1,4-dihydropyridines
Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4 Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation
... 1,4-Dihydropyridines (1,4-DHPs) belong to a class of nitrogen containing heterocycles having a six-mem- bered ring. Much attention has been devoted to explore their pharmacological activities. A considerable ...
9
Efficient Procedure for Preparation of 1,4-Dihydropyridines under Green Chemistry Conditions
... A simple, straightforward and economical method has been described for synthesis of 1,4-dihydropyridines. This method offers advantages in terms of mild experimentation conditions, economic catalyst, good to ...
5
One pot synthesis, antibacterial, dna photocleavage and sar studies of some fused 1,4 dihydropyridines via symmetrical hantzsch condensation
... The chemistry of 1,4-dihydropyridines (1,4-DHPs) found birth in 1882 with Hantzsch condensation (Hantzsch, 1882). After Hantzsch, multifarious new methods have been nurtured for the synthesis of original compounds ...
9
A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... 1,4-Dihydropyridines (1,4-DHPs) are core structure of many bioactive compounds which include vasodilator, bronchodilator, anticonvulsant, antidepressive, antianxiety, analgesic, antitumoral, hypnotic and ...
7
2D QSAR Studies on 1, 4 dihydropyridines as Ca++ Channel Blockers
... of 1, 4- dihydropyridines like amlodipine are extensively used in therapy of cardio vascular ...of 1, 4- dihydropyridines was selected and different models based on Multiple ...
7
Synthesis, characterization and pharmacological evaluation of some 1,4 dihydropyridines derivatives
... . On the molecular level 1,4-dihydropyridine compounds causes vaso relaxation by blocking voltage operated calcium channel in smooth muscle cell and also by increasing no release from intact endothelium 5 . The ...
6
Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
... PEG, (polyethylene glycol), is known to be inexpensive, thermally stable, recoverable, biological compatible, and non-toxic [19]. Their potential as reaction media and promotor for organic reaction has attracted the ...
6
Synthesis, Charecterisation and biological Evaluation of Novel Hantzsch 1,4 dihydropyridines
... Dihydropyridines (Eisner and Kuthan, 1972; Stout and Meyers, 1982; Kappe, 1993, 2003) represent important and extensively studied compounds belonging to the class of calcium channel blockers. Many researchers have ...
5
SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES
... The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- ...
5
Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
... of growth medium and cultured until 80% confluence and serum starved for 24 h. Then, cells were washed twice with PBS and treated with tested agents at concentrations rang- ing from 1 to 100 μ g/mL over 24 h. ...
14
Green Synthesis and Characterization of Bi2O3 Nanorods as Catalyst for Aromatization of 1,4-Dihydropyridines
... to successfully catalyse the Hantzsch aromatization of 1,4-DHPs. The effect of the amount of catalyst and time on aromatization of 1,4 dihydro-4-phenyl-2,6 dimethyl- 3,5 pyridinedicarboxylate designated as 1,4-DHP ...
6
A Novel Dihydropyridines C Glycosylated Compound by Hantzsch Cyclo Condensation
... novel Dihydropyridines C-Glycosylated ...[3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosy- lated-based ...The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan- ...
13
“Design and Molecular Docking Studies of Some 1,3,4-Oxadiazole Derivatives” by Dinesh Rishipathak, Prabhakar Shirodkar, India.
... 1,3, 4-oxadiazoles containing hydantoins and 1,4-dihydropyridines were done using V life MDS Biopredicta module using cavity # 1 of open channel voltage gated Sodium channel protein (4F4L) and ...
5
A REVIEW ON THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PIPERIDIN 4 ONES K P Greeshma * and S Muthulingam
... Ethyl acetoacetate and ethyllevulinate have also been employed as the ketone component for the synthesis of piperidine-4-ones (Scheme 7a) 13, 31-34 . With ethyl acetoacetate, aromatic aldehyde gave ...
5
An Efficient Protocol for Synthesis of 1,4-dihydropyridine Derivatives by Using Graphene Oxide Nano Particles as a Catalyst
... Hantzsch first reported the synthesis of 1,4-dihydropyridines via the condensation of aldehyde, ethyl acetoacetate with ammonia in refluxing alcohol or acetic acid which requires longer reaction time and low to ...
7
Zn[(L)-proline]‚ as a Recyclable and Green Catalyst for Efficient and One-pot Three-Component Synthesis of 1,4-Dihydro- pyridines Under Solvent-Free and Microwave Irradiation Conditions
... In conclusion, we have successfully demonstrated the catalytic activity of Zn[(L)-proline]‚ in the synthesis of 1,4-dihydropyridines. The catalyst can be reused after a simple work-up, with a gradual decline for ...
5
CALCIUM CHANNEL CURRENTS IN CULTURED PARS INTERCEREBRALIS NEUROSECRETORY CELLS OF ADULT LOCUSTA MIGRATORIA
... All neurones were taken from adult Locusta migratoria of both sexes reared in a crowded colony under constant laboratory conditions. Neurones from the MNSC group were dissected from the tissue and dissociated ...
6
4 [4 Dimethylamino 1 (4 fluorophenyl) 1 hydroxybutyl] 3 (hydroxymethyl)benzonitrile
... The title compound, (I), was prepared as an intermediate in the synthesis of fluoxetine, a known antidepressant (Hervas et al., 1998). There are two independent molecules in the asymmetric unit, showing different ...
12
4 (4 Carboxybenzyl) 1 methylpiperazin 1 ium picrate
... The title compound was prepared by taking equimolar quantities of picric acid (0.92 g, 2 mmol) and 4-[(4-methyl- piperazin-1-yl)methyl]benzoic acid (0.47 g, 2 mmol) and dissolving them in water. The ...
8
SYNTHESIS AND BIOLOGICAL EVALUATION OF 6 ARYL 3 CYANO 4 [4’ (p METHYLBENZYLOXY) 3’ METHOXYPHENYL] 2 OXO 1,2 DIHYDROPYRIDINES
... Take a mixture of 4-[(p-methylbenzyl)oxy]-3-methoxy benzaldehyde (1) (0.01M) and 4- methoxy aceto phenone (0.01) in methanol, add a NaOH (0.002M) to the reaction mixture. The reaction mixture was ...
7