... concentration of Ep in the media from 0.67 to 1.9 U/ml overcame the inhibitory effect of 1-84 bPTH on BFU-E. The N-terminal fragment of PTH (1-34 bPTH) and 53-84 hPTH had no effect on BFU-E. The ...
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Short term effects of synthetic human parathyroid hormone (1 34) administration on bone mineral metabolism in osteoporotic patients
... that parathyroid hormone can stimulate bone formation and increase trabecular bone, and patients with primary and secondary hyperparathyroidism may exhibit osteosclerosis, we evaluated the effect of ...
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Comparison of postreceptor effects of 1 34 human hypercalcemia factor and 1 34 human parathyroid hormone in rat osteosarcoma cells
... the parathyroid hormone (PTH) receptor was recently purified, cloned, and found to have NH2-terminal sequence homology with ...The 1-34 region of this protein was synthesized, evaluated for ...
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In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1 34 for the treatment of osteoporosis
... and 1% Chitosan and ...stage 1 in 25,000 dilution; 1/125 in PBS/ 0.5% BSA followed by 1/200 in McCoy’s 5A/ ...(Table 1). This placed formulations with PTH (1-34) at a ...
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Triweekly administration of parathyroid hormone (1–34) accelerates bone healing in a rat refractory fracture model
... The failure of a fracture to unite represents an important problem in clinical practice. Off-label clinical use of PTH (1–34) is becoming an increasingly used option in challenging fractures and delayed ...
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Rapid development of renal resistance to low doses of synthetic bovine parathyroid hormone fragment 1 34 Dissociation of urinary cyclic adenosine monophosphate, phosphaturic, and calciuric responses
... phenomenon that is clearly shown to occur in vitro. Large amounts of PTH given to human subjects as serial injections or prolonged infusions cause decreased urinary 3',5'-cyclic adenosine monophosphate (cAMP) responses ...
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Dose dependent effect of parathyroid hormone 1 34 fragment and its influence mechanism on the functional activity of isolated heart
... of parathyroid hormone (PTH), its paracrine analog, parathyroid hormone-related protein (PTHrP) and electrolytes in blood of patients with heart ...PTH 1-34 is combined with ...
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Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex
... The formation of nanocomplexes was confirmed by dynamic light-scattering and TEM. The complex between amphiphilic LysDOCA and rhPTH (1-34) had a particle size of 33.0 ± 3.36 nm and a zeta potential of 2.85 ...
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Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro
... intact hormone (parathyroid hormone 1--84) as well as amino- and carboxyl-terminal ...the hormone were also released when the tissue was exposed to high Ca++, but the carboxyl fragments ...
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Thyrocalcitonin, EGTA, and Urinary Electrolyte Excretion
... hydroxyproline without a change in glomerular filtration rate. The changes in phosphate excretion may be due to a direct effect of the hormone upon renal tubular function or they may be a consequence of the fall ...
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